");
fprintf(fh, "");
if (wds->db)
fprintf(fh, "| Database: %s | Table: %s | \n", wds->db, wds->tblName);
if (wds->isFile)
{
if ( (stringIn("trash/ct_",wds->tblName)) ||
(stringIn("trash/hgtct_",wds->tblName)))
fprintf(fh, " custom track | \n" );
else
fprintf(fh, " from file %s | \n", wds->tblName);
}
wigStatsTableHeading(fh, htmlOut);
}
else
{
if (wds->db)
fprintf(fh, "#\t Database: %s, Table: %s\n",
wds->db, wds->tblName);
if (wds->isFile)
fprintf(fh, "#\t from file, Table: %s\n", wds->tblName);
wigStatsTableHeading(fh, htmlOut);
}
} /* void wigStatsHeader() */
/* strictly object methods following ************************/
/* PRIVATE METHODS ************************************************/
static void addConstraint(struct wiggleDataStream *wds, char *left, char *op, char *right)
{
struct dyString *constrain = dyStringNew(256);
if (wds->sqlConstraint)
dyStringPrintf(constrain, "%s AND ", wds->sqlConstraint);
sqlDyStringPrintfFrag(constrain, "%s %-s \"%s\"", left, op, right);
freeMem(wds->sqlConstraint); /* potentially previously existing */
wds->sqlConstraint = cloneString(constrain->string);
dyStringFree(&constrain);
}
/* *row[] is artifically one too big to allow for a potential bin
* column when reading files that may have it.
*/
static boolean nextRow(struct wiggleDataStream *wds, char *row[], int maxRow)
/* read next wig row from sql query or lineFile
* FALSE return on no more data */
{
int numCols;
if (wds->isFile)
{
/* the file may have a bin column, detect automatically and eliminate */
numCols = lineFileChopNextTab(wds->lf, row, maxRow+1);
if (numCols == maxRow+1)
{
int i;
for (i = 1; i < (maxRow+1); ++i)
row[i-1] = row[i];
}
if (numCols < maxRow) return FALSE;
verbose(VERBOSE_PER_VALUE_LEVEL, "#\tnumCols = %d, row[0]: %s, row[1]: %s, row[%d]: %s\n",
numCols, row[0], row[1], maxRow-1, row[maxRow-1]);
}
else
{
int i;
char **sqlRow;
sqlRow = sqlNextRow(wds->sr);
if (sqlRow == NULL)
return FALSE;
/* skip the bin column sqlRow[0] */
for (i=1; i <= maxRow; ++i)
{
row[i-1] = sqlRow[i];
}
}
return TRUE;
}
static void findWibFile(struct wiggleDataStream *wds, char *file)
/* look for file in full pathname given, or in same directory */
{
wds->wibFile = hReplaceGbdb(file);
wds->wibFH = udcFileMayOpen(wds->wibFile, NULL);
if (wds->wibFH == NULL)
{
char *baseName = strrchr(wds->wibFile, '/');
if (baseName)
wds->wibFH = udcFileMayOpen(baseName+1, NULL);
if ((NULL == baseName) || (wds->wibFH == NULL))
errAbort("findWibFile: failed to open %s", wds->wibFile);
}
}
static void openWibFile(struct wiggleDataStream *wds, char *file)
{
if (wds->wibFile)
{ /* close and open only if different */
if (differentString(wds->wibFile,file))
{
if (wds->wibFH > 0)
udcFileClose(&wds->wibFH);
freeMem(wds->wibFile);
findWibFile(wds, file);
}
}
else
findWibFile(wds, file);
verbose(VERBOSE_HIGHEST, "#\topened wib file: %s\n", wds->wibFile);
}
static void setCompareByte(struct wiggleDataStream *wds,
double lower, double range)
{
if (wds->limit_0 < lower)
wds->ucLowerLimit = 0;
else if (wds->limit_0 > (lower+range))
wds->ucLowerLimit = MAX_WIG_VALUE;
else
wds->ucLowerLimit = MAX_WIG_VALUE * ((wds->limit_0 - lower)/range);
if (wds->limit_1 < lower)
wds->ucUpperLimit = 0;
else if (wds->limit_1 > (lower+range))
wds->ucUpperLimit = MAX_WIG_VALUE + 1; /* +1 because in range is [) */
else
wds->ucUpperLimit = MAX_WIG_VALUE * ((wds->limit_1 - lower)/range);
verbose(VERBOSE_HIGHEST, "#\twigSetCompareByte: [%g : %g] becomes [%d : %d]\n",
lower, lower+range, wds->ucLowerLimit, wds->ucUpperLimit);
}
static void resetStats(float *lowerLimit, float *upperLimit, double *sumData,
double *sumSquares, unsigned long *statsCount, long int *chromStart,
long int *chromEnd)
{
*lowerLimit = INFINITY;
*upperLimit = -1.0 * INFINITY;
*sumData = 0.0;
*sumSquares = 0.0;
*statsCount = 0;
*chromStart = -1;
*chromEnd = 0;
}
static void accumStats(struct wiggleDataStream *wds, float lowerLimit,
float upperLimit, double sumData, double sumSquares,
unsigned statsCount, long int chromStart,
long int chromEnd)
{
if (statsCount > 0)
{
struct wiggleStats *ws;
AllocVar(ws);
ws->chrom = cloneString(wds->currentChrom);
ws->chromStart = chromStart;
ws->chromEnd = chromEnd;
ws->span = wds->currentSpan;
ws->count = statsCount;
ws->lowerLimit = lowerLimit;
ws->dataRange = upperLimit - lowerLimit;
ws->mean = sumData / (double) statsCount;
ws->variance = 0.0;
ws->stddev = 0.0;
if (statsCount > 1)
{
ws->variance = (sumSquares -
((sumData * sumData)/(double) statsCount)) /
(double) (statsCount - 1);
if (ws->variance > 0.0)
ws->stddev = sqrt(ws->variance);
}
slAddHead(&wds->stats, ws);
}
}
static struct bed *bedElement(char *chrom, unsigned start, unsigned end,
unsigned lineCount)
{
struct bed *bed;
char name[128];
AllocVar(bed);
bed->chrom = cloneString(chrom);
bed->chromStart = start;
bed->chromEnd = end;
safef(name, sizeof(name), "%s.%u",
chrom, lineCount);
bed->name = cloneString(name);
return bed;
}
static void closeWibFile(struct wiggleDataStream *wds)
/* if there is a Wib file open, close it */
{
if (wds->wibFH > 0)
udcFileClose(&wds->wibFH);
wds->wibFH = (struct udcFile*)NULL;
if (wds->wibFile)
freez(&wds->wibFile);
}
static void closeWigConn(struct wiggleDataStream *wds)
{
lineFileClose(&wds->lf);
closeWibFile(wds); /* closes only if it is open */
if (wds->conn)
{
sqlFreeResult(&wds->sr);
hFreeConn(&wds->conn);
}
if (wds->sqlConstraint)
freez(&wds->sqlConstraint); /* always reconstructed at open time */
}
static void openWigConn(struct wiggleDataStream *wds)
/* open connection to db or to a file, prepare SQL result for db */
{
if (!wds->tblName)
errAbort("openWigConn: table name missing. setDbTable before open.");
if (wds->isFile)
{
struct dyString *fileName = dyStringNew(256);
lineFileClose(&wds->lf); /* possibly a previous file */
/* don't add .wig if it is already there, or use whatever filename
* was given */
if (fileExists(wds->tblName))
dyStringPrintf(fileName, "%s", wds->tblName);
else
dyStringPrintf(fileName, "%s.wig", wds->tblName);
wds->lf = lineFileOpen(fileName->string, TRUE);
dyStringFree(&fileName);
}
else
{
struct dyString *query = dyStringNew(256);
sqlDyStringPrintf(query, "select * from %s", wds->tblName);
if (wds->chrName)
addConstraint(wds, "chrom", "=", wds->chrName);
if (wds->winEnd)
{
char limits[256];
safef(limits, ArraySize(limits), "%d", wds->winEnd );
addConstraint(wds, "chromStart", "<", limits);
safef(limits, ArraySize(limits), "%d", wds->winStart );
addConstraint(wds, "chromEnd", ">", limits);
}
if (wds->spanLimit)
{
struct dyString *dyTmp = dyStringNew(256);
