src/hg/makeDb/trackDb/netPanTro2.html 1.3
1.3 2009/06/19 18:40:15 kuhn
tweaked pubMed format per ann
Index: src/hg/makeDb/trackDb/netPanTro2.html
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RCS file: /projects/compbio/cvsroot/kent/src/hg/makeDb/trackDb/netPanTro2.html,v
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retrieving revision 1.3
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<H2>Description</H2>
<P>
This track shows the best $o_organism/$organism chain for
every part of the $organism genome. It is useful for
finding orthologous regions and for studying genome
rearrangement. The $o_organism sequence used in this annotation is from
the $o_date ($o_db) assembly.</P>
<H2>Display Conventions and Configuration</H2>
<P>
In full display mode, the top-level (level 1)
chains are the largest, highest-scoring chains that
span this region. In many cases gaps exist in the
top-level chain. When possible, these are filled in by
other chains that are displayed at level 2. The gaps in
level 2 chains may be filled by level 3 chains and so
forth. </P>
<P>
In the graphical display, the boxes represent ungapped
alignments; the lines represent gaps. Click
on a box to view detailed information about the chain
as a whole; click on a line to display information
about the gap. The detailed information is useful in determining
the cause of the gap or, for lower level chains, the genomic
rearrangement. </P>
<P>
Individual items in the display are categorized as one of four types
(other than gap):</P>
<P><UL>
<LI><B>Top</B> - the best, longest match. Displayed on level 1.
<LI><B>Syn</B> - line-ups on the same chromosome as the gap in the level above
it.
<LI><B>Inv</B> - a line-up on the same chromosome as the gap above it, but in
the opposite orientation.
<LI><B>NonSyn</B> - a match to a chromosome different from the gap in the
level above.
</UL></P>
<H2>Methods</H2>
<P>
Chains were derived from blastz alignments, using the methods
described on the chain tracks description pages, and sorted with the
highest-scoring chains in the genome ranked first. The program
chainNet was then used to place the chains one at a time, trimming them as
necessary to fit into sections not already covered by a higher-scoring chain.
During this process, a natural hierarchy emerged in which a chain that filled
a gap in a higher-scoring chain was placed underneath that chain. The program
netSyntenic was used to fill in information about the relationship between
higher- and lower-level chains, such as whether a lower-level
chain was syntenic or inverted relative to the higher-level chain.
The program netClass was then used to fill in how much of the gaps and chains
contained <em>N</em>s (sequencing gaps) in one or both species and how much
was filled with transposons inserted before and after the two organisms
diverged.</P>
<H2>Credits</H2>
<P>
The chainNet, netSyntenic, and netClass programs were
developed at the University of California
Santa Cruz by Jim Kent.</P>
<P>
Blastz was developed at <A HREF="http://bio.cse.psu.edu"
TARGET=_blank>Pennsylvania State University</A> by
Minmei Hou, Scott Schwartz, Zheng Zhang, and Webb Miller with advice from
Ross Hardison.</P>
<P>
Lineage-specific repeats were identified by Arian Smit and his program
<A HREF="http://www.repeatmasker.org" TARGET=_blank>RepeatMasker</A>.</P>
<P>
The browser display and database storage of the nets were made
by Robert Baertsch and Jim Kent.</P>
<H2>References</H2>
<P>
-Kent WJ, Baertsch R, Hinrichs A, Miller W, and Haussler D.
+Kent WJ, Baertsch R, Hinrichs A, Miller W, Haussler D.
<A HREF="http://www.pnas.org/cgi/content/abstract/1932072100v1"
TARGET=_blank>Evolution's cauldron: Duplication, deletion, and rearrangement
in the mouse and human genomes</A>.
-<EM>Proc Natl Acad Sci USA</EM>, 2003, 100(20):11484-9.</P>
+<EM>Proc Natl Acad Sci USA</EM>. 2003;100(20):11484-9.</P>
<P>
Schwartz S, Kent WJ, Smit A, Zhang Z, Baertsch R, Hardison R,
-Haussler D, and Miller W.
+Haussler D, Miller W.
<A HREF="http://www.genome.org/cgi/content/abstract/13/1/103"
TARGET=_blank>Human-Mouse Alignments with BLASTZ</A>.
-<EM>Genome Res.</EM>, 2003, 13(1):103-7.</P>
+<EM>Genome Res</EM>. 2003;13(1):103-7.</P>