We are pleased to announce two new ENCODE 3 transcription factor binding site tracks for human (GRCh37/hg19, GRCh38/hg38) assemblies. These tracks show regions of transcription factor binding derived from a large collection of ChIP-seq experiments performed by the ENCODE project between February 2011 and November 2018.
+The following two sessions express where the CTCF Binding factor binds to the MYC Proto-Oncogene
+across more than 100 cell types. CTCF is a transcription factor identified as a repressor of MYC
+shown to cause cell growth inhibition (Qi et al., 2002).
+
The ENCODE TF ChIP-seq data were processed using the
-ENCODE Transcription Factor ChIP-seq Processing
-Pipeline to generate peaks of TF binding. Peaks from 1264 experiments (1256 in hg38) representing
-338 transcription factors (340 in hg38) in 130 cell types (129 in hg38) were compiled in order to
-generate these two tracks. The peaks were grouped together to produce a summary display showing
-occupancy regions for each factor, seen here in the TF ChIP Clusters tracks:
-hg19,
-hg38
-The underlying ChIP-seq peak data are available from the ENCODE 3 TF ChIP Peaks tracks:
-hg19,
-hg38
+ENCODE Transcription Factor ChIP-seq Processing Pipeline to generate peaks of TF binding.
+Peaks from 1264 experiments (1256 in hg38) representing 338 transcription factors (340 in hg38) in
+130 cell types (129 in hg38) were compiled in order to generate these two tracks.
+
Thanks to the ENCODE Consortium, the ENCODE ChIP-seq production laboratories, and the ENCODE Data Coordination Center for generating and processing the TF ChIP-seq datasets used here. The ENCODE accession numbers of the constituent datasets are available from the peak details page. Special thanks to Henry Pratt, Jill Moore, Michael Purcaro, and Zhiping Weng, PI, at the ENCODE Data Analysis Center (ZLab at UMass Medical Center) for providing the peak datasets, metadata, and guidance developing this track. Thanks to Kate Rosenbloom and Conner Powell of the UCSC Genome Browser group for their work in creating and releasing these tracks.