dyStringPrintf(dyTmp, "%u", wds->spanLimit);
addConstraint(wds, "span", "=", dyTmp->string);
dyStringFree(&dyTmp);
}
if (wds->sqlConstraint)
{
dyStringPrintf(query, " where ");
if (wds->winEnd)
{
hAddBinToQuery(wds->winStart, wds->winEnd, query);
}
dyStringPrintf(query, " (%s)",
wds->sqlConstraint);
}
dyStringPrintf(query, " order by ");
if (!wds->chrName)
dyStringPrintf(query, " chrom ASC,");
if (!wds->spanLimit)
dyStringPrintf(query, " span ASC,");
dyStringPrintf(query, " chromStart ASC");
verbose(VERBOSE_SQL_ROW_LEVEL, "#\t%s\n", query->string);
if (!wds->conn)
wds->conn = hAllocConn(wds->db);
wds->sr = sqlGetResult(wds->conn,query->string);
}
}
static void setDbTable(struct wiggleDataStream *wds, char * db, char *table)
/* sets the DB and table name, determines if table is a file or not */
{
struct dyString *fileName = dyStringNew(256);
if (!table)
errAbort("setDbTable: table specification missing");
/* Check to see if there is a .wig file, or whatever name was given */
if (fileExists(table))
dyStringPrintf(fileName, "%s", table);
else
dyStringPrintf(fileName, "%s.wig", table);
/* file present ignores db specification */
if ((db == (char *)NULL) && fileExists(fileName->string))
wds->isFile = TRUE;
else
{
if (db) /* db can be NULL */
wds->isFile = FALSE; /* assume it will be in the db */
else
errAbort("setDbTable: db is NULL and can not find file %s",
fileName->string);
}
dyStringFree(&fileName);
freeMem(wds->db); /* potentially previously existing */
if (!wds->isFile && db)
wds->db = cloneString(db);
freeMem(wds->tblName); /* potentially previously existing */
wds->tblName = cloneString(table);
}
static char *dateTimeStamp()
{
time_t now = time(NULL);
char *dateTime;
dateTime = sqlUnixTimeToDate(&now,TRUE); /* TRUE == gmTime */
return dateTime;
}
static void outputIdentification(struct wiggleDataStream *wds, FILE *fh)
{
char *dateStamp = dateTimeStamp();
if (wds->db)
fprintf (fh, "#\tdb: '%s', track: '%s', output date: %s UTC\n",
wds->db, wds->tblName, dateStamp);
if (wds->isFile)
fprintf (fh, "#\tfrom file input, output date: %s UTC\n",
dateStamp);
freeMem(dateStamp);
}
static void showResolution(double resolution, FILE *fh)
{
if (resolution > 0.0)
fprintf (fh, "#\tThis data has been compressed with a minor "
"loss in resolution.\n" );
fprintf (fh, "#\t(Worst case: %g) The original source data\n",
resolution);
fprintf (fh, "#\t(before querying and compression) is available at \n"
- "#\t\thttp://hgdownload.cse.ucsc.edu/downloads.html\n");
+ "#\t\thttp://hgdownload.soe.ucsc.edu/downloads.html\n");
}
static void showResolutionNoDownloads(double resolution, FILE *fh)
{
if (resolution > 0.0)
fprintf (fh, "#\tThis data has been compressed with a minor "
"loss in resolution.\n" );
fprintf (fh, "#\t(Worst case: %g)\n", resolution);
}
static void showConstraints(struct wiggleDataStream *wds, FILE *fh)
{
if (wds->chrName)
fprintf (fh, "#\tchrom specified: %s\n", wds->chrName);
if (wds->spanLimit)
fprintf (fh, "#\tspan specified: %u\n", wds->spanLimit);
if (wds->winEnd)
fprintf (fh, "#\tposition specified: %d-%d\n",
BASE_1(wds->winStart), wds->winEnd);
if (wds->bedConstrained && !wds->chrName)
fprintf (fh, "#\tconstrained by chr names and coordinates in bed list\n");
else if (wds->bedConstrained)
fprintf (fh, "#\tconstrained by coordinates in bed list\n");
wigPrintDataConstraint(wds, fh);
}
static int arrayDataCmp(const void *va, const void *vb)
/* Compare to sort based on chrom,winStart */
{
const struct wiggleArray *a = *((struct wiggleArray **)va);
const struct wiggleArray *b = *((struct wiggleArray **)vb);
int dif;
dif = chrStrippedCmp(a->chrom, b->chrom);
if (dif == 0)
dif = a->winStart - b->winStart;
return dif;
}
static int asciiDataCmp(const void *va, const void *vb)
/* Compare to sort based on chrom,span,chromStart. */
{
const struct wigAsciiData *a = *((struct wigAsciiData **)va);
const struct wigAsciiData *b = *((struct wigAsciiData **)vb);
int dif;
dif = chrStrippedCmp(a->chrom, b->chrom);
if (dif == 0)
{
dif = a->span - b->span;
if (dif == 0)
dif = a->data->chromStart - b->data->chromStart;
}
return dif;
}
static int statsDataCmp(const void *va, const void *vb)
/* Compare to sort based on chrom,span,chromStart. */
{
const struct wiggleStats *a = *((struct wiggleStats **)va);
const struct wiggleStats *b = *((struct wiggleStats **)vb);
int dif;
dif = chrStrippedCmp(a->chrom, b->chrom);
if (dif == 0)
{
dif = a->span - b->span;
if (dif == 0)
dif = a->chromStart - b->chromStart;
}
return dif;
}
/* currently this dataArrayOut is private, but it may become public */
static void dataArrayOut(struct wiggleDataStream *wds, char *fileName,
boolean rawDataOut, boolean sort)
/* print to fileName ascii data values from the first list element
* of the data "array" results */
{
FILE * fh;
fh = mustOpen(fileName, "w");
if (wds->array)
{
unsigned pointCount;
unsigned chromPosition;
unsigned inx;
float *dataPtr;
if (sort)
slSort(&wds->array, arrayDataCmp);
dataPtr = wds->array->data;
/* user visible coordinates are wds->offset relative/based */
chromPosition = wds->array->winStart + wds->offset;
pointCount = wds->array->winEnd - wds->array->winStart;
for (inx = 0; inx < pointCount; ++inx)
{
if (!isnan(*dataPtr))
{
if (rawDataOut)
fprintf (fh, "%g\n", *dataPtr);
else
fprintf (fh, "%u\t%g\n", chromPosition, *dataPtr);
}
++dataPtr;
++chromPosition;
}
}
else
{
if (!rawDataOut)
{
showConstraints(wds, fh);
fprintf(fh, "#\tdataArray: no data points found\n");
}
}
carefulClose(&fh);
} /* static void dataArrayOut() */
/* PUBLIC METHODS **************************************************/
static void setMaxOutput(struct wiggleDataStream *wds,
unsigned long long maxOut)
/* set the maximum # of values to return */
{
wds->maxOutput = maxOut;
verbose(VERBOSE_CHR_LEVEL,"#\tsetMaxOutput: %llu\n", wds->maxOutput);
}
static void setPositionConstraint(struct wiggleDataStream *wds,
int winStart, int winEnd)
/* both 0 means no constraint */
{
if ((!wds->isFile) && wds->conn)
{ /* this should not happen */
errAbort("setPositionConstraint: not allowed after openWigConn()");
}
/* keep them in proper order */
if (winStart > winEnd)
{
wds->winStart = winEnd;
wds->winEnd = winStart;
}
else if ((winEnd > 0) && (winStart == winEnd))
errAbort(
"setPositionConstraint: can not have winStart == winEnd (%d == %d)",
winStart, winEnd);
else
{
wds->winStart = winStart;
wds->winEnd = winEnd;
}
verbose(VERBOSE_SQL_ROW_LEVEL,"#\tsetPosition: %d - %d\n", wds->winStart, wds->winEnd);
}
static void setChromConstraint(struct wiggleDataStream *wds, char *chr)
{
