c03e3225559110595d05d71774331201c15d914a kate Wed Feb 24 08:27:27 2021 -0800 Update and tighten wording in intro, update Nextstrain link. refs #25217 diff --git src/hg/htdocs/covid19.html src/hg/htdocs/covid19.html index 8826c63..250d543 100755 --- src/hg/htdocs/covid19.html +++ src/hg/htdocs/covid19.html @@ -12,76 +12,71 @@ <div class="col-md-6"> <p> The SARS-CoV-2 coronavirus emerged in December 2019 as a novel human pathogen causing a severe acute respiratory syndrome (COVID-19). The disease spread rapidly worldwide and was <A TARGET="_BLANK" HREF="https://www.who.int/dg/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19---11-march-2020"> declared a pandemic by the World Health Organization</a> on March 11, 2020. </p> <p> Genome sequencing of thousands of viral samples has helped researchers study mechanisms of infection, transmission and response of the human immune system. We at the <a target="_blank" href="https://ucscgenomics.soe.ucsc.edu/">UC Santa Cruz Genomics Institute</a> -are responding to the urgency of supporting biomedical research aimed at -developing treatments and a vaccine for this devastating illness by fast-tracking -visualization of genome sequences and analyses in the +are responding to the urgency of biomedical research to develop treaments and vaccines for this +devastating illness by fast-tracking visualization of genome sequences and analyses in the <a target="_blank" href="/cgi-bin/hgGateway?db=wuhCor1">UCSC Genome Browser for SARS-Cov-2</a>. -Moreover, we are incorporating relevant biomedical datasets such as single-cell lung gene +We are also incorporating relevant biomedical datasets such as single-cell lung gene expression into the -<a target="_blank" href="/singlecell.html">UCSC Cell Browser</a>, and are creating data tracks +<a target="_blank" href="/singlecell.html">UCSC Cell Browser</a>, and creating data tracks of -<a target="_blank" href="#covidHgiGwas">COVID-19 annotations in our Human Genome Browsers</a> -as datasets become publicly available. These annotations can further understanding of the +<a target="_blank" href="#covidHgiGwas">COVID-19 annotations in our Human Genome Browsers</a>. +These annotations can further understanding of the human genetic determinants of infection susceptibility, disease severity, and outcomes. </p> <p> Since the beginning of SARS-CoV-2 circulation in humans, the viral genome has been accummulating -mutations. Compared to other RNA viruses its mutation rate is low, but enough variants are known -to determine how samples cluster into groups and how they are related (see COVID-19 transmission map). -Mutations identified as important medically and epidemiologically are displayed in SARS-Cov-2 browser +mutations. +Mutations identified as important medically and epidemiologically are displayed in SARS-Cov-2 +browser tracks <a target="_blank" href="/cgi-bin/hgTrackUi?db=wuhCor1&g=variantMuts">Variants of Concern</a> and <a target="_blank" href="/cgi-bin/hgTrackUi?db=wuhCor1&g=spikeMuts">Spike Mutations</a>. Investigations of antibody resistance of viral mutations are available in the -<a target="_blank" href="/cgi-bin/hgTrackUi?db=wuhCor1&g=abEscape">Antibody Escape</a> track collection. -The B.1.1.7 variant of the virus, first identified in the UK and characterized as more infectious, -was first confirmed in the US in late December 2020. -The -<a target="_blank" href="/cgi-bin/hgTrackUi?db=wuhCor1&g=lineageB_1_1_7_US">B.1.1.7 in USA</a> track -provides a phylogenetic view of the first sequences from the US, and links to view phylogenetic analysis of -the subsequently identified geographic clusters (in New York, California, Colorado and Florida). +<a target="_blank" href="/cgi-bin/hgTrackUi?db=wuhCor1&g=abEscape">Antibody Escape</a> track +collection. </p> <p> A manuscript describing <a href="https://www.nature.com/articles/s41588-020-0700-8" target="_blank"> -The UCSC SARS-CoV-2 Genome Browser</a>, was published in the September 9 issue of <em>Nature Genetics</em>. +The UCSC SARS-CoV-2 Genome Browser</a>, was published in the September 9, 2020 issue of +<em>Nature Genetics</em>. </p> </div> <div class="col-md-6"> <img class="text-center" alt="COVID-19 transmission as of May 30, 2020, from Nextstrain" src="/images/covid19/covid19-transmission.may30_2020.nextstrain.png" style="margin-bottom: 5px !important"> <div style="text-align: right; line-height: 1"> <font SIZE=-1><em>COVID-19 transmission as of May 30, 2020</em><BR> </font> <font SIZE=-2> - <A HREF="https://nextstrain.org" - TARGET=_blank>Latest situation report from Nextstrain.org</a> + <A HREF="https://nextstrain.org/ncov/global" + TARGET=_blank>Latest global analysis from Nextstrain.org</a> </font> </div> </div> </div> <style> img { width: 100%; margin: 15px 0 !important; } </style> <div class="row"> <!-- Genome browser -->