3feec259f20a7cc03affb9fae613492486bdd91a angie Wed Jul 28 15:41:37 2021 -0700 Move out the extraction of the public-sequences-only tree from the combined tree into a separate script for ease of manually continuing runs when there's a failure (most often matUtils annotate -P failing due to a changed path in the tree). diff --git src/hg/utils/otto/sarscov2phylo/updateCombinedTree.sh src/hg/utils/otto/sarscov2phylo/updateCombinedTree.sh index 91c8f79..fb3411d 100755 --- src/hg/utils/otto/sarscov2phylo/updateCombinedTree.sh +++ src/hg/utils/otto/sarscov2phylo/updateCombinedTree.sh @@ -17,33 +17,30 @@ prevDate=$1 problematicSitesVcf=$2 ottoDir=/hive/data/outside/otto/sarscov2phylo ncbiDir=$ottoDir/ncbi.latest cogUkDir=$ottoDir/cogUk.latest cncbDir=$ottoDir/cncb.latest gisaidDir=/hive/users/angie/gisaid minReal=20000 ref2bit=/hive/data/genomes/wuhCor1/wuhCor1.2bit epiToPublic=$gisaidDir/epiToPublicAndDate.latest scriptDir=$(dirname "${BASH_SOURCE[0]}") source $scriptDir/util.sh today=$(date +%F) -y=$(date +%Y) -m=$(date +%m) -d=$(date +%d) cd $ottoDir/$today prevProtobufMasked=$ottoDir/$prevDate/gisaidAndPublic.$prevDate.masked.pb usherDir=~angie/github/usher usher=$usherDir/build/usher matUtils=$usherDir/build/matUtils renaming=oldAndNewNames if [ ! -s new.masked.vcf.gz ]; then # Make lists of sequences already in the tree. $matUtils extract -i $prevProtobufMasked -u prevNames @@ -375,130 +372,57 @@ tail -n+2 $cncbDir/cncb.metadata.tsv \ | tawk '{ if ($3 != "GISAID" && $3 != "GenBank" && $3 != "Genbank") { print $2, "", $10, $11, $9, $5, $6} }' \ | sed -re 's@\t([A-Za-z -]+)( / [A-Za-z -'"'"']+)+\t@\t\1\t@; s/Sapiens/sapiens/;' \ | sort \ | join -t$'\t' -a 1 -o 1.1,1.2,1.3,1.4,1.5,1.6,1.7,2.2 - $cncbDir/nextclade.tsv \ | join -t$'\t' -a 1 -o 1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8,2.2 - $cncbDir/pangolin.tsv \ | join -t$'\t' -o 1.2,2.2,2.3,2.4,2.5,2.6,2.7,2.8,2.9 idToName - \ >> gisaidAndPublic.$today.metadata.tsv wc -l gisaidAndPublic.$today.metadata.tsv zcat $gisaidDir/metadata_batch_$today.tsv.gz \ | grep -Fwf <(cut -f 2 $renaming | grep EPI_ISL | cut -d\| -f 2) \ | tawk '{print $1 "|" $3 "|" $5, "", $5, $7, $15, $13, $14, $18, $19;}' \ >> gisaidAndPublic.$today.metadata.tsv wc -l gisaidAndPublic.$today.metadata.tsv -gzip gisaidAndPublic.$today.metadata.tsv +gzip -f gisaidAndPublic.$today.metadata.tsv # version/description files cncbDate=$(ls -l $cncbDir | sed -re 's/.*cncb\.([0-9]{4}-[0-9][0-9]-[0-9][0-9]).*/\1/') echo "sarscov2phylo release 13-11-20; GISAID, NCBI and COG-UK sequences downloaded $today; CNCB sequences downloaded $cncbDate" \ > version.plusGisaid.txt $matUtils extract -i gisaidAndPublic.$today.masked.pb -u samples.$today sampleCountComma=$(echo $(wc -l < samples.$today) \ | sed -re 's/([0-9]+)([0-9]{3})$/\1,\2/; s/([0-9]+)([0-9]{3},[0-9]{3})$/\1,\2/;') echo "$sampleCountComma genomes from GISAID, GenBank, COG-UK and CNCB ($today); sarscov2phylo 13-11-20 tree with newer sequences added by UShER" \ > hgPhyloPlace.plusGisaid.description.txt # Add nextclade annotations to protobuf time $matUtils annotate -T 50 \ -l \ -i gisaidAndPublic.$today.masked.pb \ -P ../nextstrain.clade-paths.tsv \ -o gisaidAndPublic.$today.masked.nextclade.pb # Add pangolin lineage annotations to protobuf. time $matUtils annotate -T 50 \ -i gisaidAndPublic.$today.masked.nextclade.pb \ -P ../pango.clade-paths.tsv \ -o gisaidAndPublic.$today.masked.nextclade.pangolin.pb mv gisaidAndPublic.$today.masked{,.unannotated}.pb -ln gisaidAndPublic.$today.masked.nextclade.pangolin.pb gisaidAndPublic.$today.masked.pb +ln -f gisaidAndPublic.$today.masked.nextclade.pangolin.pb gisaidAndPublic.$today.masked.pb # EPI_ISL_ ID to public sequence name mapping, so if users upload EPI_ISL IDs for which we have # public names & IDs, we can match them. cut -f 1,3 $epiToPublic > epiToPublic.latest # Update links to latest public+GISAID protobuf and metadata in hgwdev cgi-bin directories for dir in /usr/local/apache/cgi-bin{-angie,-beta,}/hgPhyloPlaceData/wuhCor1; do ln -sf `pwd`/gisaidAndPublic.