freeMem(wds->chrName); /* potentially previously existing */
wds->chrName = cloneString(chr);
}
static void setSpanConstraint(struct wiggleDataStream *wds, unsigned span)
{
wds->spanLimit = span;
}
static void freeConstraints(struct wiggleDataStream *wds)
/* free the position, span, chrName and data constraints */
{
wds->spanLimit = 0;
wds->setPositionConstraint(wds, 0, 0);
if (wds->chrName)
freez(&wds->chrName);
if (wds->dataConstraint)
freez(&wds->dataConstraint);
wds->wigCmpSwitch = wigNoOp_e;
wds->limit_0 = wds->limit_1 = 0.0;
wds->ucLowerLimit = wds->ucUpperLimit = 0;
if (wds->sqlConstraint)
freez(&wds->sqlConstraint);
wds->useDataConstraint = FALSE;
wds->bedConstrained = FALSE;
}
static void freeAscii(struct wiggleDataStream *wds)
/* free the wiggleAsciiData list */
{
if (wds->ascii)
{
struct wigAsciiData *el, *next;
for (el = wds->ascii; el != NULL; el = next)
{
next = el->next;
freeMem(el->chrom);
freeMem(el->data);
freeMem(el);
}
}
wds->ascii = NULL;
}
static void freeBed(struct wiggleDataStream *wds)
/* free the wiggle bed list */
{
bedFreeList(&wds->bed);
}
static void freeArray(struct wiggleDataStream *wds)
/* free the wiggleArray list */
{
if (wds->array)
{
struct wiggleArray *wa;
struct wiggleArray *next;
for (wa = wds->array; wa; wa = next)
{
next = wa->next;
freeMem(wa->chrom);
freeMem(wa->data);
freeMem(wa);
}
}
wds->array = NULL;
}
static void freeStats(struct wiggleDataStream *wds)
/* free the wiggleStats list */
{
if (wds->stats)
{
struct wiggleStats *el, *next;
for (el = wds->stats; el != NULL; el = next)
{
next = el->next;
freeMem(el->chrom);
freeMem(el);
}
}
wds->stats = NULL;
}
enum wigCompare wigCompareFromString(char *string)
/* Given a string return corresponding cmp code. */
{
if (sameWord(string,"<"))
return wigLessThan_e;
else if (sameWord(string,"<="))
return wigLessEqual_e;
else if (sameWord(string,"="))
return wigEqual_e;
else if (sameWord(string,"!="))
return wigNotEqual_e;
else if (sameWord(string,">="))
return wigGreaterEqual_e;
else if (sameWord(string,">"))
return wigGreaterThan_e;
else if (sameWord(string,"in range"))
return wigInRange_e;
else
{
errAbort("wigSetCompareFunctions: unknown constraint: '%s'", string);
return wigLessThan_e;
}
}
/* the double comparison functions
* used to check the wiggle SQL rows which are a bucket of values
* between *lower and *upper. Therefore, the value to be checked
* which is in wds->limit_0 (and wds->limit_1 in the case of
* a range) needs to be compared to the bucket of values. If it
* falls within the specified range, then it is considered to be in
* that bucket.
*/
/* InRange means the SQL row begins before the limit_1 (lower=limit_0)
* i.e. there is at least some overlap of the range
* This is a half open inquiry: [ limit_0 : limit_1 )
*/
/* LessThan means: the row begins before the limit_0 (valuedataConstraint)
return;
wds->wigCmpSwitch = wigCompareFromString(wds->dataConstraint);
}
static void setDataConstraint(struct wiggleDataStream *wds,
char *dataConstraint, double lowerLimit, double upperLimit)
{
freeMem(wds->dataConstraint); /* potentially previously existing */
wds->dataConstraint = cloneString(dataConstraint);
if (differentWord(wds->dataConstraint, "in range"))
{
wds->limit_0 = lowerLimit;
}
else
{
if (lowerLimit < upperLimit)
{
wds->limit_0 = lowerLimit;
wds->limit_1 = upperLimit;
}
else if (!(upperLimit < lowerLimit))
errAbort("wigSetDataConstraint: upper and lower limits are equal: %g == %g",
lowerLimit, upperLimit);
else
{
wds->limit_0 = upperLimit;
wds->limit_1 = lowerLimit;
}
}
wigSetCompareFunctions(wds);
wds->useDataConstraint = TRUE;
}
boolean wigCompareValFilter(double val, enum wigCompare cmp, double ll, double ul)
/* Return TRUE if val passes comparison filter. */
{
boolean takeIt = FALSE;
switch (cmp)
{
case wigNoOp_e:
takeIt = TRUE;
break;
case wigInRange_e:
takeIt = (val < ul) &&
(val >= ll);
break;
case wigLessThan_e:
takeIt = val < ll;
break;
case wigLessEqual_e:
takeIt = val <= ll;
break;
case wigEqual_e:
takeIt = val == ll;
break;
case wigNotEqual_e:
takeIt = val != ll;
break;
case wigGreaterEqual_e:
takeIt = val >= ll;
break;
case wigGreaterThan_e:
takeIt = val > ll;
break;
default:
errAbort("wigCmpValFilter: illegal wigCmpSwitch ? %#x", cmp);
break;
}
return takeIt;
}
static unsigned long long getData(struct wiggleDataStream *wds, char *db,
char *table, int operations)
/* getData - read and return wiggle data */
{
char *row[WIGGLE_NUM_COLS+1]; /* potentially a bin column too */
unsigned long long rowCount = 0;
unsigned long long validData = 0;
unsigned long long valuesMatched = 0;
unsigned long long noDataBytes = 0;
unsigned long long bytesSkipped = 0;
boolean doRawStats = FALSE;
boolean doStats = FALSE;
boolean doBed = FALSE;
boolean doAscii = FALSE;
boolean doDataArray = FALSE;
boolean doNoOp = FALSE;
boolean skipDataRead = FALSE; /* may need this later */
float lowerLimit = INFINITY;
float upperLimit = -1.0 * INFINITY;
double sumData = 0.0;
double sumSquares = 0.0;
unsigned long statsCount = 0;
long int chromStart = -1;
long int chromEnd = 0;
boolean summaryOnly = TRUE;
unsigned bedElStart = 0;
unsigned bedElEnd = 0;
unsigned bedElCount = 0;
boolean firstSpanDone = FALSE; /* to prevent multiple bed lists */
float *dataArrayPtr = NULL; /* to access the data array values */
unsigned dataArrayPosition = 0; /* marches thru all from beginning to end */
struct wiggle *wiggle; /* one SQL data read results */
boolean maxReached = FALSE;
doAscii = operations & wigFetchAscii;
doDataArray = operations & wigFetchDataArray;
doBed = operations & wigFetchBed;
doRawStats = operations & wigFetchRawStats;
doStats = (operations & wigFetchStats) || doRawStats;
doNoOp = operations & wigFetchNoOp;
/* for timing purposes, allow the wigFetchNoOp to go through */
if (doNoOp)
doDataArray = doBed = doStats = doAscii = FALSE;
if (! (doNoOp || doAscii || doDataArray || doBed || doStats) )
{
verbose(VERBOSE_CHR_LEVEL, "getData: no type of data fetch requested ?\n");
return(valuesMatched); /* NOTHING ASKED FOR ? */
}
/* not going to do this without a range specified and a chr name */
if (doDataArray && wds->winEnd && wds->chrName)
{
long startTime = 0;
struct wiggleArray *wa;
size_t inx, size;
size_t winSize;
unsigned long long hugeSize;
AllocVar(wa);
wa->chrom = cloneString(wds->chrName);
wa->winStart = wds->winStart;
wa->winEnd = wds->winEnd;
winSize = wa->winEnd - wa->winStart;
hugeSize = (unsigned long long)sizeof(float) * (unsigned long long)winSize;
if (sizeof(size_t) == 4)
{
if (hugeSize > HUGE_LIMIT)
{
warn("ERROR: Can not perform requested data operation.
