01850216d9f1ce7c891126d4ec846d722d76d9a7
abenetpa
  Wed Oct 14 11:52:04 2020 -0700
added sentence to desc page refs #26351

diff --git src/hg/makeDb/trackDb/human/covidHgeMuts.html src/hg/makeDb/trackDb/human/covidHgeMuts.html
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 <h2>Description</h2>
 <p>
-This track shows variants associated with monogenic congenital defects of immunity to SARS-CoV-2, 
+This track shows variants associated with monogenic congenital defects of immunity to <b>SARS-CoV-2</b>, 
 with incomplete or complete penetrance from the <a target=_blank 
 href="https://www.covidhge.com/">COVID Human Genetic Effort</a>. This international consortium aims 
 to detect rare or common monogenic inborn immunity errors (IEI) underlying severe forms of COVID-19 
 in previously healthy individuals, as well as rare or common monogenic variations that make certain 
 individuals resistant to the infection by SARS-CoV2 itself despite repeated exposure.
 </p>
 
 <p>
-Rare variants were predicted to be loss-of-function (LOF) at 13 human loci known to govern 
+The major feature of the small set of  variants in this track is that they are functionally tested 
+to be <b>deleterious</b> and genetically tested to be <b>disease-causing</b>. Specifically, 
+rare variants were predicted to be loss-of-function (LOF) at 13 human loci known to govern 
 TLR3- and IRF7-dependent type I interferon (IFN) immunity to influenza virus in patients with 
 life-threatening COVID-19 pneumonia, relative to subjects with asymptomatic or benign infection. 
 These genetic defects display incomplete penetrance for influenza respiratory distress and only 
 manifested clinically upon infection with the more virulent SARS-CoV-2.
 </p>
  
 <h2>Display Conventions</h2>
 
 
 
 <h2>Methods</h2>
 <p>
 Variant calls in 12 autosomal IFN-related genes from whole exome or genome data with a MAF lower 
 than 0.001 (gnomAD v2.1.1) and experimental demonstration of loss-of-function (LOF) were considered 
 for statistical analysis. Proportion of individuals carrying at least one pLOF variant was compared