Single nucleotide variants (SNV): For SNVs, at every
genome position, there are three values per position, one for every possible
nucleotide mutation. The fourth value, "no mutation", e.g. A to A, is always
set to zero.
When using this track, please zoom in until you can see every basepair at the
top of the display. Otherwise, there are several nucleotides under your mouse
cursor per pixel and instead of an actual score, the tooltip text can only show
the average score of all nucleotides under the cursor, which is indicated by
the prefix "~" in the mouseover and averages of scores are not useful for any
application of CADD.
Insertions and deletions:: Scores are also shown on mouseover for a +
Insertions and deletions: Scores are also shown on mouseover for a set of insertions and deletions. On hg38, the set has been obtained from Gnomad3. On hg19, the set of indels has been obtained from various sources (gnomAD2, ExAC, 1000 Genomes, ESP). If your insertion or deleletion of interest is not in the track, you will need to use CADD's online scoring tool to obtain them.
CADD scores are freely available for all non-commercial applications from the CADD website. For commercial applications, see the license instructions there.