d5ecbacc5d4fc279e837d0ec7176a4a95fbfd2a6
kent
  Tue Aug 28 16:33:00 2012 -0700
Reworking command line and refactoring to add monomer classification info.  Not yet implemented, just refactoring.
diff --git src/kehayden/alphaChain/alphaChain.c src/kehayden/alphaChain/alphaChain.c
index 583707f..af954a7 100644
--- src/kehayden/alphaChain/alphaChain.c
+++ src/kehayden/alphaChain/alphaChain.c
@@ -7,54 +7,76 @@
 #include "dystring.h"
 #include "dlist.h"
 
 /* Global vars - all of which can be set by command line options. */
 int maxChainSize = 3;
 int outSize = 10000;
 boolean fullOnly = FALSE;
 
 void usage()
 /* Explain usage and exit. */
 {
 errAbort(
   "alphaChain - create a linear projection of alpha satellite arrays using the probablistic model\n"
   "of HuRef satellite graphs\n"
   "usage:\n"
-  "   alphaChain alphaMonFile.fa significant_output.txt\n"
+  "   alphaChain alphaMonFile.fa monomerOrder.txt significant_output.txt\n"
   "options:\n"
   "   -size=N - Set max chain size, default %d\n"
   "   -fullOnly - Only output chains of size above\n"
   "   -chain=fileName - Write out word chain to file\n"
   "   -afterChain=fileName - Write out word chain after faux generation to file for debugging\n"
   "   -outSize=N - Output this many words.\n"
   "   -seed=N - Initialize random number with this seed for consistent results, otherwise\n"
   "             it will generate different results each time it's run.\n"
   , maxChainSize
   );
 }
 
 /* Command line validation table. */
 static struct optionSpec options[] = {
    {"size", OPTION_INT},
    {"chain", OPTION_STRING},
    {"afterChain", OPTION_STRING},
    {"fullOnly", OPTION_BOOLEAN},
    {"outSize", OPTION_INT},
    {"seed", OPTION_INT},
    {NULL, 0},
 };
 
+/* Some structures to keep track of words (which correspond to alpha satellight monomers)
+ * seen in input. */
+
+struct wordInfo
+/* Basic information on a word including how many times it is seen in input and output
+ * streams.  Unlike the wordTree, this is flat, and does not include predecessors. */
+    {
+    struct wordInfo *next;	/* Next in list of all words. */
+    char *word;			/* The word itself.  Not allocated here. */
+    int useCount;		/* Number of times used. */
+    int outTarget;		/* Number of times want to output word. */
+    int outCount;		/* Number of times have output word so far. */
+    };
+
+struct wordStore
+/* Stores info on all words */
+    {
+    struct wordInfo *list;   /* List of words, fairly arbitrary order. */
+    struct hash *hash;	     /* Hash of wordInfo, keyed by word. */
+    struct wordTree *markovChains;   /* Tree of words that follow other words. */
+    };
+
 /* The wordTree structure below is the central data structure for this program.  It is
  * used to build up a tree that contains all observed N-word-long sequences observed in
  * the text, where N corresponds to the "size" command line option which defaults to 3,
  * an option that in turn is stored in the maxChainSize variable.  At this chain size the
  * text 
  *     this is the black dog and the black cat
  * would have the chains 
  *     this is the 
  *     is the black
  *     the black dog
  *     black dog and
  *     dog and the
  *     and the black
  *     the black cat
  * and turn into the tree
@@ -79,72 +101,72 @@
  *           black
  * Note how the tree is able to compress the two chains "the black dog" and "the black cat."
  *
  * A node in the tree can have as many children as it needs to at each node.  The depth of
  * the tree is the same as the chain size, by default 3. At each node in the tree you get
  * a word, and a list of all words that are observed in the text to follow that word.
  *
  * Once the program has build up the wordTree, it can output it in a couple of fashions. */
 
 struct wordTree
 /* A node in a tree of words.  The head of the tree is a node with word value the empty string. */
     {
     struct wordTree *next;	/* Next sibling */
     struct wordTree *children;	/* Children in list. */
     struct wordTree *parent;    /* Parent of this node or NULL for root. */
-    char *word;			/* The word itself including comma, period etc. */
-    int useCount;		/* Number of times word used in input. */
-    int outTarget;              /* Number of times want to output word. */
-    int outCount;		/* Number of times output. */
+    struct wordInfo *info;	/* The info on the word itself. */
+    int useCount;		/* Number of times word used in input with given predecessors. */
+    int outTarget;              /* Number of times want to output word with given predecessors. */
+    int outCount;		/* Number of times actually output with given predecessors. */
     double normVal;             /* value to place the normalization value */    
     };
 
