73365345ad5cfd5f165571982487ceee846c9918 mspeir Sat Feb 22 10:08:31 2025 -0800 adding announcement and hiding track by default, refs #32269 diff --git src/hg/htdocs/goldenPath/newsarch.html src/hg/htdocs/goldenPath/newsarch.html index 0eb433811bf..40da810e818 100755 --- src/hg/htdocs/goldenPath/newsarch.html +++ src/hg/htdocs/goldenPath/newsarch.html @@ -51,30 +51,58 @@ </div> <p>You can sign-up to get these announcements via our <a target=_blank href="https://groups.google.com/a/soe.ucsc.edu/g/genome-announce?hl=en">Genome-announce</a> email list. We send around one short announcement email every two weeks.</p> <p>Smaller software changes are not announced here. A summary of the three-weekly release changes can be found <a target=_blank href="https://genecats.gi.ucsc.edu/builds/versions.html">here</a>. For the full list of our daily code changes head to our <a href="https://github.com/ucscGenomeBrowser/kent/commits/master" target=_blank>GitHub page</a>. Lastly, see our <a href="credits.html" target="_blank"> credits page</a> for acknowledgments of the data we host.</p> <!-- ============= 2025 archived news ============= --> <a name="2025"></a> +<a name="022125"></a> +<h2>Feb. 21, 2025 New AlphaMissense scores track for hg38 and hg19</h2> +<p> +We are pleased to announce the addition of AlphaMissense tracks to the hg38 and +hg19 reference genomes. AlphaMissense scores predict the pathogenicity of +missense variants for all possible single amino acid substitutions in the human +proteome. +</p> + +<p> +To access these tracks on the Genome Browser, please visit their description +pages below and change the tracks' visibility: +</p> +<ul> + <li><a target="_blank" + href="/cgi-bin/hgTrackUi?db=hg38&g=alphaMissense&position=default">AlphaMissense + on hg38/GRCh38</a></li> + <li><a target="_blank" + href="/cgi-bin/hgTrackUi?db=hg19&g=alphaMissense&position=default">AlphaMissense + on hg19/GRCh37</a></li> +</ul> +<p> +To learn more about the AlphaMissense dataset, please see the +publication by <a +href="https://www.science.org/doi/full/10.1126/science.adg7492" +target="_blank">Cheng et al. Science. 2023.</a> +</p> + <a name="021425"></a> <h2>Feb. 14, 2025 CIViC track for hg19 and hg38 is now available</h2> <p> We are excited to announce the release of the CIViC track for <a target="_blank" href="/cgi-bin/hgTrackUi?db=hg19&g=civic&position=default">hg19/GRCh37</a> and <a href="/cgi-bin/hgTrackUi?db=hg38&g=civic&position=default" target="_blank">hg38/GRCh38</a>. The <a target="_blank" href="https://civicdb.org/welcome"> Clinical Interpretation of Variants in Cancer</a> (CIViC) is an online database of clinically relevant variant interpretations from expert- and crowd-sourced peer-reviewed literature, clinical trials, and some conference abstracts. The details page for a feature will list diseases and therapies that have been associated with a genomic variant. Visiting the CIViC page for a variant will allow browsing the Molecular Profiles associated with that variant, and in turn each Molecular Profile shows the Clinical Evidence and Assertions for various diseases and therapies. </p>