Only eight genes and few variants are contained in this track. Use the links in the table to browse the gene of interest:
| Gene Name | Human GRCh37/hg19 Assembly | Human GRCh38/hg38 Assembly | ||
|---|---|---|---|---|
| TLR3 | -+ | chr4:186990309-187006252 | -+ | chr4:186069152-186088069 |
| IRF7 | -+ | chr11:612555-615999 | -+ | chr11:612591-615970 |
| UNC93B1 | -+ | chr11:67758575-67771593 | -+ | chr11:67991100-68004097 |
| TBK1 | -+ | chr12:64845840-64895899 | -+ | chr12:64452120-64502114 |
| TICAM1 | -+ | chr19:4815936-4831754 | -+ | chr19:4815932-4831704 |
| IRF3 | -+ | chr19:50162826-50169132 | -+ | chr19:49659570-49665875 |
| IFNAR1 | -+ | chr21:34697214-34732128 | -+ | chr21:33324970-33359864 |
| IFNAR2 | -+ | chr21:34602231-34636820 | -+ | chr21:33229974-33264525 |
This track uses variant calls in autosomal IFN-related genes from whole exome and genome data with a MAF lower than 0.001 (gnomAD v2.1.1) and experimental demonstration of loss-of-function. The patient population studied consisted of 659 patients with life-threatening COVID-19 pneumonia relative to 534 subjects with asymptomatic or benign infection of varying ethnicities. Variants underlying autosomal-recessive or autosomal-dominant deficiencies were identified in 23 patients (3.5%) 17 to 77 years of age. The proportion of individuals carrying at least one variant was compared between severe cases and control cases by means of logistic regression with the likelihood ratio test. Principal Component Analysis (PCA) was conducted with Plink v1.9 software on whole exome and