d0f769fd1aadc0641c34e742791c2ad9e27f5f7b
lrnassar
  Wed Jul 6 10:02:33 2022 -0700
Fixing up the track desc in response by author, refs #23883

diff --git src/hg/makeDb/trackDb/human/constraintSuper.html src/hg/makeDb/trackDb/human/constraintSuper.html
index 20c5b5a..59cb427 100644
--- src/hg/makeDb/trackDb/human/constraintSuper.html
+++ src/hg/makeDb/trackDb/human/constraintSuper.html
@@ -33,31 +33,32 @@
     <li><b><a href="https://www.cardiodb.org/hmc/" target="_blank">
     HMC - Homologous Missense Constraint</a></b>:
     Homologous Missense Constraint (HMC) is a amino acid level measure
     of genetic intolerance of missense variants within human populations.
     For all assessable amino-acid positions in Pfam domains, the number of
     missense substitutions directly observed in gnomAD (Observed) was counted
     and compared to the expected value under a neutral evolution
     model (Expected). The upper limit of a 95% confidence interval for the
     Observed/Expected ratio is defined as the HMC score. Missense variants
     disrupting the amino-acid positions with HMC&lt;0.8 are predicted to be
     likely deleterious.
 
     <li><b><a href="https://stuart.radboudumc.nl/metadome/" target="_blank">
     MetaDome - Tolerance Landscape Score</a> (hg19 only)</b>:
     MetaDome Tolerance Landscape scores are computed as a missense over synonymous 
-    variant count ratio, which is calculated in a sliding window manner to provide 
+    variant count ratio, which is calculated in a sliding window (with a size of 21 
+    codons/residues) manner to provide 
     a per-position indication of regional tolerance to missense variation. The 
     variants are based on gnomAD and corrected for codon composition. Scores 
     &lt;0.7 are considered intolerant.
    
     <li><b><a href="http://biosig.unimelb.edu.au/mtr-viewer/" target="_blank">
     MTR - Missense Tolerance Ratio</a> (hg19 only)</b>:
     Missense Tolerance Ratio (MTR) scores aim to quantify the amount of purifying 
     selection acting specifically on missense variants in a given window of 
     protein-coding sequence. It is estimated across sliding windows of 31 codons 
     (default) and uses observed standing variation data from the WES component of 
     gnomAD / the Exome Aggregation Consortium Database (ExAC), version 2.0. Scores
     were computed using Ensembl v95 release.
 </ol>
 
 <h2>Display Conventions and Configuration</h2>