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jnavarr5
  Fri May 31 11:41:50 2019 -0700
Updating redirected links for hg18, uiLinks cronjob.

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 <H2>Description</H2>
 <P>
 This track shows single nucleotide polymorphisms (SNPs) used in a
 genome-wide scan for signals of positive selection in the human
 lineage since divergence from the Neandertal lineage.</P>
 <P>
 SNP labels represent the ancestral (A) or derived (D) status,
 determined by comparison with the chimpanzee reference genome,
 of alleles in the human reference assembly, five modern human
 genomes of diverse ancestry (see the 
 <A HREF="/cgi-bin/hgTrackUi?&c=chr1&g=ntModernHumans">Modern Human Seq</A> 
 track), and Neandertals.  
 The first six characters of an item name show the status of the allele
 (A, D or _ if not known)
 in six genomes: human reference, San, Yoruba, Han, Papuan, and French, in that
 order. These characters are followed by a colon, the number of derived alleles
 found in Neandertals, a comma and the number of ancestral alleles found in
 Neandertals.  
 For example, a SNP labeled AAADAA:0D,2A has the ancestral allele in
 the reference human genome and in all of the modern human genomes
 except Han.  Among Neandertals, two instances of the ancestral allele 
 were found, but no instances of the derived allele.  
 </P>
 <P>
 SNPs are colored <B><FONT COLOR = "red">red</FONT></B> when at least four of the six modern human
 genomes are derived while all observed Neandertal alleles are
 ancestral.  An overrepresentation of such SNPs in a region would 
 imply that the region had undergone positive selection in the 
 modern human lineage since divergence from Neandertals; the 
 <A HREF="/cgi-bin/hgTrackUi?&c=chr1&g=ntSssZScorePMVar">Sel Swp Scan 
 (S)</A> track displays a signal calculated from these SNPs, and the 
 <A HREF="/cgi-bin/hgTrackUi?&c=chr1&g=ntSssTop5p">5% Lowest S</A>
 track contains the regions in which the signal most strongly indicates selective
 pressure on the modern human lineage.
 </P>
 
 <H2>Display Conventions and Configuration</H2>
 <P>
 <B><FONT COLOR = "red">Red</FONT></B>
 SNPs are those where at least four of the six modern human
 genomes are derived while all observed Neandertal alleles are
 ancestral. All other SNPs are <B>black</B>.
 </P>
 
 <H2>Methods</H2>
 <P>
 For the purposes of this analysis, SNPs were defined as single-base
 sites that are polymorphic among 5 modern human genomes of diverse
 ancestry (see the 
 <A HREF="/cgi-bin/hgTrackUi?&c=chr1&g=ntModernHumans">Modern Human Seq</A> 
 track) plus the human reference
 genome.  SNPs at CpG sites were excluded because of the higher
 mutation rate at CpG sites.  
 Ancestral or derived state was determined by comparison with the 
 chimpanzee genome.  
 </P>
 
 <H2>Credits</H2>
 <P>
 This track was produced at UCSC using data generated by
 <A HREF="mailto:&#101;&#100;&#64;&#115;&#111;e.&#117;&#99;s&#99;.&#101;&#100;&#117;"
 title="&#101;&#100;&#64;&#115;&#111;e.&#117;&#99;s&#99;.&#101;&#100;&#117;" rel="nofollow"
 TARGET = _BLANK>Ed Green</A>.
 </P>
 
 <H2>Reference</H2>
 <p>
 Green RE, Krause J, Briggs AW, Maricic T, Stenzel U, Kircher M, Patterson N, Li H, Zhai W, Fritz MH
 <em>et al</em>.
-<a href="http://science.sciencemag.org/content/328/5979/710" target="_blank">
+<a href="https://science.sciencemag.org/content/328/5979/710" target="_blank">
 A draft sequence of the Neandertal genome</a>.
 <em>Science</em>. 2010 May 7;328(5979):710-22.
 PMID: <a href="https://www.ncbi.nlm.nih.gov/pubmed/20448178" target="_blank">20448178</a>
 </p>