");
errAbort("Not enough memory (requested: %llu bytes)", hugeSize);
}
}
size = sizeof(float) * winSize;
setMaxAlloc((size_t)HUGE_LIMIT);
if (verboseLevel() >= VERBOSE_CHR_LEVEL)
startTime = clock1000();
wa->data = (float *)needLargeMem(size);
dataArrayPtr = wa->data;
/* this init loop turns out to be quite fast, even for huge arrays */
for (inx = 0; inx < winSize; ++inx)
*dataArrayPtr++ = NAN;
dataArrayPtr = wa->data;
dataArrayPosition = wa->winStart;
slAddHead(&wds->array, wa);
if (verboseLevel() >= VERBOSE_CHR_LEVEL)
{
long et = clock1000() - startTime;
verbose(VERBOSE_CHR_LEVEL,
"#\tgetData: created data array for %lld values (%llu b) in %ld ms\n",
(unsigned long long)winSize, (unsigned long long)size, et);
verbose(VERBOSE_CHR_LEVEL,
"#\tdata array begins at %#lx, last at %#lx, size: %#lx\n",
(unsigned long) dataArrayPtr,
(unsigned long) (((unsigned long) dataArrayPtr) +
((unsigned long) size)), (unsigned long) size);
}
}
else if (doDataArray && !(doNoOp || doAscii || doBed || doStats))
{
verbose(VERBOSE_CHR_LEVEL,
"getData: must specify a chrom range to FetchDataArray\n");
return(valuesMatched); /* NOTHING ASKED FOR ? */
}
setDbTable(wds, db, table);
openWigConn(wds);
if (doStats && wds->useDataConstraint)
summaryOnly = FALSE;
if (doDataArray)
summaryOnly = FALSE;
if (doAscii)
summaryOnly = FALSE;
if (doBed)
summaryOnly = FALSE;
if (wds->winEnd)
summaryOnly = FALSE;
/* nextRow() produces the next SQL row from either DB or file.
*
* The unusual use of wiggleFree() as the third element of this for()
* loop is to take care of the condition when the 'continue;'
* statements are used to skip the loop and not have to worry about
* what happens at the end of the loop. the wiggleFree() must be
* done at the end of each loop even in the case of 'continue;' or
* not. This is the single instance of wiggleFree() in the entire
* source file, as it should be.
*/
for ( ; (!maxReached) && nextRow(wds, row, WIGGLE_NUM_COLS);
wiggleFree(&wiggle) )
{
struct wigAsciiData *wigAscii = NULL;
struct asciiDatum *asciiOut = NULL; /* to address data[] in wigAsciiData */
unsigned chromPosition;
boolean range0TakesAll = FALSE;
if (doRawStats)
{
accumStats(wds, lowerLimit, upperLimit, sumData, sumSquares,
statsCount, chromStart, chromEnd);
resetStats(&lowerLimit, &upperLimit, &sumData, &sumSquares,
&statsCount, &chromStart, &chromEnd);
}
++rowCount;
wiggle = wiggleLoad(row);
/* constraints have to be done manually for files */
if (wds->isFile)
{
/* if chrName is not correct, or span is not correct,
* or outside of window, go to next SQL row
*/
if (
((wds->chrName) && (differentString(wds->chrName,wiggle->chrom))) ||
((wds->spanLimit) && (wds->spanLimit != wiggle->span)) ||
((wds->winEnd) && ((wiggle->chromStart >= wds->winEnd) ||
(wiggle->chromEnd < wds->winStart)) )
)
{
bytesSkipped += wiggle->count;
continue; /* next SQL row */
}
}
chromPosition = wiggle->chromStart;
/* this will be true the very first time for both reasons */
if ( (wds->currentSpan != wiggle->span) ||
(wds->currentChrom &&
differentString(wds->currentChrom, wiggle->chrom)))
{
/* if we have been working on one, then doBed */
if (!firstSpanDone && doBed && wds->currentChrom)
{
if (bedElEnd > bedElStart)
{
struct bed *bedEl;
bedEl = bedElement(wds->currentChrom,
bedElStart, bedElEnd, ++bedElCount);
slAddHead(&wds->bed, bedEl);
}
bedElStart = 0;
bedElEnd = 0;
bedElCount = 0;
}
if (wds->currentSpan && (wds->currentSpan != wiggle->span))
firstSpanDone = TRUE;
if (wds->currentChrom &&
differentString(wds->currentChrom, wiggle->chrom))
firstSpanDone = FALSE;
/* if we have been working on one, then doStats */
if (doStats && wds->currentChrom)
{
accumStats(wds, lowerLimit, upperLimit, sumData, sumSquares,
statsCount, chromStart, chromEnd);
resetStats(&lowerLimit, &upperLimit, &sumData, &sumSquares,
&statsCount, &chromStart, &chromEnd);
}
freeMem(wds->currentChrom);
/* set them whether they are changing or not, doesn't matter */
wds->currentChrom = cloneString(wiggle->chrom);
wds->currentSpan = wiggle->span;
}
/* it may seem inefficient to make one of these for each SQL row,
* but the alternative would require expanding the data area for
* each row and thus a re-alloc - probably more expensive than
* just making one of these for each row.
*/
if (doAscii)
{
AllocVar(wigAscii);
wigAscii->chrom = cloneString(wiggle->chrom);
wigAscii->span = wiggle->span;
wigAscii->count = 0; /* will count up as values added */
wigAscii->dataRange = wiggle->dataRange; /* for resolution calc */
wigAscii->data = (struct asciiDatum *) needMem((size_t)
(sizeof(struct asciiDatum) * wiggle->validCount));
asciiOut = wigAscii->data;
slAddHead(&wds->ascii,wigAscii);
}
verbose(VERBOSE_SQL_ROW_LEVEL,
"#\trow: %llu, start: %u, data range: %g: [%g:%g], resolution: %g per bin\n",
rowCount, wiggle->chromStart, wiggle->dataRange,
wiggle->lowerLimit, wiggle->lowerLimit+wiggle->dataRange,
wiggle->dataRange/(double)MAX_WIG_VALUE);
if (wds->useDataConstraint)
{
boolean takeIt = FALSE;
switch (wds->wigCmpSwitch)
{
case wigNoOp_e:
takeIt = TRUE;
break;
case wigInRange_e:
takeIt = (wiggle->lowerLimit < wds->limit_1) &&
((wiggle->lowerLimit + wiggle->dataRange) >=
wds->limit_0);
break;
case wigLessThan_e:
takeIt = wiggle->lowerLimit < wds->limit_0;
break;
case wigLessEqual_e:
takeIt = wiggle->lowerLimit <= wds->limit_0;
break;
case wigEqual_e:
takeIt = (wiggle->lowerLimit <= wds->limit_0) &&
(wds->limit_0 <=
(wiggle->lowerLimit + wiggle->dataRange));
break;
case wigNotEqual_e:
takeIt = (wds->limit_0 < wiggle->lowerLimit) ||
((wiggle->lowerLimit + wiggle->dataRange) <
wds->limit_0);
break;
case wigGreaterEqual_e:
takeIt = wds->limit_0 <=
(wiggle->lowerLimit + wiggle->dataRange);
break;
case wigGreaterThan_e:
takeIt = wds->limit_0 <
(wiggle->lowerLimit + wiggle->dataRange);
break;
default:
errAbort("wig_getData: illegal wigCmpSwitch ? %#x",
wds->wigCmpSwitch);
break;
} /* switch (wds->wigCmpSwitch) */
if (0.0 == wiggle->dataRange)
range0TakesAll = takeIt;
if (takeIt)
setCompareByte(wds, wiggle->lowerLimit, wiggle->dataRange);
else
{
verbose(VERBOSE_HIGHEST,
"#\tthis row fails compare, next SQL row\n");
bytesSkipped += wiggle->count;
continue; /* next SQL row */
}
}
if (summaryOnly && doStats)
{
/* record maximum limits of data values */
if (wiggle->lowerLimit < lowerLimit)
lowerLimit = wiggle->lowerLimit;
if (wiggle->lowerLimit+wiggle->dataRange > upperLimit)
upperLimit = wiggle->lowerLimit+wiggle->dataRange;
sumData += wiggle->sumData;
sumSquares += wiggle->sumSquares;
/* record maximum extents */
if ((chromStart < 0)||(chromStart > wiggle->chromStart))
chromStart = wiggle->chromStart;
if (chromEnd < wiggle->chromEnd)
chromEnd = wiggle->chromEnd;
statsCount += wiggle->validCount;
valuesMatched += wiggle->validCount;
bytesSkipped += wiggle->count;
continue; /* next SQL row */
}
if (!skipDataRead)
{
int j; /* loop counter through readData */
unsigned char *datum; /* to walk through readData bytes */
unsigned char *readData; /* the bytes read in from the file */
size_t bytesToRead; /* to check read validity */
size_t bytesRead; /* to check read validity */
openWibFile(wds, wiggle->file);
/* possibly open a new wib file */
readData = (unsigned char *) needMem((size_t) (wiggle->count + 1));
