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Smaller software changes are not announced here. A summary of the three-weekly release changes can be found here. For the full list of our daily code changes head to our GitHub page. Lastly, see our credits page for acknowledgments of the data we host.
+ ++We are pleased to announce the addition of AlphaMissense tracks to the hg38 and +hg19 reference genomes. AlphaMissense scores predict the pathogenicity of +missense variants for all possible single amino acid substitutions in the human +proteome. +
+ ++To access these tracks on the Genome Browser, please visit their description +pages below and change the tracks' visibility: +
+ ++To learn more about the AlphaMissense dataset, please see the +publication by Cheng et al. Science. 2023. +
+We are excited to announce the release of the CIViC track for hg19/GRCh37 and hg38/GRCh38. The Clinical Interpretation of Variants in Cancer (CIViC) is an online database of clinically relevant variant interpretations from expert- and crowd-sourced peer-reviewed literature, clinical trials, and some conference abstracts. The details page for a feature will list diseases and therapies that have been associated with a genomic variant. Visiting the CIViC page for a variant will allow browsing the Molecular Profiles associated with that variant, and in turn each Molecular Profile shows the Clinical Evidence and Assertions for various diseases and therapies.