-struct wordTree *wordTreeNew(char *word)
+struct wordTree *wordTreeNew(struct wordInfo *info)
 /* Create and return new wordTree element. */
 {
 struct wordTree *wt;
 AllocVar(wt);
-wt->word = cloneString(word);
+wt->info = info;
 return wt;
 }
 
 int wordTreeCmpWord(const void *va, const void *vb)
 /* Compare two wordTree for slSort. */
 {
 const struct wordTree *a = *((struct wordTree **)va);
 const struct wordTree *b = *((struct wordTree **)vb);
-return cmpStringsWithEmbeddedNumbers(a->word, b->word);
+return cmpStringsWithEmbeddedNumbers(a->info->word, b->info->word);
 }
 
-struct wordTree *wordTreeFindInList(struct wordTree *list, char *word)
+struct wordTree *wordTreeFindInList(struct wordTree *list, struct wordInfo *info)
 /* Return wordTree element in list that has given word, or NULL if none. */
 {
 struct wordTree *wt;
 for (wt = list; wt != NULL; wt = wt->next)
-    if (sameString(wt->word, word))
+    if (wt->info == info)
         break;
 return wt;
 }
 
-struct wordTree *wordTreeAddFollowing(struct wordTree *wt, char *word)
+struct wordTree *wordTreeAddFollowing(struct wordTree *wt, struct wordInfo *info)
 /* Make word follow wt in tree.  If word already exists among followers
  * return it and bump use count.  Otherwise create new one. */
 {
-struct wordTree *child = wordTreeFindInList(wt->children, word);
+struct wordTree *child = wordTreeFindInList(wt->children, info);
 if (child == NULL)
     {
-    child = wordTreeNew(word);
+    child = wordTreeNew(info);
     child->parent = wt;
     slAddHead(&wt->children, child);
     }
 child->useCount += 1;
 return child;
 }
 
 int wordTreeSumUseCounts(struct wordTree *list)
 /* Sum up useCounts in list */
 {
 int total = 0;
 struct wordTree *wt;
 for (wt = list; wt != NULL; wt = wt->next)
     total += wt->useCount;
 return total;
@@ -155,99 +177,100 @@
 {
 int total = 0;
 struct wordTree *wt;
 for (wt = list; wt != NULL; wt = wt->next)
     total += wt->outTarget;
 return total;
 }
 
 void addChainToTree(struct wordTree *wt, struct dlList *chain)
 /* Add chain of words to tree. */
 {
 struct dlNode *node;
 wt->useCount += 1;
 for (node = chain->head; !dlEnd(node); node = node->next)
     {
-    char *word = node->val;
-    verbose(2, "  adding %s\n", word);
-    wt = wordTreeAddFollowing(wt, word);
+    struct wordInfo *info = node->val;
+    verbose(2, "  adding %s\n", info->word);
+    wt = wordTreeAddFollowing(wt, info);
     }
 }
 
 void wordTreeNormalize(struct wordTree *wt, double outTarget, double normVal)
 /* Recursively set wt->normVal  and wt->outTarget so each branch gets its share */
 {
 wt->normVal = normVal;
 wt->outTarget = outTarget;
 int childrenTotalUses = wordTreeSumUseCounts(wt->children);
 struct wordTree *child;
 for (child = wt->children; child != NULL; child = child->next)
     {
     double childRatio = (double)child->useCount / childrenTotalUses;
     wordTreeNormalize(child, childRatio*outTarget, childRatio*normVal);
     }
 }
 
 char *wordTreeString(struct wordTree *wt)
 /* Return something like '(a b c)' where c would be the value at wt itself, and
  * a and b would be gotten by following parents. */
 {
 struct slName *list = NULL, *el;
 for (;wt != NULL; wt = wt->parent)
     {
-    if (!isEmpty(wt->word))   // Avoid blank great grandparent
-	slNameAddHead(&list, wt->word);
+    char *word = wt->info->word;
+    if (!isEmpty(word))   // Avoid blank great grandparent
+	slNameAddHead(&list, word);
     }
 
 struct dyString *dy = dyStringNew(0);
 dyStringAppendC(dy, '(');
 for (el = list; el != NULL; el = el->next)
    {
    dyStringPrintf(dy, "%s", el->name);
    if (el->next != NULL)
        dyStringAppendC(dy, ' ');
    }
 dyStringAppendC(dy, ')');
 slFreeList(&list);
 return dyStringCannibalize(&dy);
 }
 
