4887b61d286a12e4eea1124c1f7685e9f4137ae6 jnavarr5 Tue Mar 2 16:07:20 2021 -0800 Removing an extra 'and' in the sentence, refs #18492 diff --git src/hg/makeDb/trackDb/human/caddSuper.html src/hg/makeDb/trackDb/human/caddSuper.html index 4913960..8de4584 100644 --- src/hg/makeDb/trackDb/human/caddSuper.html +++ src/hg/makeDb/trackDb/human/caddSuper.html @@ -5,31 +5,31 @@ CADD is a tool for scoring the deleteriousness of single nucleotide variants as well as insertion/deletions variants in the human genome.</p> <p> Some mutation annotations tend to exploit a single information type (e.g. phastCons or phyloP for conservation) and/or are restricted in scope (e.g. to missense changes). Thus, a broadly applicable metric that objectively weights and integrates diverse information is needed. Combined Annotation Dependent Depletion (CADD) is a framework that integrates multiple annotations into one metric by contrasting variants that survived natural selection with simulated mutations. </p> <p> CADD scores strongly correlate with allelic diversity, pathogenicity of both -coding and non-coding variants, and experimentally measured regulatory effects, +coding and non-coding variants, experimentally measured regulatory effects, and also highly rank causal variants within individual genome sequences. Finally, CADD scores of complex trait-associated variants from genome-wide association studies (GWAS) are significantly higher than matched controls and correlate with study sample size, likely reflecting the increased accuracy of larger GWAS. </p> <h2>Display Conventions and Configuration</h2> <p> There are six subtracks of this track: four for every possible single nucleotide mutation, one for insertions and one for deletions. All subtracks show the CADD Phred score on mouseover.<p> <p> <b>Single nucleotide variants (SNV):</b> For SNVs, at every