19870454d7c3d8f29a5800477bcaa36babee5a98 dschmelt Tue Nov 2 17:10:33 2021 -0700 Finishing Development for jaspar update refs #28322 diff --git src/hg/makeDb/trackDb/human/jaspar.html src/hg/makeDb/trackDb/human/jaspar.html index aca3fcd..e65cf56 100644 --- src/hg/makeDb/trackDb/human/jaspar.html +++ src/hg/makeDb/trackDb/human/jaspar.html @@ -1,20 +1,20 @@ <h2>Description</h2> <p> This track represents genome-wide predicted binding sites for TF (transcription factor) binding profiles in the -<a href="https://jaspar.genereg.net//about/" target="_blank">JASPAR +<a href="https://jaspar.genereg.net/about/" target="_blank">JASPAR CORE collection</a>. This open-source database contains a curated, non-redundant set of binding profiles derived from published collections of experimentally defined transcription factor binding sites for eukaryotes.</p> <h2>Display Conventions and Configuration</h2> <p> Shaded boxes represent predicted binding sites for each of the TF profiles in the JASPAR CORE collection. The shading of the boxes indicates the p-value of the profile's match to that position (scaled between 0-1000 scores, where 0 corresponds to a p-value of 1 and 1000 to a p-value ≤ 10<sup>-10</sup>). Thus, the darker the shade, the lower (better) the p-value.</p> <p> The default view only shows predicted binding sites with scores of 400 or greater. @@ -79,33 +79,34 @@ <td style="padding:10px">0.049</td> <td style="padding:10px">10<sup>-2</sup></td> <td style="padding:10px">10<sup>-3</sup></td> <td style="padding:10px">10<sup>-4</sup></td> <td style="padding:10px">10<sup>-5</sup></td> <td style="padding:10px">10<sup>-6</sup></td> <td style="padding:10px">10<sup>-7</sup></td> <td style="padding:10px">10<sup>-8</sup></td> <td style="padding:10px">10<sup>-9</sup></td> <td style="padding:10px">≤ 10<sup>-10</sup></td> </tr> </table> <h2>Methods</h2> <p> -JASPAR 2022 contains updates transcription factor binding sites +JASPAR 2022 contains updated transcription factor binding sites with additional transcription factor profiles. More information on -the methods can be found in the upcoming publication.</p> +the methods can be found in their upcoming publication or on the +<a href="https://jaspar.genereg.net/" target="_blank">JASPAR website</a>.</p> <p> JASPAR 2020 scanned DNA sequences with JASPAR CORE TF-binding profiles for each taxa independently using PWMScan. TFBS predictions were selected with a PWM relative score ≥ 0.8 and a p-value < 0.05. P-values were scaled between 0 (corresponding to a p-value of 1) and 1000 (p-value ≤ 10<sup>-10</sup>) for colouring of the genome tracks and to allow for comparison of prediction confidence between different profiles.</p> <p> JASPAR 2018 used the TFBS Perl module (Lenhard and Wasserman 2002) and FIMO (Grant, Bailey, and Noble 2011), as distributed within the MEME suite (version 4.11.2) (Bailey <em>et al.</em> 2009). For scanning genomes with the BioPerl TFBS module, profiles were converted to PWMs and matches were kept with a relative score ≥ 0.8. For the FIMO scan, profiles were reformatted to MEME motifs @@ -152,33 +153,32 @@ <a href="../cgi-bin/hgHubConnect?hubSearchTerms=jaspar&hgHub_do_search=on"> Public Hub</a> or by clicking the assembly links below:</p> <table width="458" border="1"> <tbody> <tr> <td><strong>Species</strong></td> <td><strong>Genome assembly versions</strong></td> </tr> <tr> <td width="300">Human - <em>Homo sapiens</em></td> <td width="200"><a target="_blank" href="../cgi-bin/hgTrackUi?db=hg19&g=jaspar">hg19</a>, <a target="_blank" href="../cgi-bin/hgTrackUi?db=hg38&g=jaspar">hg38</a></td> </tr> <tr> <td>Mouse - <em>Mus musculus</em></td> - <td><a target="_blank" -href="../cgi-bin/hgTracks?db=mm10&hubUrl=http://expdata.cmmt.ubc.ca/JASPAR/UCSC_tracks/hub.txt"> -mm10</a></td> + <td><a target="_blank" href="../cgi-bin/hgTrackUi?db=mm10&g=jaspar">mm10</a>, +<a target="_blank" href="../cgi-bin/hgTrackUi?db=mm39&g=jaspar">mm39</a></td> </tr> <tr> <td>Zebrafish - <em>Danio rerio</em></td> <td><a target="_blank" href="../cgi-bin/hgTracks?db=danRer11&hubUrl=http://expdata.cmmt.ubc.ca/JASPAR/UCSC_tracks/hub.txt">danRer11</a></td> </tr> <tr> <td>Fruitfly - <em>Drosophila melanogaster</em></td> <td><a target="_blank" href="../cgi-bin/hgTracks?db=dm6&hubUrl=http://expdata.cmmt.ubc.ca/JASPAR/UCSC_tracks/hub.txt">dm6</a></td> </tr> <tr> <td>Nematode - <em>Caenorhabditis elegans</em></td> <td><a target="_blank" href="../cgi-bin/hgTracks?db=ce10&hubUrl=http://expdata.cmmt.ubc.ca/JASPAR/UCSC_tracks/hub.txt">ce10</a></td>