This track shows potential enhancers whose activity was experimentally validated in transgenic mice. +Most of these noncoding elements were selected for testing based on their extreme conservation in +other vertebrates or epigenomic evidence (ChIP-Seq) of putative enhancer marks. More information +can be found on the VISTA Enhancer Browser +page. +
+ +Items appearing in red (positive) indicate that a reproducible +pattern was observed in the in vivo enhancer assay. Items appearing in +blue (negative) indicate that NO reproducible pattern was observed +in the in vivo enhancer assay. Note that this annotation refers only to the single developmental +timepoint that was tested in this screen (e11.5) and does not exclude the possibility that this +region is a reproducible enhancer active at earlier or later timepoints in development. +
+ +Excerpted from the Vista Enhancer Mouse Enhancer Screen Handbook and Methods page at the Lawrence Berkeley +National Laboratory (LBNL) website: +
Most enhancer candidate sequences are identified by extreme evolutionary sequence conservation or +by ChIP-seq. Detailed information related to enhancer identification by extreme evolutionary +conservation can be found in the following publications: +
+Detailed information related to enhancer identification by ChIP-seq can be found in the +following publications:
+See the Transgenic Mouse Assay section for experimental procedures that were used to perform the +transgenic assays: Mouse Enhancer Screen Handbook and Methods + +
UCSC converted the +Experimental Data for hg19 and mm9 into bigBed format using the bedToBigBed +utility. The data for hg38 was lifted over from hg19. The data for mm10 and mm39 were lifted over +from mm9.
+ ++VISTA Enhancers data can be explored interactively with the +Table Browser and cross-referenced with the +Data Integrator. For programmatic access, +the track can be accessed using the Genome Browser's +REST API. +ReMap annotations can be downloaded from the +Genome Browser's download server +as a bigBed file. This compressed binary format can be remotely queried through +command line utilities. Please note that some of the download files can be quite large.
+ +Thanks to the Lawrence Berkeley National Laboratory for providing this data
+ + ++Visel A, Minovitsky S, Dubchak I, Pennacchio LA. + +VISTA Enhancer Browser--a database of tissue-specific human enhancers. +Nucleic Acids Res. 2007 Jan;35(Database issue):D88-92. +PMID: 17130149; PMC: PMC1716724 +