+We are pleased to announce the release of a patch to the hg19 assembly that will introduce a new +mitochondrial sequence, chrMT, to the assembly. We used GenBank sequence NC_001807 for chrM in hg19 and +earlier, but the sequence preferred by the community is the revised Cambridge Reference Sequence +(rCRS), NC_012920. The +new chrMT is the rCRS, NC_012920. Patch sequences from +GRCh37.p13 have +also been added to hg19.
++More information on how patch sequences are incorporated can be found on the +Patching up the Genome blog post. +The blog post contains details about the new +/latest download directory on the downloads server. With the addition of new +sequences to hg19, we can expect to see BLAT return more matches to the genome.
++Also, with these patches, the hg19 genome is not optimal anymore for aligners. So we added an +"analysis set" version of the hg19 genome fasta file to our +bigZips +directory, and indexes for BWA, Bowtie2, and Hisat2.
++We would like to thank the Genome Research Consortium for creating the patches to hg19. We would +also like to thank Angie Hinrichs and Jairo Navarro at UCSC for implementing and testing the latest +patch to hg19.
We are pleased to announce a new track, RefSeq Select+MANE, for the GRCh37/hg19 and GRCh38/hg38 human assemblies. This track is a combination of NCBI transcripts with the RefSeq Select tag, as well as transcripts with the MANE Select tag. The result is a track with a single representative transcript for every protein-coding gene. The track can be found as part of the NCBI RefSeq composite track.
RefSeq Select transcripts are chosen by an NCBI pipeline to be representative of every protein-coding gene. As part of the