ba9b4bffc83af21310d6525f54d82bd117854c04 max Wed May 15 16:33:39 2019 +0200 improving data updates docs for clinvar, no redmine, just noticed this while using the track diff --git src/hg/makeDb/trackDb/human/clinvar.html src/hg/makeDb/trackDb/human/clinvar.html index 88f7c84..74938c5 100644 --- src/hg/makeDb/trackDb/human/clinvar.html +++ src/hg/makeDb/trackDb/human/clinvar.html @@ -50,55 +50,57 @@ <B><font color="blue">blue for gain</font></b>. </p> <p> Entries in the ClinVar short variants track are shaded by clinical annotation: <b><font color="red">red for pathogenic</font></b>, <B><font color="#888">dark grey for uncertain significance or not provided</font></b> and <B><font color="green">green for benign</font></b>. </p> <p> The score of the variants is the number of "stars" in ClinVar. On the track configuration page (above), you can filter the track to show only variants with more than a certain number of stars. For more information on the star rating, see the <a href="https://www.ncbi.nlm.nih.gov/clinvar/docs/review_status/" target="_blank">ClinVar documentation</a>. </p> +<h2>Data updates</h2> +<p>ClinVar publishes a new release once per month and this track is updated automatically 5-6 days +later. You can find the previous versions of the track organized by month on our +downloads server in the +<a href="http://hgdownload.soe.ucsc.edu/goldenPath/hg19/archive/clinvar/" target="_blank">archive</a> +directory. To access one of these previous versions, paste the URL to one of +the older files into our "Custom tracks" box.</p> <H2>Data access</H2> <p> The raw data can be explored interactively with the <a href="../cgi-bin/hgTables">Table Browser</a> or the <a href="../cgi-bin/hgIntegrator">Data Integrator</a>. <p> For automated download and analysis, the genome annotation is stored in a bigBed file that can be downloaded from <a href="http://hgdownload.soe.ucsc.edu/gbdb/$db/bbi/" target="_blank">our download server</a>. The files for this track are called <tt>clinVarMain.bb</tt> and <tt>clinVarCnv.bb</tt>. Individual regions or the whole genome annotation can be obtained using our tool <tt>bigBedToBed</tt> which can be compiled from the source code or downloaded as a precompiled binary for your system. Instructions for downloading source code and binaries can be found <a href="http://hgdownload.soe.ucsc.edu/downloads.html#utilities_downloads">here</a>. The tool can also be used to obtain only features within a given range, e.g. <tt>bigBedToBed http://hgdownload.soe.ucsc.edu/gbdb/hg19/bbi/clinvar/clinvarMain.bb -chrom=chr21 -start=0 -end=100000000 stdout</tt></p> </p> -<p> -You can find previous versions of the ClinVar tracks organized by month on our -download server <a href="http://hgdownload.soe.ucsc.edu/goldenPath/hg19/archive/clinvar/" target="_blank">here</a>. -</p> - <h2>Methods</h2> <p> ClinVar files were reformatted at UCSC to the <a href="../goldenPath/help/bigBed.html">bigBed</a> format. The data is updated every month, one week after the ClinVar release date. The program that performs the update is available on <a href="https://github.com/ucscGenomeBrowser/kent/blob/master/src/hg/utils/otto/clinvar/clinVarToBed" target="_blank">Github</a>. </p> <h2>Credits</h2> <p> Thanks to NCBI for making the ClinVar data available on their FTP site as a tab-separated file. </p>