775dc94f2a27a50f782ee886a0dddddff41d0065 dschmelt Mon May 2 17:09:38 2022 -0700 Pushing and announcing gnomAD Mut constraint #29026 diff --git src/hg/htdocs/goldenPath/newsarch.html src/hg/htdocs/goldenPath/newsarch.html index 88e7952..86f5ebf 100755 --- src/hg/htdocs/goldenPath/newsarch.html +++ src/hg/htdocs/goldenPath/newsarch.html @@ -106,30 +106,41 @@ <li> <a target="_blank" href="/cgi-bin/hgTrackUi?db=hg38&g=placentaVentoTormo&position=default">Placenta Vento-Tormo</a> </li> <li> <a target="_blank" href="/cgi-bin/hgTrackUi?db=hg38&g=rectumWang&position=default">Rectum Wang</a> </li> <li> <a target="_blank" href="/cgi-bin/hgTrackUi?db=hg38&g=skinSoleBoldo&position=default">Skin Sole-Boldo</a> </li> </ul> We hope that this combined format will facilitate research and comparison with the recently released <a href="#033122">Tabula Sapiens</a> expression tracks. </p> END PREPPED FOR RELEASE --> +<a name="050322"></a> +<h2>May 3, 2022 New GnomAD Mutation Constraint track on GRCh38/hg38</h2> +<p> +We have just released the <b>GnomAD Genomes Mutation Constraint</b> track on the human GRCh38/hg38 +genome assembly. This track's data is based on GnomAD v3.1.2 and shows +relative frequency of variation in 1 kilobase windows across the entire genome. +This quantifies population occurance of disruptive variation caused by purifying natural +selection, similar to negative selection on loss-of-function (LoF) for genes, but +calculated for non-coding regions too. View the complete set of GnomAD tracks and read more on the +<a href="/cgi-bin/hgTrackUi?db=hg38&g=gnomadVariants">GnomAD description page</a>. + <a name="050222"></a> <h2>May 2, 2022 New Track Hub bigBarChart display and selection features</h2> <p> We are pleased to announce new settings to support the display of bigBarChart data in Track Hubs. <a href="help/hgTrackHubHelp.html#Intro">Track Hubs</a> are web-accessible directories of genomic data that can be viewed on the UCSC Genome Browser. Track Hubs allow a lab to share and host all their genomic data (<a href="help/bam.html">BAMs</a>, <a href="help/vcf.html">VCFs</a>, etc.) via a single Genome Browser link. The <a href="help/barChart.html">bigBarChart</a> track format displays a bar graph of category-specific values over genomic regions and is useful for displaying gene expression across a spectrum of tissues or other datasets where it is desirable to compare a set of related variables over specific genomic regions.</p> <p> Two new settings <a href="help/trackDb/trackDbHub.html#barChartBarMinWidth">barChartBarMinWidth</a> and <a href="help/trackDb/trackDbHub.html#barChartBarMinPadding">barChartBarMinPadding</a> allow customizing the width and padding between bars as can be seen in these two example