For automated download and analysis, the genome annotation is stored at UCSC in bigWig format that can be downloaded from our download server. The files for this track are called a.bw, c.bw, g.bw, t.bw. Individual regions or the whole genome annotation can be obtained using our tool bigWigToWig which can be compiled from the source code or downloaded as a precompiled binary for your system. Instructions for downloading source code and binaries can be found here. For example, to extract only annotations in a given region, you could use the following command: +
+bigWigToBedGraph -chrom=chr1 -start=100000 -end=100500 http://hgdownload.soe.ucsc.edu/gbdb/$db/alphaMissense/a.bw stdout
Data were converted from the files provided on the AlphaMissense Downloads website. As with all other tracks, a full log of all commands used for the conversion is available in our -source repository, for hg19 and hg38. The release used for each assembly is shown on the track description page. - +source +repository, for hg19 +and hg38. +The release used for each assembly is shown on the track description page.
Thanks to
Cheng J, Novati G, Pan J, Bycroft C, Žemgulytė A, Applebaum T, Pritzel A, Wong LH, Zielinski M, Sargeant T et al. - -Accurate proteome-wide missense variant effect prediction with AlphaMissense. +Accurate proteome-wide missense variant effect prediction with +AlphaMissense. Science. 2023 Sep 22;381(6664):eadg7492. PMID: 37733863