50d9c48ac1cbb26bfbbb5e132f69d5391d782f7d jnavarr5 Wed Mar 3 08:08:34 2021 -0800 Removing an 's' from deletions, refs #18492 diff --git src/hg/makeDb/trackDb/human/caddSuper.html src/hg/makeDb/trackDb/human/caddSuper.html index 8de4584..afcf99b 100644 --- src/hg/makeDb/trackDb/human/caddSuper.html +++ src/hg/makeDb/trackDb/human/caddSuper.html @@ -1,21 +1,21 @@ <h2>Description</h2> <p> This track collection shows <a href="https://cadd.gs.washington.edu/" target="_blank">Combined Annotation Dependent Depletion</a> scores. CADD is a tool for scoring the deleteriousness of single nucleotide variants as -well as insertion/deletions variants in the human genome.</p> +well as insertion/deletion variants in the human genome.</p> <p> Some mutation annotations tend to exploit a single information type (e.g. phastCons or phyloP for conservation) and/or are restricted in scope (e.g. to missense changes). Thus, a broadly applicable metric that objectively weights and integrates diverse information is needed. Combined Annotation Dependent Depletion (CADD) is a framework that integrates multiple annotations into one metric by contrasting variants that survived natural selection with simulated mutations. </p> <p> CADD scores strongly correlate with allelic diversity, pathogenicity of both coding and non-coding variants, experimentally measured regulatory effects, and also highly rank causal variants within individual genome sequences.