wds->bytesRead += wiggle->count;
udcSeek(wds->wibFH, wiggle->offset);
bytesToRead = (size_t) wiggle->count * (size_t) sizeof(unsigned char);
bytesRead = udcRead(wds->wibFH, readData, bytesToRead);
if (bytesToRead != bytesRead)
{
errAbort("wig_getData: failed to read %llu bytes from %s\n",
(unsigned long long)bytesToRead, wiggle->file);
}
verbose(VERBOSE_PER_VALUE_LEVEL,
"#\trow: %llu, reading: %u bytes\n", rowCount, wiggle->count);
/* The third element of the for() statement takes care of the end
* of loop operations for the case of the 'continue;'
* statement as well as the normal end of loop business
*/
datum = readData;
for (j = 0; j < wiggle->count;
++datum, chromPosition += wiggle->span, ++j)
{
if (wds->maxOutput)
{
if (doAscii)
{
/* previous results to this fetch are wds->valuesMatched
* this result is currently at valuesMatched
*/
if (wds->maxOutput <= (wds->valuesMatched + valuesMatched))
{
maxReached = TRUE;
break;
}
}
if (doBed)
{
/* previous results to this fetch are
* wds->totalBedElements, this result is currently
* at bedElCount. The -1 is because there is
* one more bed element to go upon exit from
* this loop.
*/
if ( (wds->totalBedElements + bedElCount) >=
(wds->maxOutput - 1) )
{
maxReached = TRUE;
break;
}
}
}
if (*datum != WIG_NO_DATA)
{
boolean takeIt = FALSE;
if (wds->winEnd) /* non-zero means a range is in effect */
{ /* do not allow item (+span) to run over winEnd */
unsigned span = wiggle->span;
/* if only doing data array, span is 1 */
if (doDataArray && !(doStats || doBed || doStats))
span = 1;
if ( (chromPosition < wds->winStart) ||
((chromPosition+span) > wds->winEnd) )
continue; /* next *datum */
}
++validData;
switch (wds->wigCmpSwitch)
{
case wigNoOp_e:
takeIt = TRUE;
break;
case wigInRange_e:
takeIt = (*datum < wds->ucUpperLimit) &&
(*datum >= wds->ucLowerLimit);
break;
case wigLessThan_e:
takeIt = *datum < wds->ucLowerLimit;
break;
case wigLessEqual_e:
takeIt = *datum <= wds->ucLowerLimit;
break;
case wigEqual_e:
takeIt = *datum == wds->ucLowerLimit;
break;
case wigNotEqual_e:
takeIt = *datum != wds->ucLowerLimit;
break;
case wigGreaterEqual_e:
takeIt = *datum >= wds->ucLowerLimit;
break;
case wigGreaterThan_e:
takeIt = *datum > wds->ucLowerLimit;
break;
default:
errAbort("wig_getData: illegal wigCmpSwitch ? %#x",
wds->wigCmpSwitch);
break;
} /* switch (wds->wigCmpSwitch) */
if (range0TakesAll || takeIt)
{
float value = 0.0;
++valuesMatched;
if (doAscii || doStats || doDataArray || doNoOp)
value = BIN_TO_VALUE(*datum,
wiggle->lowerLimit,wiggle->dataRange);
if (doAscii)
{
asciiOut->value = value;
asciiOut->chromStart = chromPosition;
++asciiOut;
++wigAscii->count;
}
if (!firstSpanDone && doDataArray)
{
unsigned span = wiggle->span;
unsigned inx;
long long gap = (long long) chromPosition -
(long long) dataArrayPosition;
if (verboseLevel() >= VERBOSE_CHR_LEVEL)
{
if (chromPosition < dataArrayPosition)
verbose(VERBOSE_CHR_LEVEL,
"#\tWARNING: coordinates out of order %s %u < %u\n",
wiggle->chrom, chromPosition, dataArrayPosition);
}
dataArrayPosition += gap;
/* special case squeezing into the end */
if ((dataArrayPosition + span) > wds->winEnd)
span = wds->winEnd - dataArrayPosition;
dataArrayPtr += gap; /* move up, leave NaN's */
verbose(VERBOSE_PER_VALUE_LEVEL, "#\t%u-%u <- %g\n",
dataArrayPosition,
dataArrayPosition + span, value);
/* fill all chrom positions for this element */
for (inx = 0; inx < span; ++inx)
*dataArrayPtr++ = value;
dataArrayPosition += span;
}
/* beware, coords must come in sequence for this to
* work. The original SQL query should be ordering
* things properly. We only do the first span
* encountered, it should be the lowest due to the
* SQL query.
*/
if (!firstSpanDone && doBed)
{
/* as long as they are continuous, keep
* extending the end
*/
if (chromPosition == bedElEnd)
bedElEnd += wiggle->span;
else
{ /* if one was collected, output it */
if (bedElEnd > bedElStart)
{
struct bed *bedEl;
bedEl = bedElement(wiggle->chrom,
bedElStart, bedElEnd, ++bedElCount);
slAddHead(&wds->bed, bedEl);
}
/* start a new element here */
bedElStart = chromPosition;
bedElEnd = bedElStart + wiggle->span;
}
}
if (doStats)
{
/* record maximum data limits */
if (value < lowerLimit)
lowerLimit = value;
if (value > upperLimit)
upperLimit = value;
sumData += value;
sumSquares += value * value;
/* record maximum extents */
if ((chromStart < 0)||(chromStart > chromPosition))
chromStart = chromPosition;
if (chromEnd < (chromPosition + wiggle->span))
chromEnd = chromPosition + wiggle->span;
++statsCount;
}
}
} /* if (*datum != WIG_NO_DATA) */
else
{
++noDataBytes;
}
} /* for (j = 0; j < wiggle->count; ++j) */
freeMem(readData);
} /* if (!skipDataRead) */
} /* for ( ; nextRow(wds, row, WIGGLE_NUM_COLS); ... ) */
/* there may be one last bed element to output */
if (!firstSpanDone && doBed)
{
if (bedElEnd > bedElStart)
{
struct bed *bedEl;
bedEl = bedElement(wds->currentChrom,
bedElStart, bedElEnd, ++bedElCount);
slAddHead(&wds->bed, bedEl);
}
}
/* there are accumulated stats to complete */
if (doStats)
{
accumStats(wds, lowerLimit, upperLimit, sumData, sumSquares,
statsCount, chromStart, chromEnd);
resetStats(&lowerLimit, &upperLimit, &sumData, &sumSquares,
&statsCount, &chromStart, &chromEnd);
}
wds->rowsRead += rowCount;
wds->validPoints += validData;
wds->valuesMatched += valuesMatched;
wds->noDataPoints += noDataBytes;
wds->bytesSkipped += bytesSkipped;
wds->totalBedElements += bedElCount;
closeWigConn(wds);
return(valuesMatched);
} /* unsigned long long getData() */
static float *asciiToDataArray(struct wiggleDataStream *wds,
unsigned long long count, size_t *returned)
/* convert the AsciiData list to a float array */
{
float *floatArray = NULL;
float *fptr = NULL;
unsigned long long valuesDone = 0;
struct wigAsciiData *asciiData = NULL;
if (count < 1)
return floatArray;
setMaxAlloc((size_t)HUGE_LIMIT);
AllocArray(floatArray, count);
fptr = floatArray;
/* the (valuesDone <= count) condition is for safety */
for (asciiData = wds->ascii; asciiData && (valuesDone < count);
asciiData = asciiData->next)
{
if (asciiData->count)
{
struct asciiDatum *data;
unsigned i;
data = asciiData->data;
for (i = 0; (i < asciiData->count)&&(valuesDone < count); ++i)
{
*fptr++ = data->value;
++data;
++valuesDone;
}
}
}
if (returned)
*returned = valuesDone;
return floatArray;
}
static unsigned long long getDataViaBed(struct wiggleDataStream *wds, char *db,
char *table, int operations, struct bed **bedList)
/* getDataViaBed - constrained by the bedList */
{
unsigned long long valuesMatched = 0;
unsigned long long prevValuesMatched = 0;
if (bedList && *bedList)
{
struct bed *filteredBed = NULL;
boolean chromConstraint = ((char *)NULL != wds->chrName);
boolean positionConstraints = (0 != wds->winEnd);
int saveWinStart = 0;
int saveWinEnd = 0;
char * saveChrName = NULL;
struct slName *chromList = NULL;
struct slName *chr;
struct hash *chromSizes = NULL;
struct { unsigned long chrStart; unsigned long chrEnd; } *chrStartEnd;
unsigned long long valuesFound = 0;
boolean maxReached = FALSE;
unsigned long long prevMaxOutput = 0;
/* remember these constraints so we can reset them afterwards
* because we are going to use them for our own internal uses here.