$today.masked.pb $dir/public.plusGisaid.latest.masked.pb ln -sf `pwd`/gisaidAndPublic.$today.metadata.tsv.gz \ $dir/public.plusGisaid.latest.metadata.tsv.gz ln -sf `pwd`/hgPhyloPlace.plusGisaid.description.txt $dir/public.plusGisaid.latest.version.txt ln -sf `pwd`/epiToPublic.latest $dir/ done -# Extract public samples from tree -grep -v EPI_ISL_ samples.$today > newPublicNames -$matUtils extract -i gisaidAndPublic.$today.masked.pb \ - -s newPublicNames \ - -O -o public-$today.all.masked.pb -# Extract Newick and VCF from public-only tree -$matUtils extract -i public-$today.all.masked.pb \ - -t public-$today.all.nwk \ - -v public-$today.all.masked.vcf -gzip -f public-$today.all.masked.vcf -zcat gisaidAndPublic.$today.metadata.tsv.gz \ -| grep -v EPI_ISL_ \ -| gzip -c \ - > public-$today.metadata.tsv.gz - -# Add nextclade annotations to public protobuf -time $matUtils annotate -T 50 \ - -l \ - -i public-$today.all.masked.pb \ - -P ../nextstrain.clade-paths.public.tsv \ - -o public-$today.all.masked.nextclade.pb - -# Add pangolin lineage annotations to public protobuf -time $matUtils annotate -T 50 \ - -i public-$today.all.masked.nextclade.pb \ - -P ../pango.clade-paths.public.tsv \ - -o public-$today.all.masked.nextclade.pangolin.pb - -rm public-$today.all.masked.pb -ln -f public-$today.all.masked.nextclade.pangolin.pb public-$today.all.masked.pb - -cncbDate=$(ls -l $cncbDir | sed -re 's/.*cncb\.([0-9]{4}-[0-9][0-9]-[0-9][0-9]).*/\1/') -echo "sarscov2phylo release 13-11-20; NCBI and COG-UK sequences downloaded $today; CNCB sequences downloaded $cncbDate" \ - > version.txt - -$matUtils extract -i public-$today.all.masked.pb -u samples.public.$today -sampleCountComma=$(echo $(wc -l < samples.public.$today) \ - | sed -re 's/([0-9]+)([0-9]{3})$/\1,\2/; s/([0-9]+)([0-9]{3},[0-9]{3})$/\1,\2/;') -echo "$sampleCountComma genomes from GenBank, COG-UK and CNCB ($today); sarscov2phylo 13-11-20 tree with newer sequences added by UShER" \ - > hgPhyloPlace.description.txt - - -# Link to public trees download directory hierarchy -archiveRoot=/hive/users/angie/publicTrees -archive=$archiveRoot/$y/$m/$d -mkdir -p $archive -gzip -c public-$today.all.nwk > $archive/public-$today.all.nwk.gz -ln `pwd`/public-$today.all.masked.{pb,vcf.gz} $archive/ -gzip -c public-$today.all.masked.pb > $archive/public-$today.all.masked.pb.gz -ln `pwd`/public-$today.metadata.tsv.gz $archive/ -gzip -c public-$today.all.masked.nextclade.pangolin.pb \ - > $archive/public-$today.all.masked.nextclade.pangolin.pb.gz -gzip -c ../nextstrain.clade-paths.public.tsv > $archive/nextstrain.clade-paths.public.tsv.gz -gzip -c ../pango.clade-paths.public.tsv > $archive/pango.clade-paths.public.tsv.gz -ln `pwd`/hgPhyloPlace.description.txt $archive/public-$today.version.txt - -# Update 'latest' in $archiveRoot -ln -f $archive/public-$today.all.nwk.gz $archiveRoot/public-latest.all.nwk.gz -ln -f $archive/public-$today.all.masked.pb $archiveRoot/public-latest.all.masked.pb -ln -f $archive/public-$today.all.masked.pb.gz $archiveRoot/public-latest.all.masked.pb.gz -ln -f $archive/public-$today.all.masked.vcf.gz $archiveRoot/public-latest.all.masked.vcf.gz -ln -f $archive/public-$today.metadata.tsv.gz $archiveRoot/public-latest.metadata.tsv.gz -ln -f $archive/public-$today.version.txt $archiveRoot/public-latest.version.txt - -# Update hgdownload-test link for archive -mkdir -p /usr/local/apache/htdocs-hgdownload/goldenPath/wuhCor1/UShER_SARS-CoV-2/$y/$m -ln -sf $archive /usr/local/apache/htdocs-hgdownload/goldenPath/wuhCor1/UShER_SARS-CoV-2/$y/$m - -# Update links to latest public protobuf and metadata in hgwdev cgi-bin directories -for dir in /usr/local/apache/cgi-bin{-angie,-beta,}/hgPhyloPlaceData/wuhCor1; do - ln -sf `pwd`/public-$today.all.masked.pb $dir/public-latest.all.masked.pb - ln -sf `pwd`/public-$today.metadata.tsv.gz $dir/public-latest.metadata.tsv.gz - ln -sf `pwd`/hgPhyloPlace.description.txt $dir/public-latest.version.txt -done +$scriptDir/extractPublicTree.sh $today