 char *dlListFragWords(struct dlNode *head)
 /* Return string containing all words in list pointed to by head. */
 {
 struct dyString *dy = dyStringNew(0);
 dyStringAppendC(dy, '{');
 struct dlNode *node;
 for (node = head; !dlEnd(node); node = node->next)
     {
     if (node != head)
        dyStringAppendC(dy, ' ');
-    char *word = node->val;
-    dyStringAppend(dy, word);
+    struct wordInfo *info = node->val;
+    dyStringAppend(dy, info->word);
     }
 dyStringAppendC(dy, '}');
 return dyStringCannibalize(&dy);
 }
 
 void wordTreeDump(int level, struct wordTree *wt, FILE *f)
 /* Write out wordTree to file. */
 {
 static char *words[64];
 int i;
 assert(level < ArraySize(words));
 
-words[level] = wt->word;
+words[level] = wt->info->word;
 if (!fullOnly || level == maxChainSize)
     {
     fprintf(f, "%d\t%d\t%d\t%d\t%f\t", 
 	    level, wt->useCount, wt->outTarget, wt->outCount, wt->normVal);
     
     for (i=1; i<=level; ++i)
 	{
 	spaceOut(f, level*2);
 	fprintf(f, "%s ", words[i]);
 	}
     fprintf(f, "\n");
     }
 struct wordTree *child;
 for (child = wt->children; child != NULL; child = child->next)
     wordTreeDump(level+1, child, f);
@@ -255,54 +278,54 @@
 
 struct wordTree *pickRandomOnOutTarget(struct wordTree *list)
 /* Pick word from list randomly, but so that words with higher outTargets
  * are picked more often. */
 {
 struct wordTree *picked = NULL;
 
 /* Debug output. */
     {
     verbose(2, "   pickRandomOnOutTarget(");
     struct wordTree *wt;
     for (wt = list; wt != NULL; wt = wt->next)
         {
 	if (wt != list)
 	    verbose(2, " ");
-	verbose(2, "%s:%d", wt->word, wt->outTarget);
+	verbose(2, "%s:%d", wt->info->word, wt->outTarget);
 	}
     verbose(2, ") total %d\n", wordTreeSumOutTargets(list));
     }
 
 /* Figure out total number of outputs left, and a random number between 0 and that total. */
 int total = wordTreeSumOutTargets(list);
 if (total > 0)
     {
     int threshold = rand() % total; 
     verbose(2, "      threshold %d\n", threshold);
 
     /* Loop through list returning selection corresponding to random threshold. */
     int binStart = 0;
     struct wordTree *wt;
     for (wt = list; wt != NULL; wt = wt->next)
 	{
 	int size = wt->outTarget;
 	int binEnd = binStart + size;
-	verbose(2, "      %s size %d, binEnd %d\n", wt->word, size, binEnd);
+	verbose(2, "      %s size %d, binEnd %d\n", wt->info->word, size, binEnd);
 	if (threshold < binEnd)
 	    {
 	    picked = wt;
-	    verbose(2, "      picked %s\n", wt->word);
+	    verbose(2, "      picked %s\n", wt->info->word);
 	    break;
 	    }
 	binStart = binEnd;
 	}
     }
 return picked;
 }
 
 struct wordTree *pickRandomOnUseCounts(struct wordTree *list)
 /* Pick word from list randomly, but so that words with higher useCounts
  * are picked more often.  Much like above routine, but a little simple
  * since we know useCounts are non-zero. */
 {
 struct wordTree *picked = NULL;
 
@@ -345,86 +368,87 @@
     picked = pickRandomOnUseCounts(list);
     ++totUseZeroCount;
     }
 return picked;
 }
 
 struct wordTree *predictNextFromAllPredecessors(struct wordTree *wt, struct dlNode *list)
 /* Predict next word given tree and recently used word list.  If tree doesn't
  * have statistics for what comes next given the words in list, then it returns
  * NULL. */
 {
 verbose(2, " predictNextFromAllPredecessors(%s, %s)\n", wordTreeString(wt), dlListFragWords(list));
 struct dlNode *node;
 for (node = list; !dlEnd(node); node = node->next)
     {
-    char *word = node->val;
-    wt = wordTreeFindInList(wt->children, word);
-    verbose(2, "   wordTreeFindInList(%s) = %p %s\n", word, wt, wordTreeString(wt));
+    struct wordInfo *info = node->val;
+    wt = wordTreeFindInList(wt->children, info);
+    verbose(2, "   wordTreeFindInList(%s) = %p %s\n", info->word, wt, wordTreeString(wt));
     if (wt == NULL || wt->children == NULL)
         break;
     }
 struct wordTree *result = NULL;
 if (wt != NULL && wt->children != NULL)
     result = pickRandom(wt->children);
 return result;
 }
 