*/
saveWinStart = wds->winStart;
saveWinEnd = wds->winEnd;
chromSizes = newHash(0);
/* Determine what will control which chrom to do. If a chrom
* constraint has been set then that is the one to do. If it has
* not been set, then allow the bedList to be the list of chroms to
* do. This business finds the maximum extent for each chrom in
* the bedList.
*/
if (chromConstraint)
{
saveChrName = cloneString(wds->chrName);
chr = newSlName(wds->chrName);
slAddHead(&chromList, chr);
AllocVar(chrStartEnd);
chrStartEnd->chrStart = wds->winStart;
chrStartEnd->chrEnd = wds->winEnd;
hashAdd(chromSizes, wds->chrName, chrStartEnd);
}
else
{
struct bed *bed = NULL;
for (bed = *bedList; bed; bed = bed->next)
{
/* out of order bed file ? Maybe already saw this name */
if (hashLookup(chromSizes, bed->chrom) != NULL)
{
chrStartEnd = hashFindVal(chromSizes, bed->chrom);
chrStartEnd->chrStart = min(bed->chromStart,chrStartEnd->chrStart);
chrStartEnd->chrEnd = max(bed->chromEnd, chrStartEnd->chrEnd);
}
else
{
chr = newSlName(bed->chrom);
slAddHead(&chromList, chr);
AllocVar(chrStartEnd);
chrStartEnd->chrStart = bed->chromStart;
chrStartEnd->chrEnd = bed->chromEnd;
hashAdd(chromSizes, bed->chrom, chrStartEnd);
}
}
slReverse(&chromList);
}
/* OK, the chromList and chromSizes hash have been created, run
* through that list. This may seem unusual, but if the caller has
* set position constraints but no chr constraint, allow those
* constraints to override
* the bedList coordinates, even though we may be running through a
* number of chroms. That's what they wanted, that's what they get.
* e.g. they wanted the first 10,000 bases of each chrom,
* winStart=0, winEnd = 10,000, no chrName specified
*/
for (chr = chromList; (!maxReached) && chr; chr = chr->next)
{
long startTime = 0;
float *fptr;
boolean doAscii = FALSE;
boolean doBed = FALSE;
boolean doStats = FALSE;
boolean doNoOp = FALSE;
boolean doDataArray = FALSE;
struct bed *bed;
unsigned long bedExtent = 0; /* from first thru last element of bedList*/
unsigned long bedStart = 0;
unsigned long bedEnd = 0;
unsigned long bedPosition = 0;
char *bedArray; /* meaning is boolean but */
char *boolPtr; /* boolean is 4 bytes, char is 1 */
unsigned long bedArraySize = 0;
unsigned long winStart = 0;
unsigned long winEnd = 0;
unsigned long winExtent = 0;
unsigned long bedMarked = 0;
unsigned long asciiDataSizeLimit = 0;
unsigned long chromPosition = 0;
unsigned long bedElStart = 0;
unsigned long bedElEnd = 0;
unsigned long bedElCount = 0;
float lowerLimit = INFINITY; /* stats accumulators */
float upperLimit = -1.0 * INFINITY; /* stats accumulators */
double sumData = 0.0; /* stats accumulators */
double sumSquares = 0.0; /* stats accumulators */
unsigned long statsCount = 0; /* stats accumulators */
long int chromStart = -1; /* stats accumulators */
long int chromEnd = 0; /* stats accumulators */
size_t dataArraySize = 0;
doDataArray = operations & wigFetchDataArray;
/* set chrom name constraint */
wds->setChromConstraint(wds, (char *)&chr->name);
chrStartEnd = hashFindVal(chromSizes, wds->chrName);
if (NULL == chrStartEnd)
errAbort("getDataViaBed: constructed hash of bed coords is broken");
/* This may seem unusual, but if the caller has
* set position constraints, allow those constraints to override
* the bedList coordinates, even though we may be running through
* a number of chroms.
*/
if (saveWinEnd)
{
winStart = saveWinStart;
winEnd = saveWinEnd;
}
else
{
winStart = chrStartEnd->chrStart;
winEnd = chrStartEnd->chrEnd;
}
/* winExtent could still be 0 here */
/* remember this window extent */
winExtent = winEnd - winStart;
/* set window position constraint */
wds->setPositionConstraint(wds, winStart, winEnd);
/* Going to create a TRUE/FALSE marker array from the bedList.
* Each chrom position will be marked TRUE if it belongs to
* a bed element. Overlapping bed elements will be
* redundant and a waste of time, but no real problem.
* Filter by the chr name and the win limits.
