c1d527b5f7544b6a5a3fc0bf49938ae61955a1a8 angie Tue Mar 5 11:00:42 2024 -0800 More masked sites in BA.2.86 from inspection of tree in taxonium, and JN.1 from github issue. diff --git src/hg/utils/otto/sarscov2phylo/branchSpecificMask.yml src/hg/utils/otto/sarscov2phylo/branchSpecificMask.yml index c31b082..c13e0a9 100644 --- src/hg/utils/otto/sarscov2phylo/branchSpecificMask.yml +++ src/hg/utils/otto/sarscov2phylo/branchSpecificMask.yml @@ -96,39 +96,53 @@ # XBS: A22190G, G22331A, G22577C, G22898A, A26275G BN.1.2.3: # Inherits from BA.2.75 representative: England/QEUH-326228D4/2022 sites: [ 337 # https://github.com/cov-lineages/pango-designation/issues/2016#issuecomment-1626159006 ] BA.2.86: # Inherits from BA.2 # @Over-There-Is requested 21610 - very messy indeed. # https://github.com/sars-cov-2-variants/lineage-proposals/issues/606#issuecomment-1801095482 # @aviczhl2 pointed out some recurring reversions: # https://github.com/sars-cov-2-variants/lineage-proposals/issues/1072 representative: OY747147.1 - ranges: [ [ 21765, 21770 ], # https://github.com/sars-cov-2-variants/lineage-proposals/issues/606 + ranges: [ [ 21294, 21296 ], # run of muts, makes a mini-JN.1 + [ 21539, 21542 ], # run of muts, France/...-HCL, makes a mini-JN.1 + [ 21765, 21770 ], # https://github.com/sars-cov-2-variants/lineage-proposals/issues/606 [ 21610, 21624 ], # https://github.com/sars-cov-2-variants/lineage-proposals/issues/1347 [ 21625, 21631 ], # https://github.com/sars-cov-2-variants/lineage-proposals/issues/1380 [ 22194, 22196 ] ] # https://github.com/sars-cov-2-variants/lineage-proposals/issues/1380 sites: [ 58, 59, # https://github.com/sars-cov-2-variants/lineage-proposals/issues/1089 13427, # https://github.com/sars-cov-2-variants/lineage-proposals/issues/1313 21302, 21304, 21305, # https://github.com/sars-cov-2-variants/lineage-proposals/issues/1190 ] - reversions: [ T21711C, C22032T, A22033C, G22034A, A22770G, A23012G, G26610A ] + reversions: [ T21711C, C22032T, A22033C, G22034A, A22770G, A23012G, G26610A, + # Added 2024-03-01 because they're causing reversion branches with >= 100 samples. + # Unfortunately 6183 and 9142 will be incorrect in XDD, XDR, XDS. + T2790C, T4321C, G6183A, T9142C, C13339T, A22353C, G22556A, C22577G, T22674C, + T22686C, G22688A, T22813G, C22895G, A22896T, A22898G, T22916C, G22917T, A22942T, + A23005T, C23075T, G23599T, G23604C, T24378C, T26858C, + ] + +JN.1: + # Inherits from BA.2.86 + representative: Denmark/DCGC-661561/2023 + ranges: [ [ 23009, 23011 ], # https://github.com/cov-lineages/pango-designation/issues/2510 + ] BA.4: # BA.4 is placed on the BA.2 branch so it inherits all the BA.2 sites. representative: SouthAfrica/NICD-N41664/2022 ranges: [ [ 686, 694 ], [ 21765, 21770 ] ] BA.5: # BA.5 is placed on the BA.2 branch so it inherits all the BA.2 sites. representative: England/PHEP-YYFJPAM/2022 ranges: [ [ 21765, 21770 ] ] # Some of these should be reverted in recombinants, but we're pretty much past the point of # simultaneous Delta/Omicron and the noise from false reversions is so intolerable that we'll # just have to watch out for missing reversions when working with recombinants. # False muts in recombinants that were later re-placed in BA.2.75: # XBD: G12160A, T22917G, T23018G