3f4772e689c620fa0db33a2522e362cdcc216047 braney Sat Oct 17 07:24:30 2020 -0700 almost done with the clinvar submissions track! diff --git src/hg/hgc/clinvarSubLolly.c src/hg/hgc/clinvarSubLolly.c index 3049faf..31c8ca7 100644 --- src/hg/hgc/clinvarSubLolly.c +++ src/hg/hgc/clinvarSubLolly.c @@ -1,100 +1,115 @@ #include "common.h" #include "wiggle.h" #include "cart.h" #include "hgc.h" #include "hCommon.h" #include "hgColors.h" #include "bigBed.h" #include "hui.h" #include "subText.h" #include "trackHub.h" #include "clinvarSubLolly.h" - char *statusByScore[] = { "Other", "Benign", "Likely Benign", "Uncertain significance", "Likely pathogenic", "Pathogenic", }; void printSubmissions(struct trackDb *tdb, char *chrom, int start, int end, unsigned wantScore, int numSubs, boolean not) +/* Print out all the submissions at this position that match the + * desired score (ie. clinical status). + * If "not" is true, then print out all submissions that do NOT match score. + * We're grabbing these records out of a second bigBed that's referenced by + * "xrefDataUrl" in the trackDb. + */ { -char *xrefTrack = trackDbSetting(tdb, "xrefTrack"); -struct trackDb *mainTdb = hashFindVal(trackHash, xrefTrack); -char *mainBigBedFile = trackDbSetting(mainTdb, "bigDataUrl"); -struct bbiFile *bbi = bigBedFileOpen(mainBigBedFile); +char *xrefDataUrl = trackDbSetting(tdb, "xrefDataUrl"); +struct bbiFile *bbi = bigBedFileOpen(xrefDataUrl); +struct asObject *as = bigBedAsOrDefault(bbi); struct lm *lm = lmInit(0); struct bigBedInterval *bbList = bigBedIntervalQuery(bbi, chrom, start, end, 0, lm); int count; if (not) count = slCount(bbList) - numSubs; else count = numSubs; +// nothing to print if (count == 0) return; if (!not) printf("<BR><B>There are %d submissions at this position with clinical significance '%s'.</B><BR>\n", count, statusByScore[wantScore]); else - printf("<BR><B>There are %d submissions at this position with other clinical significance.</B><BR>\n", count); + printf("<BR><B>There are %d submissions at this position with some other clinical significance.</B><BR>\n", count); +// Step through intervals at the position to find ones that match the score we're looking for struct bigBedInterval *bb; for (bb = bbList; bb != NULL; bb = bb->next) { char *fields[bbi->fieldCount]; int restCount = chopTabs(cloneString(bb->rest), fields); int score = atoi(fields[1]); if (not ^ (score != wantScore)) continue; int restBedFields = 6; char **extraFields = (fields + restBedFields); int extraFieldCount = restCount - restBedFields; - extraFieldsPrint(mainTdb,NULL,extraFields, extraFieldCount); + extraFieldsPrintAs(tdb,NULL,extraFields, extraFieldCount, as); } printf("<BR>"); } void doClinvarSubLolly(struct trackDb *tdb, char *item) /* Put up page for clinvarSubLolly track. */ { genericHeader(tdb, NULL); struct sqlConnection *conn = NULL; if (!trackHubDatabase(database)) conn = hAllocConnTrack(database, tdb); int start = cartInt(cart, "o"); int end = cartInt(cart, "t"); char *chrom = cartString(cart, "c"); char *fileName = bbiNameFromSettingOrTable(tdb, conn, tdb->table); struct bbiFile *bbi = bigBedFileOpen(fileName); struct lm *lm = lmInit(0); struct bigBedInterval *bbList = bigBedIntervalQuery(bbi, chrom, start, end, 0, lm); struct bigBedInterval *bb; char *fields[bbi->fieldCount]; for (bb = bbList; bb != NULL; bb = bb->next) { if (!(bb->start == start && bb->end == end)) continue; + + // our names are unique char *name = cloneFirstWordByDelimiterNoSkip(bb->rest, '\t'); boolean match = (isEmpty(name) && isEmpty(item)) || sameOk(name, item); if (!match) continue; + char startBuf[16], endBuf[16]; bigBedIntervalToRow(bb, chrom, startBuf, endBuf, fields, bbi->fieldCount); int numSubs = chopString(fields[12], ",", NULL, 0); printPos(chrom, bb->start, bb->end, NULL, FALSE, name); + // print all the submissions that match the clinical significance of the + // bead that the user clicked on. printSubmissions(tdb, chrom, start, end, atoi(fields[4]), numSubs, FALSE); + + // no print the ones with a different clinical status printSubmissions(tdb, chrom, start, end, atoi(fields[4]), numSubs, TRUE); + + // we found what we wanted break; } }