 struct wordTree *predictNext(struct wordTree *wt, struct dlList *recent)
 /* Predict next word given tree and recently used word list.  Will use all words in
  * recent list if can,  but if there is not data in tree, will back off, and use
  * progressively less previous words until ultimately it just picks a random
  * word. */
 {
 struct dlNode *node;
 
 for (node = recent->head; !dlEnd(node); node = node->next)
     {
     struct wordTree *result = predictNextFromAllPredecessors(wt, node);
     if (result != NULL)
         return result;
     }
 struct wordTree *topLevel = pickRandom(wt->children);
 verbose(2, "in predictNext(%s, %s) ", wordTreeString(wt), dlListFragWords(recent->head));
-verbose(2, "last resort pick of %s\n", topLevel->word);
+verbose(2, "last resort pick of %s\n", topLevel->info->word);
 return topLevel;
 }
 
 void decrementOutputCounts(struct wordTree *wt)
 /* Decrement output count of self and parents. */
 {
 while (wt != NULL)
     {
     /* Decrement target count, but don't let it fall below sum of counts of all children. 
      * This can happen with incomplete data if we don't prevent it.  This
      * same code also prevents us from having negative outTarget. */
     int outTarget = wt->outTarget - 1;
     int kidSum = wordTreeSumOutTargets(wt->children);
     if (outTarget < kidSum)
         outTarget = kidSum;
     wt->outTarget = outTarget;
 
     /* Always bump outCount for debugging. */
     wt->outCount += 1;
     wt = wt->parent;
     }
 }
 
-static void wordTreeGenerateFaux(struct wordTree *wt, int maxSize, struct wordTree *firstWord, 
+static void wordTreeGenerateFaux(struct wordStore *store, int maxSize, struct wordTree *firstWord, 
 	int maxOutputWords, char *fileName)
 /* Go spew out a bunch of words according to probabilities in tree. */
 {
+struct wordTree *wt = store->markovChains;
 FILE *f = mustOpen(fileName, "w");
 struct dlList *ll = dlListNew();
 int listSize = 0;
 int outputWords = 0;
 
 for (;;)
     {
     if (++outputWords > maxOutputWords)
         break;
     struct dlNode *node;
     struct wordTree *picked;
 
     /* Get next predicted word. */
     if (listSize == 0)
         {
@@ -437,152 +461,176 @@
 	node = dlPopHead(ll);
 	picked = predictNext(wt, ll);
 	}
     else
 	{
 	picked = predictNext(wt, ll);
 	AllocVar(node);
 	++listSize;
 	}
 
     if (picked == NULL)
          break;
 
 
     /* Add word from whatever level we fetched back to our chain of up to maxChainSize. */
-    node->val = picked->word;
+    node->val = picked->info;
     dlAddTail(ll, node);
 
-    fprintf(f, "%s\n", picked->word);
+    fprintf(f, "%s\n", picked->info->word);
 
     decrementOutputCounts(picked);
     }
 dlListFree(&ll);
 carefulClose(&f);
 verbose(2, "totUseZeroCount = %d\n", totUseZeroCount);
 }
 
 static void wordTreeSort(struct wordTree *wt)
 /* Sort all children lists in tree. */
 {
 slSort(&wt->children, wordTreeCmpWord);
 struct wordTree *child;
 for (child = wt->children; child != NULL; child = child->next)
     wordTreeSort(child);
 }
 
-struct wordTree *wordTreeForChainsInFile(char *fileName, int chainSize)
-/* Return a wordTree of all chains-of-words of length chainSize seen in file. 
- * Allocate the structure in local memory pool lm. */ 
+struct wordStore *wordStoreNew()
+/* Allocate and initialize a new word store. */
+{
+struct wordStore *store;
+AllocVar(store);
+store->hash = hashNew(0);
+return store;
+}
+
+struct wordInfo *wordStoreAdd(struct wordStore *store, char *word)
+/* Add word to store,  incrementing it's useCount if it's already there, otherwise
+ * making up a new record for it. */
+{
+struct wordInfo *info = hashFindVal(store->hash, word);
+if (info == NULL)
+    {
+    AllocVar(info);
+    hashAddSaveName(store->hash, word, info, &info->word);
+    }
+info->useCount += 1;
+return info;
+}
+
+struct wordStore *wordStoreForChainsInFile(char *fileName, int chainSize)
+/* Return a wordStore containing all words, and also all chains-of-words of length 
+ * chainSize seen in file.  */
 {
 /* Stuff for processing file a line at a time. */
 struct lineFile *lf = lineFileOpen(fileName, TRUE);
 char *line, *word;
 
