9e5cc5d894b020d4e51b7b340f4e6441d0256388 braney Sat Apr 12 10:37:58 2025 -0700 fix quickLifted clinvar submissions track diff --git src/hg/hgc/clinvarSubLolly.c src/hg/hgc/clinvarSubLolly.c index a20af50ee39..d0f3fd3f2b6 100644 --- src/hg/hgc/clinvarSubLolly.c +++ src/hg/hgc/clinvarSubLolly.c @@ -1,137 +1,139 @@ #include "common.h" #include "wiggle.h" #include "cart.h" #include "hgc.h" #include "hCommon.h" #include "hgColors.h" #include "bigBed.h" #include "hui.h" #include "subText.h" #include "trackHub.h" #include "clinvarSubLolly.h" #include "chromAlias.h" #include "quickLift.h" char *statusByScore[] = { "Other", "Benign", "Likely Benign", "Uncertain significance", "Likely pathogenic", "Pathogenic", }; void printSubmissions(struct trackDb *tdb, char *chrom, int start, int end, unsigned wantScore, int numSubs, boolean not) /* Print out all the submissions at this position that match the * desired score (ie. clinical status). * If "not" is true, then print out all submissions that do NOT match score. * We're grabbing these records out of a second bigBed that's referenced by * "xrefDataUrl" in the trackDb. */ { char *xrefDataUrl = hReplaceGbdb(trackDbSetting(tdb, "xrefDataUrl")); struct bbiFile *bbi = bigBedFileOpenAlias(xrefDataUrl, chromAliasFindAliases); struct asObject *as = bigBedAsOrDefault(bbi); struct lm *lm = lmInit(0); struct bigBedInterval *bbList = bigBedIntervalQuery(bbi, chrom, start, end, 0, lm); int count; if (not) count = slCount(bbList) - numSubs; else count = numSubs; // nothing to print if (count == 0) return; if (!not) printf("<BR><B>There are %d submissions at this position with clinical significance '%s'.</B><BR>\n", count, statusByScore[wantScore]); else printf("<BR><B>There are %d submissions at this position with some other clinical significance.</B><BR>\n", count); // Step through intervals at the position to find ones that match the score we're looking for struct bigBedInterval *bb; for (bb = bbList; bb != NULL; bb = bb->next) { char *fields[bbi->fieldCount]; int restCount = chopTabs(cloneString(bb->rest), fields); int score = atoi(fields[1]); if (not ^ (score != wantScore)) continue; int restBedFields = 6; char **extraFields = (fields + restBedFields); int extraFieldCount = restCount - restBedFields; extraFieldsPrintAs(tdb, NULL, extraFields, extraFieldCount, as); } printf("<BR>"); } void doClinvarSubLolly(struct trackDb *tdb, char *item) /* Put up page for clinvarSubLolly track. */ { genericHeader(tdb, NULL); struct sqlConnection *conn = NULL; if (!trackHubDatabase(database)) conn = hAllocConnTrack(database, tdb); int start = cartInt(cart, "o"); int end = cartInt(cart, "t"); char *chrom = cartString(cart, "c"); char *fileName = bbiNameFromSettingOrTable(tdb, conn, tdb->table); struct bbiFile *bbi = bigBedFileOpenAlias(hReplaceGbdb(fileName), chromAliasFindAliases); struct lm *lm = lmInit(0); struct bigBedInterval *bb, *bbList; char *quickLiftFile = cloneString(trackDbSetting(tdb, "quickLiftUrl")); struct hash *chainHash = NULL; if (quickLiftFile) bbList = quickLiftGetIntervals(quickLiftFile, bbi, chrom, start, end, &chainHash); else bbList = bigBedIntervalQuery(bbi, chrom, start, end, 0, lm); char *fields[bbi->fieldCount]; for (bb = bbList; bb != NULL; bb = bb->next) { struct bed *bed = NULL;; char startBuf[16], endBuf[16]; struct bed tempBed; bigBedIntervalToRow(bb, chrom, startBuf, endBuf, fields, bbi->fieldCount); if (quickLiftFile) bed = quickLiftIntervalsToBed(bbi, chainHash, bb); else { tempBed.chrom = chrom; tempBed.chromStart = bb->start; tempBed.chromEnd = bb->end; tempBed.name = fields[3]; bed = &tempBed; } if (!(bed->chromStart == start && bed->chromEnd == end)) continue; // our names are unique char *name = bed->name; boolean match = (isEmpty(name) && isEmpty(item)) || sameOk(name, item); if (!match) continue; int numSubs = chopString(fields[12], ",", NULL, 0); printPos(bed->chrom, bed->chromStart, bed->chromEnd, NULL, FALSE, name); + char chromBuf[2048]; + bbiCachedChromLookup(bbi, bb->chromId, 0, chromBuf, sizeof chromBuf); // print all the submissions that match the clinical significance of the // bead that the user clicked on. - printSubmissions(tdb, chrom, bb->start, bb->end, atoi(fields[4]), numSubs, FALSE); + printSubmissions(tdb, chromBuf, bb->start, bb->end, atoi(fields[4]), numSubs, FALSE); // now print the ones with a different clinical status - printSubmissions(tdb, chrom, bb->start, bb->end, atoi(fields[4]), numSubs, TRUE); + printSubmissions(tdb, chromBuf, bb->start, bb->end, atoi(fields[4]), numSubs, TRUE); // we found what we wanted break; } printTrackHtml(tdb); }