The major feature of the small set of variants in this track is that they are functionally tested to be deleterious and genetically tested to be disease-causing. Specifically, rare variants were predicted to be loss-of-function (LOF) at 13 human loci known to govern TLR3- and IRF7-dependent type I interferon (IFN) immunity to influenza virus in patients with life-threatening COVID-19 pneumonia, relative to subjects with asymptomatic or benign infection. These genetic defects display incomplete penetrance for influenza respiratory distress and only manifested clinically upon infection with the more virulent SARS-CoV-2.
-Unlike a regular genome browser track, the COVID-19 Immunity Variants track displays all -affected genes in multi-region view, -showing the variants within the coordinates of the gene, but hiding all the intergenic bases. To -return to the default Genome Browser view, click on the "-" button next to the "region" box. -
-Only eight genes and few variants are contained in this track. Use the links in the table to browse the gene of interest:
| Gene Name | Human GRCh37/hg19 Assembly | Human GRCh38/hg38 Assembly |
|---|---|---|
| TLR3 | chr4:186990309-187006252 |