 /* We'll build up the tree starting with an empty root node. */
-struct wordTree *wt = wordTreeNew("");	
+struct wordStore *store = wordStoreNew();
+struct wordTree *wt = store->markovChains = wordTreeNew(wordStoreAdd(store, ""));	
 
 /* Loop through each line of file, treating it as a separate read. There's 
  * special cases at the beginning and end of line, and for short lines.  In the
  * main case we'll be maintaining a chain (doubly linked list) of maxChainSize words, 
  * popping off one word from the start, and adding one word to the end for each
  * new word we encounter. This list is added to the tree each iteration. */
 while (lineFileNext(lf, &line, NULL))
     {
     /* We'll keep a chain of three or so words in a doubly linked list. */
     struct dlNode *node;
     struct dlList *chain = dlListNew();
     int curSize = 0;
     int wordCount = 0;
 
     /* skipping the first word which is the read id */
     word = nextWord(&line);
 
     while ((word = nextWord(&line)) != NULL)
 	{
+	struct wordInfo *info = wordStoreAdd(store, word);
 	 /* For the first few words in the file after ID, we'll just build up the chain,
 	 * only adding it to the tree when we finally do get to the desired
 	 * chain size.  Once past the initial section of the file we'll be
 	 * getting rid of the first link in the chain as well as adding a new
 	 * last link in the chain with each new word we see. */
 	if (curSize < chainSize)
 	    {
-	    dlAddValTail(chain, cloneString(word));
+	    dlAddValTail(chain, info);
 	    ++curSize;
 	    if (curSize == chainSize)
 		addChainToTree(wt, chain);
 	    }
 	else
 	    {
 	    /* Reuse doubly-linked-list node, but give it a new value, as we move
 	     * it from head to tail of list. */
 	    node = dlPopHead(chain);
-	    freeMem(node->val);
-	    node->val = cloneString(word);
+	    node->val = info;
 	    dlAddTail(chain, node);
 	    addChainToTree(wt, chain);
 	    }
 	++wordCount;
 	}
     /* Handle last few words in line, where can't make a chain of full size.  Also handles       
     * lines that have fewer than chain size words. */
     if (curSize < chainSize)
  	addChainToTree(wt, chain);
     while ((node = dlPopHead(chain)) != NULL)
 	{
 	if (!dlEmpty(chain))
 	    addChainToTree(wt, chain);
-	freeMem(node->val);
 	freeMem(node);
 	}
     dlListFree(&chain);
     }
 lineFileClose(&lf);
 
 wordTreeSort(wt);  // Make output of chain file prettier
-return wt;
+return store;
 }
 
 void wordTreeWrite(struct wordTree *wt, char *fileName)
 /* Write out tree to file */
 {
 FILE *f = mustOpen(fileName, "w");
 fprintf(f, "#level\tuseCount\toutTarget\toutCount\tnormVal\tmonomers\n");
 wordTreeDump(0, wt, f);
 carefulClose(&f);
 }
 
-void alphaChain(char *inFile, char *outFile)
+void alphaChain(char *readsFile, char *monomerOrderFile, char *outFile)
 /* alphaChain - Create Markov chain of words and optionally output chain in two formats. */
 {
-struct wordTree *wt = wordTreeForChainsInFile(inFile, maxChainSize);
+struct wordStore *store = wordStoreForChainsInFile(readsFile, maxChainSize);
+struct wordTree *wt = store->markovChains;
 wordTreeNormalize(wt, outSize, 1.0);
 
 if (optionExists("chain"))
     {
     char *fileName = optionVal("chain", NULL);
     wordTreeWrite(wt, fileName);
     }
 
-wordTreeGenerateFaux(wt, maxChainSize, pickRandom(wt->children), outSize, outFile);
+wordTreeGenerateFaux(store, maxChainSize, pickRandom(wt->children), outSize, outFile);
 
 if (optionExists("afterChain"))
     {
     char *fileName = optionVal("afterChain", NULL);
     wordTreeWrite(wt, fileName);
     }
 }
 
 int main(int argc, char *argv[])
 /* Process command line. */
 {
 optionInit(&argc, argv, options);
-if (argc != 3)
+if (argc != 4)
     usage();
 maxChainSize = optionInt("size", maxChainSize);
 outSize = optionInt("outSize", outSize);
 fullOnly = optionExists("fullOnly");
 int seed = optionInt("seed", (int)time(0));
 srand(seed);
-alphaChain(argv[1], argv[2]);
+alphaChain(argv[1], argv[2], argv[3]);
 return 0;
 }