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steve
  Fri Apr 11 14:27:53 2014 -0700
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                  <font size="4"><a name="TOC"></a><b>&nbsp; News</b></font><a href="http://www.twitter.com/GenomeBrowser" target="_blank"><img src="http://twitter-badges.s3.amazonaws.com/t_small-a.png" alt="Follow GenomeBrowser on Twitter" style="vertical-align:text-bottom; margin-left: 15px;"></a></TD>
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           <P>
           To receive announcements of new genome 
           assembly releases, new software features, updates and 
           training seminars by email, subscribe to the
           <A HREF="http://groups.google.com/a/soe.ucsc.edu/group/genome-announce?hl=en"
           TARGET=_blank>genome-announce</A> mailing list.</P>
 
     <!-- start news -->
 
         <hr>
         <p>
         <font face="courier" size="3"><b>11 April 2014 -
         New UCSC Genes Track Released for GRCm38/mm10</b></font>
         <p>
         We're happy to announce the release of an updated UCSC Genes track for the GRCm38/mm10
         mouse Genome Browser.  The new release has 61,642 total transcripts, compared with 59,121
         in the previous version.  The total number of canonical genes has increased from 31,469
         to 32,408.  Comparing the new gene set with the previous version:
         <ul>
           <li>54,714 transcripts did not change between versions.</li>
           <li>19 transcripts were not carried forward to the new version.</li>
           <li>3,866 transcripts are &quot;compatible&quot; with those in the previous set, meaning
               that the two transcripts show consistent splicing.  In most cases, the old and new
               transcripts differ in the lengths of their UTRs.</li>
           <li>522 transcripts overlap with those in the previous set, but do not show consistent
               splicing (i.e., they contain overlapping introns with differing splice sites).</li>
         </ul>
         </p>
         <p>
         More details about the new UCSC Genes track can be found on the
         <a href="../cgi-bin/hgTrackUi?db=mm10&g=knownGene">UCSC Genes track
         description page</a>.
         </p>
 
         <p>
         Many thanks to Brian Raney and Steve Heitner for their work on this track!
         </p>
         