*/
for (bed = *bedList; bed; bed = bed->next)
{
if (sameString(wds->chrName, bed->chrom))
{
/* if (no limits) OR (within limits) use it */
if (!(winEnd) || ( (bed->chromStart < winEnd) &&
(bed->chromEnd >= winStart)) )
{
struct bed *newBed = cloneBed(bed);
slAddHead(&filteredBed, newBed);
}
}
}
if (NULL == filteredBed)
{
verbose(VERBOSE_CHR_LEVEL,
"#\tfilter found nothing in bed file: %s:%lu-%lu\n",
wds->chrName, winStart, winEnd);
continue; /* next chrom */
}
else
slSort(&filteredBed,bedCmp); /* in proper order */
if (verboseLevel() >= VERBOSE_CHR_LEVEL)
{
int count=slCount(filteredBed);
verbose(VERBOSE_CHR_LEVEL,
"#\tfiltered by chr,pos constraints, bed el count: %d\n",
count);
}
/* determine actual limits loaded by the filter */
bedStart = min(winStart,filteredBed->chromStart);
bedEnd = filteredBed->chromEnd;
for (bed = filteredBed; bed; bed = bed->next)
{
if (bed->chromStart < bedStart)
bedStart = bed->chromStart;
if (bed->chromEnd > bedEnd)
bedEnd = bed->chromEnd;
}
bedExtent = bedEnd - bedStart;
/* must use the larger of the two sizes */
bedArraySize = max(winExtent,bedExtent);
bedArraySize *= sizeof(char); /* in bytes */
setMaxAlloc((size_t)HUGE_LIMIT);
if (verboseLevel() >= VERBOSE_CHR_LEVEL)
startTime = clock1000();
bedArray = (char *)needLargeMem(bedArraySize);
verbose(VERBOSE_CHR_LEVEL,
"#\tbed array begins at %#lx, last at %#lx, size: %#lx\n",
(unsigned long) bedArray,
(unsigned long) (((unsigned long) bedArray) +
((unsigned long) bedArraySize)),
(unsigned long) bedArraySize );
/* set them all to FALSE to begin with */
memset((void *)bedArray, FALSE, bedArraySize);
if (verboseLevel() >= VERBOSE_CHR_LEVEL)
{
long et = clock1000() - startTime;
verbose(VERBOSE_CHR_LEVEL,
"#\tgetDataViaBed: created data array for %lu bed indicators in %ld ms\n",
bedArraySize, et);
}
/* use the bed definition to fill this marker array */
/* start at the lesser of the two start positions */
bedPosition = min(winStart, bedStart);
bedStart = bedPosition;
boolPtr = bedArray;
bedEnd = filteredBed->chromEnd;
for (bed = filteredBed; bed; bed = bed->next)
{
unsigned long elSize = bed->chromEnd - bed->chromStart;
boolPtr = bedArray + (bed->chromStart - bedStart);
memset((void *)boolPtr, TRUE, elSize);
boolPtr += elSize;
bedPosition = (unsigned long)((void *)boolPtr - (void *)bedArray);
bedMarked += elSize; /* number of bases marked */
bedEnd = max(bedEnd, bed->chromEnd);
}
bedExtent = bedEnd - bedStart;
verbose(VERBOSE_CHR_LEVEL,
"#\tbed range %lu = %lu - %lu, allocated %lu bytes\n",
bedExtent, bedEnd, bedStart, bedArraySize);
verbose(VERBOSE_CHR_LEVEL, "#\tbed marked %lu bases, winSize %lu\n",
bedMarked, winExtent);
/* worst case ascii limit: bedMarked */
asciiDataSizeLimit = bedMarked;
/*set window position constraint, this eliminates the 0,0 possibility*/
if (winEnd)
{
winStart = max(bedStart, winStart);
winEnd = min(bedEnd, winEnd);
}
else
{
winStart = bedStart;
winEnd = bedEnd;
}
/* must have actual positions for constraints for getData
* to do this wigFetchDataArray function.
*/
wds->setPositionConstraint(wds, winStart, winEnd);
/* now fetch all the wiggle data for this position,
* constraints have been set at the top of this loop
*/
/* POTENTIAL SPEEDUP here, if only bed results are
* the requested result, then we should just ask for a bed
* list from getData and simply intersect that bed list
* with the given bed list filter.
*/
prevValuesMatched = wds->valuesMatched;
prevMaxOutput = wds->maxOutput;
wds->maxOutput = 0;
valuesFound = wds->getData(wds, db, table, wigFetchDataArray);
wds->valuesMatched = prevValuesMatched;
wds->maxOutput = prevMaxOutput;
verbose(VERBOSE_CHR_LEVEL,
"#\tback from getData, found %llu valid points\n", valuesFound);
doAscii = operations & wigFetchAscii;
doBed = operations & wigFetchBed;
doStats = operations & wigFetchStats;
doNoOp = operations & wigFetchNoOp;
/* for timing purposes, allow the wigFetchNoOp to go through */
if (doNoOp)
doDataArray = doBed = doStats = doAscii = FALSE;
/* if ((something found) and (something to do)) */
if ((valuesFound > 0) && (doAscii || doBed || doStats || doNoOp))
{
struct wigAsciiData *wigAscii = NULL;
struct asciiDatum *asciiOut = NULL;
/* to address data[] in wigAsciiData */
dataArraySize = wds->array->winEnd - wds->array->winStart;
/* no bed constraint, then worst case ascii limit: dataArraySize */
if (0 == asciiDataSizeLimit)
asciiDataSizeLimit = dataArraySize;
if (verboseLevel() > VERBOSE_PER_VALUE_LEVEL)
dataArrayOut(wds, "stdout", FALSE, TRUE);
/* OK, ready to scan the bedArray in concert with the data
* array and pick out those values that are masked by the bed.
* The starting position will be the greater of the
* two different possible windows.
*/
if (doAscii)
{
AllocVar(wigAscii);
wigAscii->chrom = cloneString(wds->chrName);
wigAscii->span = 1; /* span information has been lost */
wigAscii->count = 0; /* will count up as values added */
wigAscii->dataRange = 0.0; /* to be determined */
setMaxAlloc((size_t)( HUGE_LIMIT *
(((sizeof(size_t)/4)*(sizeof(size_t)/4)*(sizeof(size_t)/4)))));
/* produces: size_t is 4 ~= 4 Gb
* size_t is 8 ~= 32 Gb
*/
verbose(VERBOSE_CHR_LEVEL,
"#\tworst case ascii array needLargeMem (%llu * %llu = %llu)\n",
(unsigned long long)sizeof(struct asciiDatum),
(unsigned long long)asciiDataSizeLimit,
(unsigned long long)(sizeof(struct asciiDatum) * asciiDataSizeLimit));
wigAscii->data = (struct asciiDatum *) needLargeMem((size_t)
(sizeof(struct asciiDatum) * asciiDataSizeLimit));
/* maximum area needed, may use less */
asciiOut = wigAscii->data; /* ptr to data area */
slAddHead(&wds->ascii,wigAscii);
}
chromPosition = max(bedStart, winStart);
boolPtr = bedArray + (chromPosition - bedStart);
fptr = wds->array->data + (chromPosition - winStart);
for ( ; (!maxReached) && (chromPosition < winEnd);
++chromPosition, ++boolPtr, ++fptr)
{
if (wds->maxOutput)
{
if (doAscii)
{
/* previous results to this fetch are wds->valuesMatched
* this result is currently at valuesMatched
*/
if (wds->maxOutput <=
(wds->valuesMatched + valuesMatched))
{
maxReached = TRUE;
break;
}
}
if (doBed)
{
/* previous results to this fetch are
* wds->totalBedElements, this result is currently
* at bedElCount. The -1 is because there is
* one more bed element to go upon exit from
* this loop.
*/
if ( (wds->totalBedElements + bedElCount) >=
(wds->maxOutput - 1) )
{
maxReached = TRUE;
break;
}
}
}
if (*boolPtr && (!isnan(*fptr)))
{
float value = *fptr;
++valuesMatched;
/* construct output listings here */
if (doAscii)
{
/* record limits when not also doing that
* for stats */
if (!doStats)
{
if (value < lowerLimit)
lowerLimit = value;
if (value > upperLimit)
upperLimit = value;
}
asciiOut->value = value;
asciiOut->chromStart = chromPosition;
if (wigAscii->count < asciiDataSizeLimit)
{
++asciiOut;
++wigAscii->count;
}
else
maxReached = TRUE;
}
if (doBed)
{
/* have we started a bed element yet ? */
if (0 == bedElEnd)
bedElEnd = bedElStart = chromPosition;
/* That will get it started right here */
/* as long as they are continuous, keep
* extending the end
*/
if (chromPosition == bedElEnd)
bedElEnd += 1; /* span information has been lost */
else
{ /* if one was collected, output it */
if (bedElEnd > bedElStart)
{
struct bed *bedEl;
bedEl = bedElement(wds->chrName,
bedElStart, bedElEnd, ++bedElCount);
slAddHead(&wds->bed, bedEl);
}
/* start a new element here */
bedElStart = chromPosition;
bedElEnd = bedElStart + 1; /* span = 1 */
}
} /* if (doBed) */
if (doStats)
{
/* record maximum data limits */
if (value < lowerLimit)
lowerLimit = value;
if (value > upperLimit)
upperLimit = value;
sumData += value;
sumSquares += value * value;
/* record maximum extents */
if ((chromStart < 0)||(chromStart > chromPosition))
chromStart = chromPosition;
if (chromEnd < (chromPosition + 1)) /* span = 1 */
chromEnd = chromPosition + 1; /* span = 1 */
++statsCount;
}
} /* if (*boolPtr && (!isnan(*fptr))) */
}
/* if we can save more than 100,000 data locations, move
* the results to a smaller area. Could be huge savings on
* very sparse result sets. This comes about because at
* the beginning we blindly allocated a full
* winEnd-winStart data array and we probably did not use
* all of that.
