9804a48d4ee019ce876c5eb2f98239830a2ef766 angie Tue Sep 10 14:03:32 2024 -0700 Mask artifactual reversions in KP.3.1.1. diff --git src/hg/utils/otto/sarscov2phylo/branchSpecificMask.yml src/hg/utils/otto/sarscov2phylo/branchSpecificMask.yml index 7022b12..1096625 100644 --- src/hg/utils/otto/sarscov2phylo/branchSpecificMask.yml +++ src/hg/utils/otto/sarscov2phylo/branchSpecificMask.yml @@ -136,30 +136,39 @@ representative: Denmark/DCGC-661561/2023 ranges: [ [ 23008, 23011 ], # https://github.com/cov-lineages/pango-designation/issues/2510 ] sites: [ 1871, # https://github.com/sars-cov-2-variants/lineage-proposals/issues/1466 1368, # GBW artifact, email from FedeGueli 6569, # '' 17562, # very homoplasic (or systematic error?) in JN.1, email from FedeGueli ] KP.1: # Inherits from JN.1 representative: England/CLIMB-CM7YEN1U/2024 reversions: [ T17334G # Reversion of JN.1.11.1 mutation, email from FedeGueli ] +KP.3.1.1: + # Inherits from JN.1 + representative: England/CLIMB-CM7YJCHG/2024 + reversions: [ C22926T, # https://github.com/sars-cov-2-variants/lineage-proposals/issues/1914 + C22928T, # '' + # Others I noticed while looking at the above: + G7842A, T23948G, C3565T, T17334G, G19722A, G23055A, T28271A, T23063A, G22910A + ] + BA.4: # BA.4 is placed on the BA.2 branch so it inherits all the BA.2 sites. representative: SouthAfrica/NICD-N41664/2022 ranges: [ [ 686, 694 ], [ 21765, 21770 ] ] BA.5: # BA.5 is placed on the BA.2 branch so it inherits all the BA.2 sites. representative: England/PHEP-YYFJPAM/2022 ranges: [ [ 21765, 21770 ] ] # Some of these should be reverted in recombinants, but we're pretty much past the point of # simultaneous Delta/Omicron and the noise from false reversions is so intolerable that we'll # just have to watch out for missing reversions when working with recombinants. # False muts in recombinants that were later re-placed in BA.2.75: # XBD: G12160A, T22917G, T23018G # XBP: G12160A,