976e5f5a2582e99913f82839e86efccdca88d814 angie Fri Mar 22 13:12:51 2013 -0700 Adding information from the Database of Non-Synonymous Functional Prediction(dbNSFP, https://sites.google.com/site/jpopgen/dbNSFP, http://dbnsfp.houstonbioinformatics.org/dbNSFPzip/dbNSFP2.0.readme.txt). dbNSFP2.0 contains precomputed predictions from a variety of tools of the effects of all possible missense variants on protein-coding Gencode rel 9 (Ens 64) transcripts. For example, it contains scores and predictions from SIFT, PolyPhen2 and similar tools (MutationTaster, MutationAssessor, LRT), as well as GERP scores at CDS positions and associated domain information from InterPro and IDs from UniProt. Each subset is extracted into a bigBed or bigWig file so that users of the Variant Annotation Integrator will be able to apply one or more of these prediction methods to their variants. refs #6152 diff --git src/hg/utils/makefile src/hg/utils/makefile index c2c9218..ebe48ce 100644 --- src/hg/utils/makefile +++ src/hg/utils/makefile @@ -1,76 +1,78 @@ # Build all directories in utils # test comment # $Id: makefile,v 1.21 2010/06/04 00:12:42 larrym Exp $ include ../../inc/common.mk SCRIPT_FILES = \ + dbNsfpToBed.pl \ dumpDb.pl \ - mergeOverlapBed4.pl + mergeOverlapBed4.pl \ + mergeSortedBed3Plus.pl # List of directories to build USE_DIRS = $(DIRS) DIRS = \ bedToPsl \ bedExtendRanges \ bedWeedOverlapping \ chromGraphFromBin \ chromGraphToBin \ crTreeIndexBed \ crTreeSearchBed \ gapToLift \ hubCheck hubPublicCheck \ makeTableList \ oligoMatch \ positionalTblCheck \ safePush \ toDev64 \ twoBitMask \ gff3ToGenePred \ gff3ToPsl \ gtfToGenePred \ automation \ refreshNamedSessionCustomTracks \ refSeqGet \ tdbQuery \ wigBedToStep \ overlapSelect \ pslMap \ pslUniq \ makeTrackIndex \ geoMirrorNode TEST_DIRS = \ gff3ToGenePred \ gff3ToPsl \ gtfToGenePred \ overlapSelect \ pslMap \ refSeqGet all:: utils utils: $(USE_DIRS:%=%.utils) %.utils: (cd $* && $(MAKE)) scripts: $(SCRIPT_FILES:%=%.scripts) %.scripts: chmod +x $* rm -f ${SCRIPTS}/$* cp -p $* ${SCRIPTS}/$* alpha: scripts all test:: ${TEST_DIRS:%=%.test} %.test: (cd $* && ${MAKE} test) clean:: $(USE_DIRS:%=%.clean) - find . -name '*.o' -exec rm {} \; %.clean: (cd $* && ${MAKE} clean)