*/
if (doAscii && ((asciiDataSizeLimit - wigAscii->count) > 100000))
{
struct asciiDatum *smallerDataArea;
size_t newSize;
newSize = sizeof(struct asciiDatum) * wigAscii->count;
if (newSize > 0)
{
setMaxAlloc((size_t)( HUGE_LIMIT *
(((sizeof(size_t)/4)*(sizeof(size_t)/4)*(sizeof(size_t)/4)))));
/* produces: size_t is 4 ~= 4 Gb
* size_t is 8 ~= 32 Gb
*/
verbose(VERBOSE_CHR_LEVEL,
"#\tmoving to smaller ascii array needLargeMem( %llu * %llu = %llu)\n",
(unsigned long long)sizeof(struct asciiDatum),
(unsigned long long)wigAscii->count,
(unsigned long long)(sizeof(struct asciiDatum) * wigAscii->count));
smallerDataArea=(struct asciiDatum *)needLargeMem(newSize);
memcpy(smallerDataArea, wigAscii->data, newSize);
freeMem(wigAscii->data);
wigAscii->data = smallerDataArea;
}
else
{
freeMem(wigAscii->data);
wigAscii->data = NULL;
}
}
/* record dataRange for resolution accounting */
if (doAscii && wigAscii->count)
wigAscii->dataRange = (upperLimit - lowerLimit);
if (doBed) /* there may be one last element */
{
if (bedElEnd > bedElStart)
{
struct bed *bedEl;
bedEl = bedElement(wds->chrName,
bedElStart, bedElEnd, ++bedElCount);
slAddHead(&wds->bed, bedEl);
}
}
/* there are accumulated stats to complete */
if (doStats)
{
accumStats(wds, lowerLimit, upperLimit, sumData, sumSquares,
statsCount, chromStart, chromEnd);
if (wds->stats)
wds->stats->span = 1; /* viaBed reduces span to 1 */
resetStats(&lowerLimit, &upperLimit, &sumData, &sumSquares,
&statsCount, &chromStart, &chromEnd);
}
verbose(VERBOSE_CHR_LEVEL,
"#\tviaBed found: %llu valid data points\n", valuesMatched);
} /* if ((something found) and (something to do)) */
/* did they want the data array returned ? No, then release it */
if (!doDataArray)
wds->freeArray(wds);
/* we are certainly done with the bedArray */
bedFreeList(&filteredBed);
freeMem(bedArray);
wds->totalBedElements += bedElCount;
} /* for (chr = chromList; chr; chr = chr->next) */
/* restore these constraints we used here
*/
if (chromConstraint)
{
wds->setChromConstraint(wds, saveChrName);
freeMem(saveChrName);
}
else
{
freeMem(wds->chrName);
wds->chrName = NULL;
}
if (positionConstraints)
wds->setPositionConstraint(wds, saveWinStart, saveWinEnd);
else
wds->setPositionConstraint(wds, 0, 0);
/* The bedConstrained flag will provide a printout indication of
* what happened to the *Out() routines.
*/
wds->bedConstrained = TRUE; /* to signal the *Out() displays */
freeHashAndVals(&chromSizes);
} /* if (bedList && *bedList) */
wds->valuesMatched += valuesMatched;
return(valuesMatched);
} /* static unsigned long long getDataViaBed() */
static void sortResults(struct wiggleDataStream *wds)
/* sort any results that exist */
{
if (wds->bed)
slSort(&wds->bed, bedCmp);
if (wds->ascii)
slSort(&wds->ascii, asciiDataCmp);
if (wds->stats)
slSort(&wds->stats, statsDataCmp);
if (wds->array)
slSort(&wds->array, arrayDataCmp);
}
static int bedOut(struct wiggleDataStream *wds, char *fileName, boolean sort)
/* print to fileName the bed list */
{
int linesOut = 0;
FILE * fh;
fh = mustOpen(fileName, "w");
if (wds->bed)
{
struct bed *bedEl, *next;
outputIdentification(wds, fh);
showConstraints(wds, fh);
if (sort)
slSort(&wds->bed, bedCmp);
for (bedEl = wds->bed; bedEl; bedEl = next )
{
fprintf(fh,"%s\t%u\t%u\t%s\n", bedEl->chrom, bedEl->chromStart,
bedEl->chromEnd, bedEl->name);
next = bedEl->next;
++linesOut;
}
}
else
{
showConstraints(wds, fh);
fprintf(fh, "#\tbed: no data points found for bed format output (maxOutput: %llu)\n", wds->maxOutput);
}
carefulClose(&fh);
return (linesOut);
} /* static void bedOut() */
static void statsOut(struct wiggleDataStream *wds, char *db, char *fileName,
boolean sort, boolean htmlOut, boolean withHeader,
boolean leaveTableOpen)
/* print to fileName the statistics */
{
FILE * fh;
fh = mustOpen(fileName, "w");
if (wds->stats)
{
struct wiggleStats *stats, *next;
int itemsDisplayed = 0;
if (sort)
slSort(&wds->stats, statsDataCmp);
if (withHeader)
wigStatsHeader(wds, fh, htmlOut);
for (stats = wds->stats; stats; stats = next )
{
if (htmlOut)
{
long long chromSize = 0;
if (wds->winEnd)
chromSize = wds->winEnd - wds->winStart;
else
{
if (! wds->isFile)
chromSize = hChromSize(db, stats->chrom);
}
fprintf(fh,"| %s | \n", stats->chrom);
fprintf(fh,"\t %u | \n",
BASE_1(stats->chromStart)); /* display closed coords */
fprintf(fh,"\t %u | \n", stats->chromEnd);
fprintf(fh,"\t ");
printLongWithCommas(fh, (long long)stats->count);
fprintf(fh," | \n");
fprintf(fh,"\t %d | \n", stats->span);
fprintf(fh,"\t ");
printLongWithCommas(fh, (long long) stats->count*stats->span);
if (chromSize > 0)
fprintf(fh," (%.2f%%) | \n",
100.0*(double)(stats->count*stats->span)/(double)chromSize);
else
fprintf(fh,"\n");
fprintf(fh,"\t %g | \n", stats->lowerLimit);
fprintf(fh,"\t %g | \n", stats->lowerLimit+stats->dataRange);
fprintf(fh,"\t %g | \n", stats->dataRange);
fprintf(fh,"\t %g | \n", stats->mean);
fprintf(fh,"\t %g | \n", stats->variance);
fprintf(fh,"\t %g | \n", stats->stddev);
fprintf(fh,"
|---|
\n");
}
else
{
fprintf(fh,"%s", stats->chrom);
fprintf(fh,"\t%u", BASE_1(stats->chromStart));
/* display closed coords */
fprintf(fh,"\t%u", stats->chromEnd);
fprintf(fh,"\t%u", stats->count);
fprintf(fh,"\t%d", stats->span);
fprintf(fh,"\t%u", stats->count*stats->span);
fprintf(fh,"\t%g", stats->lowerLimit);
fprintf(fh,"\t%g", stats->lowerLimit+stats->dataRange);
fprintf(fh,"\t%g", stats->dataRange);
fprintf(fh,"\t%g", stats->mean);
fprintf(fh,"\t%g", stats->variance);
fprintf(fh,"\t%g", stats->stddev);
fprintf(fh,"\n");
}
++itemsDisplayed;
next = stats->next;
}
if (!itemsDisplayed)
{
if (htmlOut)
fprintf(fh,"| No data found matching this request |
|---|
\n");
else
fprintf(fh,"#\tNo data found matching this request\n");
}
if (!leaveTableOpen && withHeader && htmlOut)
fprintf(fh,"
|