d2a02f56a0e84d51213d44955b694ce7daace230 jnavarr5 Fri May 31 11:41:50 2019 -0700 Updating redirected links for hg18, uiLinks cronjob. diff --git src/hg/makeDb/trackDb/human/acescan.html src/hg/makeDb/trackDb/human/acescan.html index 4b2056e..71bdc1d 100644 --- src/hg/makeDb/trackDb/human/acescan.html +++ src/hg/makeDb/trackDb/human/acescan.html @@ -1,52 +1,52 @@ <H2>Description</H2> <P> This track identifies predicted Alternative Conserved Exons (human-mouse conservation), as predicted by ACEScan. These are exons that are present in some transcripts, but skipped by alternative splicing in other transcripts in both human and mouse. Alternate use of skipped exons has important consequences during gene expression and in disease. <H2>Methods</H2> <P> Putative alternative conserved exons on mRNAs were identified using a machine-learning algorithm, Regularized Least-Squares Classification. Characteristics of known exons that have been skipped in both human and mouse mRNAs were determined by considering factors such as exon and intron length, splice-site strength, sequence conservation, and region-specific oligonucleotide composition. </P> <P>A training set was made by comparing known exons that are skipped in some transcripts to exons never skipped. These characteristics were then applied to the whole genome to predict skipped exons in other transcripts. This track displays exons with positive ACEScan scores.</P> <P>For further details of the method used to generate this annotation, please refer to Yeo <I>et al.</I> (2005). <H2>Credits</H2> <P> Thanks to Gene Yeo at the Crick-Jacobs Center, Salk Institute and Christopher Burge, MIT, for providing this annotation. For additional information on ACEscan predictions please contact geneyeo@salk.edu <!-- above address is geneyeo at salk dot edu --> or cburge@mit.edu. <!-- above address is cburge at mit dot edu. --> <H2>References</H2> <P> Yeo GW, Van Nostrand E, Holste D, Poggio T, Burge CB (2005), -<A HREF = "http://www.pnas.org/cgi/content/full/102/8/2850" +<A HREF = "https://www.pnas.org/content/102/8/2850" TARGET = _BLANK> Identification and analysis of alternative splicing events conserved in human and mouse.</A> <I>Proc Natl Acad Sci U S A.</I> 2005 Feb 22;102(8):2850-5. </P>