d2a02f56a0e84d51213d44955b694ce7daace230
jnavarr5
  Fri May 31 11:41:50 2019 -0700
Updating redirected links for hg18, uiLinks cronjob.

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 <H2>Description</H2>
 
 <!--#insert file="omimDescriptionText.html"-->
 
 <P>
 This track shows the <B>cytogenetic locations</B> of phenotype entries in the Online Mendelian
-Inheritance in Man (<A HREF="http://www.omim.org/" TARGET=_blank>OMIM</A>) database for which
+Inheritance in Man (<A HREF="https://www.omim.org/" TARGET=_blank>OMIM</A>) database for which
 the gene is unknown.
 </P>
 
 <H2>Display Conventions and Configuration</H2>
 
 <P>Cytogenetic locations of OMIM entries are displayed as solid
 blocks.  The entries are colored according to the OMIM phenotype map key of associated disorders:
 
 <UL>
 <LI><B><FONT COLOR="#AAC4AA">Lighter Green</FONT></B> for phenotype map key 1 OMIM records
 -  the disorder has been placed on the map based on its association with
 a gene, but the underlying defect is not known.
 <LI><B><FONT COLOR="#669666">Light Green</FONT></B> for phenotype map key 2 OMIM records
 - the disorder has been placed on the map by linkage; no mutation has
 been found.
 <LI><B><FONT COLOR="#005000">Dark Green</FONT></B> for phenotype map key 3 OMIM records
 - the molecular basis for the disorder is known; a mutation has been
 found in the gene.
 <LI><B><FONT COLOR="#69329B">Purple</FONT></B> for phenotype map key 4 OMIM records
 - a contiguous gene deletion or duplication syndrome; multiple genes
 are deleted or duplicated causing the phenotype.
 </UL>
 <P>Gene symbols and disease information, when available, are displayed on the details pages.
 </P>
 <P>The descriptions of OMIM entries are shown on the main browser display when Full display
 mode is chosen.  In Pack mode, the descriptions are shown when mousing over each entry. Items
 displayed can be filtered according to phenotype map key on the track controls page.
 </P>
 
 <H2>Methods</H2>
 <P>
 This track was constructed as follows: 
 <UL>
 <LI>The data file <TT>genemap.txt</TT> from OMIM was loaded into the MySQL table
 <TT>omimGeneMap</TT>.
 <LI>Entries in <TT>genemap.txt</TT> having disorder info were parsed and loaded into the
 <TT>omimPhenotype</TT> table. The phenotype map keys (the numbers (1)(2)(3)(4) from the
 disorder columns) were placed into a separate field.
 <LI>The cytogenetic location data (from the location column in <TT>omimGeneMap</TT>) were
 parsed and converted into genomic start and end positions based on the <TT>cytoBand</TT> table.
 These genomic positions, together with the corresponding OMIM IDs, were loaded into the
 <TT>omimLocation</TT> table.
 <LI>All entries with no associated phenotype map key and all OMIM gene entries as reported in the
 &quot;OMIM Genes&quot; track were then excluded from the <TT>omimLocation</TT> table.
 </UL>
 
 <H2>Credits</H2>
 <P>
 Thanks to OMIM and NCBI for the use of their data. This track was constructed by Fan Hsu,
 Robert Kuhn, and Brooke Rhead of the UCSC Genome Bioinformatics Group.</P>
 
 <H2>References</H2>
 <p>
 Amberger J, Bocchini CA, Scott AF, Hamosh A.
 <a href="https://academic.oup.com/nar/article/37/suppl_1/D793/1003813" target="_blank">
 McKusick's Online Mendelian Inheritance in Man (OMIM)</a>.
 <em>Nucleic Acids Res</em>. 2009 Jan;37(Database issue):D793-6.
 PMID: <a href="https://www.ncbi.nlm.nih.gov/pubmed/18842627" target="_blank">18842627</a>; PMC: <a
 href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686440/" target="_blank">PMC2686440</a>
 </p>
 
 <p>
 Hamosh A, Scott AF, Amberger JS, Bocchini CA, McKusick VA.
 <a href="https://academic.oup.com/nar/article/33/suppl_1/D514/2505259" target="_blank">
 Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic
 disorders</a>.
 <em>Nucleic Acids Res</em>. 2005 Jan 1;33(Database issue):D514-7.
 PMID: <a href="https://www.ncbi.nlm.nih.gov/pubmed/15608251" target="_blank">15608251</a>; PMC: <a
 href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC539987/" target="_blank">PMC539987</a>
 </p>