0a1cd358605c0737979f9bc735ab6bfb67196045 jnavarr5 Fri Sep 6 12:44:30 2019 -0700 Restructuring an introductory paragraph for the history.html page, refs #20314 diff --git src/hg/htdocs/goldenPath/history.html src/hg/htdocs/goldenPath/history.html index d6186c7..01af301 100755 --- src/hg/htdocs/goldenPath/history.html +++ src/hg/htdocs/goldenPath/history.html @@ -22,37 +22,38 @@ <li><a href="#primer">UCSC Genome Research Primer</a></li> <ul class="gbsNoBullet"> <li><a href="#comparative">Comparative Genomics</a></li> <li><a href="#health">Possibilities for Health</a></li> </ul> </ul> <a name="overview"></a> <h2>Genome Browser Overview</h2> <p> The UCSC Genome Browser is a web-based tool serving as a multi-powered microscope that allows researchers to view all 23 chromosomes of the human genome at any scale from a full chromosome down to an individual nucleotide. The browser integrates the work of countless scientists in laboratories worldwide, including work generated at UCSC, in an interactive, graphical display.</p> <p> -Zoomed out, the coarse-level view shows early chromosome maps as determined by electron microscopy, -then the browser drills down to levels of increasing detail, focusing first on chromosome bands, -then on gene clusters (showing known genes-mostly those linked to diseases), then single genes, then -the components of genes, and finally on the nucleotides-the As, Cs, Gs, and Ts that make up the -genome alphabet. Not only does the browser show the genome sequence, but it also delineates known -areas of the genome and offers supplementary information about the genes-in effect, providing the -word breaks and punctuation.</p> +Zoomed out, the coarse-level view of the genome shows early chromosome maps as determined by +electron microscopy, then the browser drills down to levels of increasing detail, focusing first on +chromosome bands. The next level detail zooms in on gene clusters, showing known and predicted genes +near one another on the chromosome. Zooming in further to view a single gene shows the components of +genes, the introns and exons. Finally, the browser allows researchers to view the nucleotides-the +As, Cs, Gs, and Ts that make up the genome alphabet. Not only does the browser show the genome +sequence, but it also delineates known areas of the genome and offers supplementary information +about the genes-in effect, providing the word breaks and punctuation.</p> <p> Genome sequences are difficult to read because they consist of letter strings with no breaks or punctuation. The example below contains 7 different letters (genomes contain only 4). Can you understand what it is saying? (Line borrowed from the movie, <em><a href = "https://en.wikipedia.org/wiki/Charly" target = _blank>Charly</a></em>.)</p> <pre> THATTHATISISTHATTHATISNOTISNOTISTHATITITIS</pre> <p> With word breaks and punctuation, it starts to make sense:</p> <pre> THAT THAT IS, IS. THAT THAT IS NOT, IS NOT. IS THAT IT? IT IS!</pre> <p> The UCSC Genome Browser group played a pivotal role in bringing this extraordinary life script into the light of science. The browser presents both experimentally validated and computer-predicted genes along with dozens of lines of evidence that help scientists recognize the key features of