src/hg/makeDb/trackDb/cpgIslandExt.html 1.17
1.17 2009/04/17 19:22:43 kuhn
slightly edited text
Index: src/hg/makeDb/trackDb/cpgIslandExt.html
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RCS file: /projects/compbio/cvsroot/kent/src/hg/makeDb/trackDb/cpgIslandExt.html,v
retrieving revision 1.16
retrieving revision 1.17
diff -b -B -U 4 -r1.16 -r1.17
--- src/hg/makeDb/trackDb/cpgIslandExt.html 31 Mar 2008 18:23:59 -0000 1.16
+++ src/hg/makeDb/trackDb/cpgIslandExt.html 17 Apr 2009 19:22:43 -0000 1.17
@@ -7,13 +7,13 @@
G (guanine) base (a CpG) is rare in
vertebrate DNA because the Cs in such an arrangement tend to be
methylated. This methylation helps distinguish the newly synthesized
DNA strand from the parent strand, which aids in the final stages of
-DNA proofreading after duplication. However, over evolutionary time
+DNA proofreading after duplication. However, over evolutionary time,
methylated Cs tend to turn into Ts because of spontaneous
deamination. The result is that CpGs are relatively rare unless
there is selective pressure to keep them or a region is not methylated
-for some reason, perhaps having to do with the regulation of gene
+for some other reason, perhaps having to do with the regulation of gene
expression. CpG islands are regions where CpGs are present at
significantly higher levels than is typical for the genome as a whole.
</P>