cb4c5ca53034c40e1255903d5c993aff2c49d053 jnavarr5 Mon Feb 10 16:09:38 2025 -0800 Adding a link to the CIViC website to the track description page. Fixing a few typos in the text. Replacing double quotes with the HTML entity. refs #34371 diff --git src/hg/makeDb/trackDb/human/civic.html src/hg/makeDb/trackDb/human/civic.html index 434564da711..0bca5656f8c 100644 --- src/hg/makeDb/trackDb/human/civic.html +++ src/hg/makeDb/trackDb/human/civic.html @@ -1,44 +1,45 @@

Description

-This track shows genomic locations for variants in the CIViC (Clinical -Interpretation of Variants in Cancer) database. These clinically +This track shows genomic locations for variants in the +CIViC (Clinical +Interpretation of Variants in Cancer) database. These clinically relevant variant interpretations are expert- and crowd-sourced from peer-revied literature, clinical trials, and some conference abstracts.

Each variant's interpretation is in the context of a broder molecular profile: one or more variants grouped together. For example, clinical evidence may be relevant to a KRAS G12 mutation on its own, but other clinical evidence may relevant for cases with either a mutation in KRAS G12 or G13.

The primary points of data from the scientific literature are curated as Clinical Evidence, which connects to a molecular profile, which in turn connects to the variants shown in this track. Groups of evidence can become curator Assertions about the relevence of a molecular profile.

The detail for a feature will list diseases and therapies that have been associated with a genomic variant. Visiting the CIViC page for a variant will allow browsing the Molecular Profiles associated with that variant, and in turn each Molecular Profile shows the Clinical -Evidence and Assertions for variou diseases and therapies. +Evidence and Assertions for various diseases and therapies.

Display Conventions and Configuration

There are three types of variant feature types in CIViC: gene, fusion, and factor, of which only the gene and fusion fetaures have a genomic location.

Gene variants are shown as a single item, with a name indicating the variant's mode: sequence change, gene expression, gene deletion, etc.

Fusion variants connect two genes via a structural DNA rearrangement, @@ -47,31 +48,32 @@ thick bar. If there is an intron associated with the fusion, it will be annotated as a thin bar on the feature.

Data updates

This track reflects the monthly data summaries published by CIViC. The latest information is always available directly on the CIViC website or by its API.

Data access

The raw data can be explored interactively with the Table Browser or the Data Integrator. The data can be -accessed from scripts through our API, via the track name "civic". +accessed from scripts through our API, via the track name +"civic".

Methods

The monthly CIViC Variant Summaries were reformatted at UCSC to bigBed format. The data is updated every month, the week after CIViC data summary release. The diseases and therapies associated with a variant are collected from the corresponding TSV files from CIViC, using the molecular profile summaries as a mapping.

Credits

Thanks to the CIViC contributers and organizers for curating the