2e3c89f43f3bb9d386178270200d0acce9fc8050 lrnassar Fri Nov 22 17:47:13 2024 -0800 Giving the UI link cronjob some love by fixing all the 301 redirects. These are the bulk of the items listed on the cron. No RM. diff --git src/hg/makeDb/trackDb/human/hgdpFst.html src/hg/makeDb/trackDb/human/hgdpFst.html index 4a16ed10..bb54d08 100644 --- src/hg/makeDb/trackDb/human/hgdpFst.html +++ src/hg/makeDb/trackDb/human/hgdpFst.html @@ -1,84 +1,84 @@ <H2>Description</H2> <P> In this track, the value shown for each SNP is -log<sub>10</sub> of the fraction of SNPs with a more extreme F<sub>ST</sub> value than that SNP. Relative F<sub>ST</sub> (also known as the <A HREF="https://en.wikipedia.org/wiki/Fixation_index" TARGET=_BLANK>Fixation index</A>) values were calculated from SNPs genotyped in 53 populations worldwide by the <A HREF="https://morrisoninstitute.stanford.edu/" TARGET=_BLANK>Human Genome Diversity Project</A> in collaboration with the <A HREF="https://cephb.fr/en/index.php" TARGET=_BLANK>Centre d'Etude du Polymorphisme Humain</A> (HGDP-CEPH). This track and several others are available from the <A HREF="http://hgdp.uchicago.edu/" TARGET=_BLANK>HGDP Selection Browser</A>. </P> <P> From <A HREF="https://en.wikipedia.org/wiki/Fixation_index" TARGET=_BLANK>Wikipedia</A>: <blockquote> Fixation index (F<sub>ST</sub>) is a measure of population differentiation based on genetic polymorphism data, such as Single nucleotide polymorphisms (SNPs) or microsatellites. It is a special case of <A HREF="https://en.wikipedia.org/wiki/F-statistics" TARGET=_BLANK>F-statistics</A>, the concept developed in the 1920s by Sewall Wright. This statistic compares the genetic variability within and between populations and is frequently used in the field of population genetics. </blockquote> -From <A HREF="http://www.uwyo.edu/dbmcd/popecol/maylects/popgengloss.html" +From <A HREF="https://www.uwyo.edu/dbmcd/popecol/maylects/popgengloss.html" TARGET=_BLANK>http://www.uwyo.edu/dbmcd/popecol/Maylects/PopGenGloss.html</A>: <blockquote> F<sub>ST</sub> is the proportion of the total genetic variance contained in a subpopulation (the S subscript) relative to the total genetic variance (the T subscript). Values can range from 0 to 1. High F<sub>ST</sub> implies a considerable degree of differentiation among populations. </blockquote> </P> <H2>Methods</H2> <P> Samples collected by the HGDP-CEPH from 1,043 individuals from around the world were genotyped for 657,000 SNPs at <A HREF="https://hagsc.org/hgdp/" TARGET=_BLANK>Stanford</A>. The 53 populations were divided into seven continental groups: Africa, Middle East, Europe, South Asia, East Asia, Oceania and the Americas. F<sub>ST</sub> was computed for all SNPs, and then each SNP's place in the empirical F<sub>ST</sub> distribution was used to derive the scores shown in this track, -log<sub>10</sub> of the fraction of SNPs with a more extreme F<sub>ST</sub> value than that SNP. </P> <H2>Credits</H2> <P> Thanks to the HGDP-CEPH and Joe Pickrell in the <A HREF="http://web.stanford.edu/group/pritchardlab/home.html"TARGET=_BLANK>Pritchard lab</A> at the University of Chicago for providing these data. </P> <H2>References</H2> <P> Pickrell JK, Coop G, Novembre J, Kudaravalli S, Li J, Absher D, Srinivasan BS, Barsh GS, Myers RM, Feldman MW, Pritchard JK. <A HREF="https://www.ncbi.nlm.nih.gov/pubmed/19307593?dopt=Abstract" TARGET=_BLANK>Signals of recent positive selection in a worldwide sample of human populations</A>. <em>Genome Res.</em> 2009 May;19(5):826-37.</P> <P> Li JZ, Absher DM, Tang H, Southwick AM, Casto AM, Ramachandran S, Cann HM, Barsh GS, Feldman M, Cavalli-Sforza LL, Myers RM. <A HREF="https://www.ncbi.nlm.nih.gov/pubmed/18292342?dopt=Abstract" TARGET=_BLANK>Worldwide human relationships inferred from genome-wide patterns of variation</A>. <em>Science</em>. 2008 Feb 22;319(5866):1100-4.</P> <P> Cann HM, de Toma C, Cazes L, Legrand MF, Morel V, Piouffre L, Bodmer J, Bodmer WF, Bonne-Tamir B, Cambon-Thomsen A <em>et al.</em> <A HREF="https://www.ncbi.nlm.nih.gov/pubmed/11954565?dopt=Abstract" TARGET=_BLANK>A human genome diversity cell line panel</A>. <em>Science</em>. 2002 Apr 12;296(5566):261-2.</P>