be9c66b2a69ce9479e4830f5a0d36d9a26d67969 mspeir Sun Feb 16 10:50:26 2025 -0800 very minor formatting changes for desc page, refs #32269 diff --git src/hg/makeDb/trackDb/human/alphaMissense.html src/hg/makeDb/trackDb/human/alphaMissense.html index 316cb195b86..315cbaa8b4f 100644 --- src/hg/makeDb/trackDb/human/alphaMissense.html +++ src/hg/makeDb/trackDb/human/alphaMissense.html @@ -71,46 +71,53 @@ <a href="../cgi-bin/hgTables">Table Browser</a> or the <a href="../cgi-bin/hgIntegrator">Data Integrator</a>. </p> <p> For automated download and analysis, the genome annotation is stored at UCSC in <a href="../goldenPath/help/bigWig.html">bigWig</a> format that can be downloaded from <a href="http://hgdownload.soe.ucsc.edu/gbdb/$db/alphaMissense/" target="_blank">our download server</a>. The files for this track are called <tt>a.bw, c.bw, g.bw, t.bw</tt>. Individual regions or the whole genome annotation can be obtained using our tool <tt>bigWigToWig</tt> which can be compiled from the source code or downloaded as a precompiled binary for your system. Instructions for downloading source code and binaries can be found <a href="http://hgdownload.soe.ucsc.edu/downloads.html#utilities_downloads">here</a>. For example, to extract only annotations in a given region, you could use the following command: +</p> + <p> <tt>bigWigToBedGraph -chrom=chr1 -start=100000 -end=100500 http://hgdownload.soe.ucsc.edu/gbdb/$db/alphaMissense/a.bw stdout</tt> </p> <h2>Methods</h2> <p> Data were converted from the files provided on <a href="https://storage.cloud.google.com/dm_alphamissense" target = "_blank">the AlphaMissense Downloads website</a>. As with all other tracks, a full log of all commands used for the conversion is available in our -<a target=_blank href="https://github.com/ucscGenomeBrowser/kent/blob/master/src/hg/makeDb/doc/">source repository</a>, for <a target=_blank href="https://raw.githubusercontent.com/ucscGenomeBrowser/kent/master/src/hg/makeDb/doc/hg19.txt">hg19</a> and <a target=_blank href="https://github.com/ucscGenomeBrowser/kent/blob/master/src/hg/makeDb/doc/hg38/alphaMissense.txt">hg38</a>. The release used for each assembly is shown on the track description page. - +<a target=_blank +href="https://github.com/ucscGenomeBrowser/kent/blob/master/src/hg/makeDb/doc/">source +repository</a>, for <a target=_blank +href="https://raw.githubusercontent.com/ucscGenomeBrowser/kent/master/src/hg/makeDb/doc/hg19.txt">hg19</a> +and <a target=_blank +href="https://github.com/ucscGenomeBrowser/kent/blob/master/src/hg/makeDb/doc/hg38/alphaMissense.txt">hg38</a>. +The release used for each assembly is shown on the track description page. </p> <h2>Credits</h2> <p> Thanks to </p> <h2>References</h2> <p> Cheng J, Novati G, Pan J, Bycroft C, Žemgulytė A, Applebaum T, Pritzel A, Wong LH, Zielinski M, Sargeant T <em>et al</em>. -<a href="https://www.science.org/doi/abs/10.1126/science.adg7492?url_ver=Z39.88-2003&rfr_id=ori: -rid:crossref.org&rfr_dat=cr_pub%20%200pubmed" target="_blank"> -Accurate proteome-wide missense variant effect prediction with AlphaMissense</a>. +<a href="https://www.science.org/doi/abs/10.1126/science.adg7492" +target="_blank">Accurate proteome-wide missense variant effect prediction with +AlphaMissense</a>. <em>Science</em>. 2023 Sep 22;381(6664):eadg7492. PMID: <a href="https://www.ncbi.nlm.nih.gov/pubmed/37733863" target="_blank">37733863</a> </p>