 	<hr>
 	<p>
         <font face="courier" size="3"><b>06 March 2014 - 
 	The new GRCh38 Human Genome Browser is here!</b></font>
 	<p>
 	In the final days of 2013, the 
 	<a href="http://www.ncbi.nlm.nih.gov/projects/genome/assembly/grc/" 
 	target="_blank">Genome Reference Consortium</a> (GRC) released the eagerly awaited GRCh38 
 	human genome assembly, the first major revision of the human genome in more than four 
 	years. During the past two months, the UCSC team has been 
 	hard at work building a browser that will let our users explore the new
 	assembly using their favorite Genome Browser features and tools. 
 	Today we're announcing the release of a preliminary browser on the GRCh38
 	assembly. Although we still have plenty of work ahead of us in constructing the rich
 	feature set that our users have come to expect, this early release will allow you to
 	take a peek at what's new. 
 	<p>
 	Starting with this release, the UCSC Genome Browser version numbers for human 
 	assemblies will match those of the GRC to minimize version confusion. Hence, the GRCh38 
 	assembly is referred to as hg38 in Genome Browser datasets and documentation. We've
 	also made some slight changes to our chromosome naming scheme that affect primarily the 
 	names of haplotype chromosomes, unplaced contigs and unlocalized contigs. For more details 
 	about this, see the 
 	<a href="../cgi-bin/hgGateway?db=hg38">hg38 gateway page</a>.  
 	<p>
 	<b>What's new in GRCh38?</b> 
 	<ul>
 	<li>
 	<b>Alternate sequences</b> - Several human chromosomal regions exhibit sufficient 
 	variability to prevent adequate representation by a single sequence. To address this, the 
 	GRCh38 assembly provides alternate sequence for selected variant regions through the 
 	inclusion of  <em>alternate loci scaffolds</em> (or <em>alt loci</em>). Alt loci are 
 	separate accessioned sequences that are aligned to reference chromosomes. This assembly 
 	contains 261 alt loci, many of which are associated with the LRC/KIR area of chr19 and the 
 	MHC region on chr6. (See the 
 	<a href="../cgi-bin/hgTracks?chromInfoPage=">sequences</a> page for a complete list of the 
 	reference chromosomes and alternate sequences in GRCh38.)
 	<li>
 	<b>Centromere representation</b> - Debuting in this release, the large megabase-sized gaps 
 	that were previously used to represent centromeric regions in human assemblies have been 
 	replaced by sequences from centromere models created by 
 	<a href="http://genome.cshlp.org/content/early/2014/02/05/gr.159624.113.abstract"
 	target="_blank">Karen Miga et al.</a>, using centromere databases developed during her 
 	work in the <a href="http://www.genome.duke.edu/labs/WillardLab/" 
 	target="_blank">Willard lab</a> at 
 	Duke University and analysis software developed while working in the 
 	<a href="http://cbse.soe.ucsc.edu/people/kent" target="_blank">Kent lab</a> at UCSC.
 	The models, which provide the 
 	approximate repeat number and order for each centromere, will be useful for read mapping 
 	and variation studies. 
 	<li>
 	<b>Mitochondrial genome</b> - The mitochondrial reference sequence included in the GRCh38 
 	assembly and hg38 Genome Browser (termed &quot;chrM&quot; in the browser) is the 
 	<a href="http://mitomap.org/bin/view.pl/MITOMAP/HumanMitoSeq" 
 	target="_blank">Revised Cambridge Reference Sequence</a> (rCRS) from 
 	<a href="http://mitomap.org/MITOMAP" target="_blank">MITOMAP</a> with GenBank accession 
 	number J01415.2 and RefSeq accession number NC_012920.1. This differs from the chrM 
 	sequence (RefSeq accession number NC_001907) used by the previous hg19 Genome Browser, 
 	which was not updated when the GRCh37 assembly later transitioned to the new version.
 	<li>
 	<b>Sequence updates</b> - Several erroneous bases and misassembled regions in GRCh37 have 
 	been corrected in the GRCh38 assembly, and more than 100 gaps have been filled or reduced. 
 	Much of the data used to improve the reference sequence was obtained from other genome 
 	sequencing and analysis projects, such as the <a href="http://www.1000genomes.org/" 
 	target="_blank">1000 Genomes Project</a>.  
 	<li>
 	<b>Analysis set</b> - The GRCh38 assembly offers an &quot;analysis set&quot; that was 
 	created to accommodate next generation sequencing read alignment pipelines. Several
 	GRCh38 regions have been eliminated from this set to improve read mapping. 
 	The analysis set may be downloaded from the Genome Browser 
 	<a href="http://hgdownload.cse.ucsc.edu/goldenPath/hg38/bigZips/analysisSet/"
 	target="_blank">downloads page</a>.
 	</ul>
 	<p>
 	For more information about the files included in the GRCh38 GenBank submission, 
 	see the
 	<a href="ftp://ftp.ncbi.nih.gov/genbank/genomes/Eukaryotes/vertebrates_mammals/Homo_sapiens/GRCh38/README"
 	target="_blank">GRCh38 README</a>. The GRCh38 GenBank record provides a detailed
 	array of <a href="http://www.ncbi.nlm.nih.gov/assembly/883148/#/st_Primary-Assembly"
 	target="_blank">statistics about this assembly</a>.
         Bulk downloads of the sequence and annotation data may be obtained from the Genome
         Browser <a href="ftp://hgdownload.cse.ucsc.edu/goldenPath/hg38/">FTP server</a>
         or the
         <a href="http://hgdownload.cse.ucsc.edu/downloads.html#human">Downloads</a>
         page.  The annotation tracks for this browser were generated by UCSC and collaborators 
 	worldwide. 
 	</p>
 	<p>
 	<b>Much more to come!</b> This initial release of the hg38 Genome Browser provides a 
 	rudimentary set of annotations.  Many of our annotations rely on data sets from external 
 	contributors (such as our popular SNPs tracks) or require massive computational effort 
 	(our comparative genomics tracks). In the upcoming months/years, we will release many more 
 	annotation tracks as they become available. To stay abreast of new datasets, join our 
         <a href="http://groups.google.com/a/soe.ucsc.edu/group/genome-announce?hl=en"
 	target="_blank">genome-announce</a> mailing list or follow us on
 	<a href="http://www.twitter.com/GenomeBrowser" target="_blank">twitter</a>.
 	</p>
 	We'd like to thank our GRC and NCBI collaborators who worked closely with
 	us in producing the hg38 browser. Their quick responses and helpful feedback were a
 	key factor in expediting this release. The production of the hg38 Genome Browser was
 	a team effort, but in particular we'd like to acknowledge the engineering efforts of Hiram 
 	Clawson and Brian Raney, the QA work done by Steve Heitner, project guidance
 	provided by Ann Zweig, Robert Kuhn, and Jim Kent, and documentation work by Donna
 	Karolchik.
 	See the <a href="goldenPath/credits.html#human_credits">Credits</a> page for a detailed
         list of the organizations and individuals who contributed to this release.
         </p>
 	<p>
 	<hr>
 
         <!-- staged for archive use
 
         <p>
         <font face="courier" size="3"><b>11 April 2014 -
         New UCSC Genes Track Released for GRCm38/mm10</b></font>
         </p>
         We're happy to announce the release of an updated UCSC Genes
         track for the GRCm38/mm10 mouse Genome Browser.
         <a href="goldenPath/newsarch.html#041114">Read more</a>.
         </p>
 
         <p>
         <font face="courier" size="3"><b>06 March 2014 -
         The new GRCh38 Human Genome Browser is here!</b></font>
         </p>
         In the final days of 2013, the Genome Reference Consortium (GRC)
         released the eagerly awaited GRCh38 human genome assembly, the
         first major revision of the human genome in more than four years.
         <a href="goldenPath/newsarch.html#030614">Read more</a>.
         </p>
 
         -->
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         <p>
         <font face="courier" size="3"><b>04 March 2014 - 
-        Introducing Genome Browser highlight feature</b></font>
-        </p>
+        Introducing Genome Browser highlight feature:</b></font>
         We are excited to announce a new highlight feature in the UCSC
         Genome Browser. Using drag-and-select, you can now highlight a
         region or gene of interest.
  	<a href="goldenPath/newsarch.html#030414">Read more</a>.
 	</p>
 
         <font face="courier" size="3"><b>28 February 2014 -
         New!  Expanded onsite workshop program!:</b></font>
         Explore the full power of the UCSC Genome Browser! 
         Thanks to the funding support of NHGRI, we can now offer hands-on Genome Browser 
         training onsite at your institution. 
         <a href="goldenPath/newsarch.html#022814">Read more</a>. 
         </p>
 
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