c5e232d6f6bcec33a0531b083848a3c5b9e70fa9 jnavarr5 Fri Sep 6 14:08:39 2019 -0700 Adding a note that we surpassed 200 assemblies in 2018. Ann provided the comment, but the date and number still need to be fact checked. refs #20314 diff --git src/hg/htdocs/goldenPath/history.html src/hg/htdocs/goldenPath/history.html index 4ee5ac3..57aa222 100755 --- src/hg/htdocs/goldenPath/history.html +++ src/hg/htdocs/goldenPath/history.html @@ -283,35 +283,35 @@ Times article: "Now: the rest of the genome"</a></li> <li> <a href="https://www.genome.gov/11009066/" target="_blank">NHGRI announcement of the ENCODE Project</a></li> </ul> <a name="primer"></a> <h2>UCSC Genome Research Primer</h2> <a name="comparative"></a> <h3>Comparative Genomics</h3> <p> Besides developing, supporting, and continuing to improve the genome browser, the UCSC Genome Browser group conducts research into the functional elements of the human genome that have evolved under natural selection. Since the first assembly of the human genome, a growing number of species -have been added to the UCSC Genome Browser, including roundworm, -pufferfish, chicken, mouse, and chimpanzee. -Interspecies alignments allow researchers to compare human genes to similar genes in other species. -The UCSC Genome Browser allows rapid comparisons between species, which can lead to many different -types of new discoveries:</p> +have been added to the UCSC Genome Browser, including roundworm, pufferfish, chicken, mouse, and +chimpanzee. In 2018, the UCSC Genome Browser surpassed 200 assemblies for the various species hosted +on the browser. Interspecies alignments allow researchers to compare human genes to similar genes +in other species. The UCSC Genome Browser allows rapid comparisons between species, which can lead +to many different types of new discoveries:</p> <ul> <li> New gene discoveries can result from searching the human genome for sequences that match those with known functions in other organisms. The molecular genetics behind disease development and progression in model organisms can be leveraged to discover potential disease-related genes in humans, moving us closer to diagnostic advances and targeted treatments.</li> <li> We can reconstruct the evolutionary history of the human genome by identifying the origins of interspecies differences and of short segments in the human genome that have been extremely well-conserved over millions of years of evolution.</li> <li> By searching for the highly conserved segments in the human genome—those that are unchanged from like segments in the genomes of other organisms—we can begin to understand the essential elements of the blueprint for life. Researchers believe that these highly conserved elements must be essential to function; there has been too much time for the sequences to