319fba7ba20ec5769939efc9237b6c3cd2dd1f76 dschmelt Tue May 3 16:07:48 2022 -0700 Typo fix #29206 diff --git src/hg/htdocs/goldenPath/newsarch.html src/hg/htdocs/goldenPath/newsarch.html index 86f5ebf..e098e79 100755 --- src/hg/htdocs/goldenPath/newsarch.html +++ src/hg/htdocs/goldenPath/newsarch.html @@ -112,31 +112,31 @@ <li> <a target="_blank" href="/cgi-bin/hgTrackUi?db=hg38&g=skinSoleBoldo&position=default">Skin Sole-Boldo</a> </li> </ul> We hope that this combined format will facilitate research and comparison with the recently released <a href="#033122">Tabula Sapiens</a> expression tracks. </p> END PREPPED FOR RELEASE --> <a name="050322"></a> <h2>May 3, 2022 New GnomAD Mutation Constraint track on GRCh38/hg38</h2> <p> We have just released the <b>GnomAD Genomes Mutation Constraint</b> track on the human GRCh38/hg38 genome assembly. This track's data is based on GnomAD v3.1.2 and shows relative frequency of variation in 1 kilobase windows across the entire genome. -This quantifies population occurance of disruptive variation caused by purifying natural +This quantifies population occurrence of disruptive variation caused by purifying natural selection, similar to negative selection on loss-of-function (LoF) for genes, but calculated for non-coding regions too. View the complete set of GnomAD tracks and read more on the <a href="/cgi-bin/hgTrackUi?db=hg38&g=gnomadVariants">GnomAD description page</a>. <a name="050222"></a> <h2>May 2, 2022 New Track Hub bigBarChart display and selection features</h2> <p> We are pleased to announce new settings to support the display of bigBarChart data in Track Hubs. <a href="help/hgTrackHubHelp.html#Intro">Track Hubs</a> are web-accessible directories of genomic data that can be viewed on the UCSC Genome Browser. Track Hubs allow a lab to share and host all their genomic data (<a href="help/bam.html">BAMs</a>, <a href="help/vcf.html">VCFs</a>, etc.) via a single Genome Browser link. The <a href="help/barChart.html">bigBarChart</a> track format displays a bar graph of category-specific values over genomic regions and is useful for displaying gene expression across a spectrum of tissues or other datasets where it is desirable to compare a set of related variables over specific genomic regions.</p> @@ -558,30 +558,32 @@ also like to thank Brian Raney and Jairo Navarro for the development and release of this track.</p> <a name="022522"></a> <h2>Feb. 25, 2022 New COVID track on Drug Resistance Mutations</h2> <p> We have just added the <a href="/cgi-bin/hgTrackUi?db=wuhCor1&g=resist">Drug Resistance</a> track to the SARS-CoV-2 (COVID-19) genome. This track shows 5 amino acid variants documented to confer drug treatment resistance to Remdesivir. Try it yourself:</p> <p> <a href=" https://genome.ucsc.edu/s/view/DrugResistance">https://genome.ucsc.edu/s/view/DrugResistance</a> </p> <p>We would like to thank data contributor Paul Gordon for making the data accessible on his <a href="https://people.ucalgary.ca/~gordonp/remdesivir_failure-RdRp.html"> University of Calgary website</a>.</p> +<p>Note, this track was updated on May, 3rd 2022. New data on Sotrovimab drug resistance +mutations were added via collaboration with Anna Niewiadomska from JCVI.</p> <a name="022222"></a> <h2>Feb. 22, 2022 Recommended Track Sets paper</h2> <p> We are pleased to announce a new paper about our Recommended Tracks Set feature, available on GRCh37/hg19, which collects related clinical tracks to help investigate variants. The paper, <a href="https://doi.org/10.1002/humu.24335" target="_blank">Variant interpretation: UCSC Genome Browser Recommended Track Sets</a>, covers how this new feature can facilitate the interpretation of variants for clinicians.</p> <p> Track Sets allow a user to quickly swap out the on-screen annotations they may be looking at for a different set of tracks relevant to specific medical scenarios: investigating single nucleotide variants in coding regions (Clinical SNVs), structural copy number variants (Clinical CNVs), and functional aspects of non-coding variants (Non-coding SNVs).</p> <p class ="text-center">