0e9b24cc61c54f766934266e4f3246a3bbcda79e kuhn Mon Feb 15 14:32:11 2021 -0800 improved wording diff --git src/hg/makeDb/trackDb/human/covidHgiGwasR4.html src/hg/makeDb/trackDb/human/covidHgiGwasR4.html index 4e03962..3f39eb5 100644 --- src/hg/makeDb/trackDb/human/covidHgiGwasR4.html +++ src/hg/makeDb/trackDb/human/covidHgiGwasR4.html @@ -7,31 +7,31 @@ COVID-19 Host Genetics Initiative (HGI): a collaborative effort to facilitate the generation, analysis and sharing of COVID-19 host genetics research. The COVID-19 HGI organizes meta-analyses across multiple studies contributed by partners world-wide to identify the genetic determinants of SARS-CoV-2 infection susceptibility and disease severity and outcomes. Moreover, the COVID-19 HGI also aims to provide a platform for study partners to share analytical results in the form of summary statistics and/or individual level data where possible. At the time of this release, a total of 137 studies were registered with this effort.
The specific phenotypes studied by the COVID-19 HGI are those that benefit from maximal sample size: primary analysis on disease severity. For the Data Release 4 the number of cases have -increased by nearly ten-fold (over 30,000 COVID-19 cases and 1.47 million controls) by combining +increased by nearly ten-fold (more than 30,000 COVID-19 cases and 1.47 million controls) by combining data from 34 studies across 16 countries. The increased sample size resulted in strong evidence of seven genomic regions associated with severe COVID-19, on chromosomes 3, 6, 9, 12, 19, and 21; and one additional signal on chromosome 3 associated with COVID-19 partial-susceptibility. The four tracks here are based on data from HGI meta-analyses A2, B2, C1, and C2, described here: