0e9b24cc61c54f766934266e4f3246a3bbcda79e kuhn Mon Feb 15 14:32:11 2021 -0800 improved wording diff --git src/hg/makeDb/trackDb/human/covidHgiGwasR4.html src/hg/makeDb/trackDb/human/covidHgiGwasR4.html index 4e03962..3f39eb5 100644 --- src/hg/makeDb/trackDb/human/covidHgiGwasR4.html +++ src/hg/makeDb/trackDb/human/covidHgiGwasR4.html @@ -7,31 +7,31 @@ <b>COVID-19 Host Genetics Initiative (HGI)</b></a>: a collaborative effort to facilitate the generation, analysis and sharing of COVID-19 host genetics research. The COVID-19 HGI organizes meta-analyses across multiple studies contributed by <a target="_blank" href="https://www.covid19hg.org/partners/">partners world-wide</a> to identify the genetic determinants of SARS-CoV-2 infection susceptibility and disease severity and outcomes. Moreover, the COVID-19 HGI also aims to provide a platform for study partners to share analytical results in the form of summary statistics and/or individual level data where possible. At the time of this release, a total of 137 studies were registered with this effort. </p> <p> The specific phenotypes studied by the COVID-19 HGI are those that benefit from maximal sample size: primary analysis on disease severity. For the Data Release 4 the number of cases have -increased by nearly ten-fold (over 30,000 COVID-19 cases and 1.47 million controls) by combining +increased by nearly ten-fold (more than 30,000 COVID-19 cases and 1.47 million controls) by combining data from 34 studies across 16 countries. The increased sample size resulted in strong evidence of seven genomic regions associated with severe COVID-19, on chromosomes 3, 6, 9, 12, 19, and 21; and one additional signal on chromosome 3 associated with COVID-19 partial-susceptibility. The four tracks here are based on data from HGI meta-analyses A2, B2, C1, and C2, described here: </p> <ul> <li>Severe COVID GWAS (<b>A2</b>): Very severe respiratory confirmed covid vs. population (4933 cases from 14 studies)</li> <li>Hosp COVID GWAS (<b>B2</b>): Hospitalized covid vs. population (8638 cases from 23 studies)</li> <li>Tested COVID GWAS (<b>C1</b>): Covid vs. lab/self-reported negative (8638 cases from 23 studies)</li> <li>COVID GWAS (<b>C2</b>): Covid vs. population (30937 cases from 36 studies)</li> </ul> Due to privacy concerns, these browser tracks exclude some of the data in the full analysis results (specifically, data provided by 23andMe contributed studies). The actual study and case