035323fe4a88aea8872eb11de17a3800321cf8e7 galt Wed Jan 18 19:59:51 2023 -0800 code cleanup based on htmlCheck output. refs #7914 diff --git src/hg/makeDb/trackDb/sacCer/uwFootprints.html src/hg/makeDb/trackDb/sacCer/uwFootprints.html index 13ccab0..69d52a8 100644 --- src/hg/makeDb/trackDb/sacCer/uwFootprints.html +++ src/hg/makeDb/trackDb/sacCer/uwFootprints.html @@ -1,19 +1,15 @@ -<html> -<title>UW protein binding footprints</title> -<body> - <h1>Description</h1> <p> The orchestrated binding of transcriptional activators and repressors to specific DNA sequences in the context of chromatin defines the regulatory program of eukaryotic genomes. We developed a digital approach to assay regulatory protein occupancy on genomic DNA in vivo by dense mapping of individual DNase I cleavages from intact nuclei using massively parallel DNA sequencing. Analysis of >23 million cleavages across the <i>Saccharomyces cerevisiae</i> genome revealed thousands of protected regulatory protein footprints, enabling <i>de novo</i> derivation of factor binding motifs as well as the identification of hundreds of novel binding sites for major regulators. We observed striking correspondence between nucleotide-level DNase I cleavage patterns and protein-DNA @@ -77,17 +73,15 @@ S. Kuehn, William S. Noble (william-noble@u.washington.edu), Stanley Fields (fields@u.washington.edu) and John A. Stamatoyannopoulos (jstam@stamlab.org).</p> <h1>References</h1> <p> Hesselberth JR, Chen X, Zhang Z, Sabo PJ, Sandstrom R, Reynolds AP, Thurman RE, Neph S, Kuehn MS, Noble WS <em>et al</em>. <a href="https://www.nature.com/articles/nmeth.1313" target="_blank"> Global mapping of protein-DNA interactions <i>in vivo</i> by digital genomic footprinting</a>. <em>Nat Methods</em>. 2009 Apr;6(4):283-9. PMID: <a href="https://www.ncbi.nlm.nih.gov/pubmed/19305407" target="_blank">19305407</a>; PMC: <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2668528/" target="_blank">PMC2668528</a> </p> -</body> -</html>