7c2d98b2096ecfe0c2a45c4a8b81a0fd41788879 kate Wed Jul 5 14:45:11 2017 -0700 Cleanup before merge. refs #15646 diff --git src/hg/hgc/gtexEqtlClusterClick.c src/hg/hgc/gtexEqtlClusterClick.c index dc4b664..6a46cf6 100644 --- src/hg/hgc/gtexEqtlClusterClick.c +++ src/hg/hgc/gtexEqtlClusterClick.c @@ -1,128 +1,127 @@ /* Details page for GTEx eQTL Clusters */ /* Copyright (C) 2017 The Regents of the University of California * See README in this or parent directory for licensing information. */ #include "common.h" #include "hCommon.h" #include "web.h" #include "gtexTissue.h" #include "gtexInfo.h" #include "gtexEqtlCluster.h" #include "hgc.h" static struct gtexEqtlCluster *getGtexEqtl(char *item, char *chrom, int start, int end, char *table) /* Retrieve this item from the track table */ { char *gene = firstWordInLine(cloneString(item)); struct sqlConnection *conn = hAllocConn(database); struct gtexEqtlCluster *eqtls = NULL, *eqtl; char **row; int offset; char where[512]; sqlSafefFrag(where, sizeof(where), "target='%s'", gene); struct sqlResult *sr = hRangeQuery(conn, table, chrom, start, end, where, &offset); while ((row = sqlNextRow(sr)) != NULL) { eqtl = gtexEqtlClusterLoad(row+offset); slAddHead(&eqtls, eqtl); } slReverse(&eqtls); sqlFreeResult(&sr); hFreeConn(&conn); return eqtls; } static char *getGeneDescription(struct sqlConnection *conn, char *geneName) /* Return description from KnownGenes track */ { char query[256]; sqlSafef(query, sizeof query, "SELECT kgXref.description FROM kgXref WHERE geneSymbol='%s'", geneName); return sqlQuickString(conn, query); } void doGtexEqtlDetails(struct trackDb *tdb, char *item) /* Details of GTEx eQTL item */ { char *chrom = cartString(cart, "c"); int start = cartInt(cart, "o"); int end = cartInt(cart, "t"); struct gtexEqtlCluster *eqtl = getGtexEqtl(item, chrom, start, end, tdb->table); genericHeader(tdb, item); char *version = gtexVersion(tdb->table); struct gtexTissue *tissues = gtexGetTissues(version); struct hash *tissueHash = hashNew(0); struct gtexTissue *tis = NULL; for (tis = tissues; tis != NULL; tis = tis->next) hashAdd(tissueHash, tis->name, tis); int i; struct sqlConnection *conn = hAllocConn(database); char *geneName = eqtl->target; char *desc = getGeneDescription(conn, geneName); printf("<b>Gene: </b>"); if (desc == NULL) printf("%s<br>\n", geneName); else { printf("<a target='_blank' href='%s?db=%s&hgg_gene=%s'>%s</a><br>\n", hgGeneName(), database, geneName, geneName); printf("<b>Description:</b> %s\n", desc); } char posLink[1024]; safef(posLink, sizeof posLink,"<a href='%s&db=%s&position=%s%%3A%d-%d'>%s:%d-%d</a>", hgTracksPathAndSettings(), database, eqtl->chrom, eqtl->chromStart+1, eqtl->chromEnd, eqtl->chrom, eqtl->chromStart+1, eqtl->chromEnd); // TODO: Consider adding Ensembl gene ID, GENCODE biotype and class (as in gtexGene track) printf("<br><b>Variant:</b> %s\n", eqtl->name); printf("<br><b>Position:</b> %s\n", posLink); printf("<br><b>Score:</b> %d\n", eqtl->score); #define FLANK 1000 char query[256]; sqlSafef(query, sizeof query, "SELECT MIN(chromStart) from %s WHERE target='%s'", tdb->table, eqtl->target); start = sqlQuickNum(conn, query) - FLANK; sqlSafef(query, sizeof query, "SELECT MAX(chromEnd) from %s WHERE target='%s'", tdb->table, eqtl->target); end = sqlQuickNum(conn, query) + FLANK; safef(posLink, sizeof posLink,"<a href='%s&db=%s&position=%s%%3A%d-%d'>%s:%d-%d</a>", hgTracksPathAndSettings(), database, eqtl->chrom, start+1, end, eqtl->chrom, start+1, end); printf("<br><b>Region containing eQTLs for this gene:</b> %s (%d bp, including +-%dbp flank)\n", posLink, end-start, FLANK); printf("<br><a target='_blank' href='https://www.gtexportal.org/home/bubbleHeatmapPage/%s'>" "View eQTLs for this gene at the GTEx portal<a>\n", geneName); printf("<br><b>Number of tissues with this eQTL:</b> %d\n", eqtl->expCount); hFreeConn(&conn); webNewSection("eQTL cluster details"); printf("<table id='eqtls' cellspacing=1 cellpadding=3>\n"); -//printf("<style>#eqtls th {text-align: left; background-color: #eaca92;}</style>"); printf("<style>#eqtls th {text-align: left; background-color: #F3E0BE;}</style>"); printf("<tr><th> </th><th>Tissue</th><th>Effect </th><th>Probability </th></tr>\n"); for (i=0; i<eqtl->expCount; i++) { double effect= eqtl->expScores[i]; double prob = eqtl->expProbs[i]; struct gtexTissue *tis = (struct gtexTissue *)hashFindVal(tissueHash, eqtl->expNames[i]); unsigned color = tis ? tis->color : 0; // BLACK char *name = tis ? tis->description : "Unknown"; printf("<tr><td bgcolor=#%06X></td><td>%s</td><td>%s%0.2f</td><td>%0.2f</td></tr>\n", color, name, effect < 0 ? "" : "+", effect, prob); } printf("</table>"); webEndSection(); webNewEmptySection(); printTrackHtml(tdb); }