451a83e7cfa9ee06c2d32d6fc7c2bbcfbe0aed84 jnavarr5 Wed Aug 21 09:54:49 2019 -0700 Capitalizing the titles on the history page, refs #20314 diff --git src/hg/htdocs/goldenPath/history.html src/hg/htdocs/goldenPath/history.html index cc2cf76..66ee645 100755 --- src/hg/htdocs/goldenPath/history.html +++ src/hg/htdocs/goldenPath/history.html @@ -1,45 +1,45 @@ <!DOCTYPE html> <!--#set var="TITLE" value="Genome Browser History" --> <!--#set var="ROOT" value=".." --> <!-- Relative paths to support mirror sites with non-standard GB docs install --> <!--#include virtual="$ROOT/inc/gbPageStart.html" --> <h1>UCSC Genome Browser Project History</h1> <h2>Table of Contents</h2> <ul> - <li><a href="#overview">Genome Browser overview</a></li> + <li><a href="#overview">Genome Browser Overview</a></li> <li><a href="#race">Human Genome Project Race</a></li> <ul class="gbsNoBullet"> <li><a href="#celera">New challenger, Celera Genomics</a></li> <li><a href="#push">Push to the Finish Line</a></li> </ul> <li><a href="#ENCODE">The ENCODE Project</a></li> <ul class="gbsNoBullet"> - <li><a href="#ucsc">UC Santa Cruz's role</a></li> + <li><a href="#ucsc">UC Santa Cruz's Role</a></li> </ul> <li><a href="#primer">UCSC Genome Research Primer</a></li> <ul class="gbsNoBullet"> <li><a href="#comparative">Comparative Genomics</a></li> <li><a href="#health">Possibilities for Health</a></li> </ul> </ul> <a name="overview"></a> -<h2>Genome Browser overview</h2> +<h2>Genome Browser Overview</h2> <p> The UCSC Genome Browser is a web-based tool serving as a multi-powered microscope that allows researchers to view all 23 chromosomes of the human genome at any scale from a full chromosome down to an individual nucleotide. The browser integrates the work of countless scientists in laboratories worldwide, including work generated at UCSC, in an interactive, graphical display.</p> <p> Zoomed out, the coarse-level view shows early chromosome maps as determined by electron microscopy, then the browser drills down to levels of increasing detail, focusing first on chromosome bands, then on gene clusters (showing known genes-mostly those linked to diseases), then single genes, then the components of genes, and finally on the nucleotides-the As, Cs, Gs, and Ts that make up the genome alphabet. Not only does the browser show the genome sequence, but it also delineates known areas of the genome and offers supplementary information about the genes-in effect, providing the word breaks and punctuation.</p> <p> Genome sequences are difficult to read because they consist of letter strings with no breaks or @@ -209,31 +209,31 @@ <a href="https://www.encodeproject.org/" target="_blank">ENCyclopedia Of DNA Elements (ENCODE) project</a>, an international endeavor to generate a comprehensive parts list of all the functional components in the human genome.</p> <p> ENCODE is a scientific reconnaissance mission aimed at discovering all regions of the human genome crucial to biological function. Before ENCODE, scientists focused on finding the genes, or protein-coding regions in DNA sequences, but these account for only about 1.5% of the genetic material of humans and other mammals. Non-coding regions of the genome have important functions, and the ENCODE project is developing a comprehensive "parts list" by identifying and precisely locating all functional elements in the human genome. This project, sponsored by the <a href="https://www.genome.gov/" target="_blank">National Human Genome Research Institute (NHGRI)</a>, involves an international consortium of scientists from government, industry, and academia.</p> <a name="ucsc"></a> -<h3>UC Santa Cruz's role</h3> +<h3>UC Santa Cruz's Role</h3> <p> UC Santa Cruz developed and ran the data coordination center for the ENCODE project from its inception in 2003 through the end of the first production phase in 2012. During that time, the UCSC Genome Browser group directed by Jim Kent with technical management by Kate Rosenbloom provided the database and web interface for all sequence-related data for the ENCODE project. This included integrating the data into the UCSC Human Genome Browser (where it continues to reside) on specialized tracks, and providing further in-depth information on detail pages. UC Santa Cruz also developed, performed, and presented computational and comparative analyses to glean further genomic and functional information from the collective data.</p> <p> UC Santa Cruz worked closely with labs producing data for the ENCODE project and with data analysis groups to define data and metadata reporting standards for a broad range of genomics assays. They implemented data submission and validation pipelines, created and maintained the encodeproject.org website, developed user access tools for ENCODE data, exported all ENCODE data to repositories at the National Center for Biotechnology Information (NCBI), and provided outreach and tutorial support