859df2c7c8948da00a2305e90fafe00016032ca7
gperez2
  Thu May 8 12:41:02 2025 -0700
code review edits, refs #35693

diff --git src/hg/makeDb/trackDb/human/vistaEnhancersBb.html src/hg/makeDb/trackDb/human/vistaEnhancersBb.html
index ca90a00db56..d85ecced2aa 100644
--- src/hg/makeDb/trackDb/human/vistaEnhancersBb.html
+++ src/hg/makeDb/trackDb/human/vistaEnhancersBb.html
@@ -1,91 +1,91 @@
 <H2>Description</H2>
 
 <p>This track shows potential enhancers whose activity was experimentally validated in transgenic
 mice. Most of these noncoding elements were selected for testing based on their extreme conservation
 in other vertebrates or epigenomic evidence (ChIP-Seq) of putative enhancer marks. More information
 can be found on the <a href="https://enhancer.lbl.gov/" target="_blank">VISTA Enhancer Browser</a>
 page.
 </p>
 
 <h2> Display Conventions and Configuration </h2>
 <p>Items appearing in <b><font color="#2260f2">blue</font></b> (positive) indicate that a
 reproducible pattern was observed in the in vivo enhancer assay under at least one of the
 tested conditions. Items appearing in <b><font color="#646464">gray</font></b> (negative) indicate
 that NO reproducible pattern was observed in the in vivo enhancer assay under any of the tested
 conditions. This does not exclude the possibility that this region is a reproducible enhancer active
 under different conditions, for example at an earlier or later timepoint in development.</p>
 
 <h2>Methods</h2>
 <p> Excerpted from the Vista Enhancer <a HREF="https://enhancer.lbl.gov/vista/manual"
-TARGET=_BLANK>Mouse Enhancer Screen Handbook and Methods</a> page at the Lawrence Berkeley
+target="_blank">Mouse Enhancer Screen Handbook and Methods</a> page at the Lawrence Berkeley
 National Laboratory (LBNL) website:
 <h4>Enhancer Candidate Identification</h4>
 <p> Most enhancer candidate sequences are identified by extreme evolutionary sequence conservation or
 by ChIP-seq.  Detailed information related to enhancer identification by extreme evolutionary
 conservation can be found in the following publications:
 </p>
 <ul>
 <li>Pennacchio et al., <a href="https://pubmed.ncbi.nlm.nih.gov/11253049/" target="_blank"
 >Genomic strategies to identify mammalian regulatory sequences.</a> Nature Rev Genet 2001</li>
 <li>Nobrega et al., <a href="https://pubmed.ncbi.nlm.nih.gov/14563999/" target="_blank"
 >Nobrega et al., Scanning human gene deserts for long-range enhancers.</a> Science 2003</li>
 <li>Pennacchio et al., <a href="https://pubmed.ncbi.nlm.nih.gov/17086198/" target="_blank"
 >In vivo enhancer analysis of human conserved non-coding sequences.</a> Nature 2006</li>
 <li>Visel et al., <a href="https://pubmed.ncbi.nlm.nih.gov/17276707/" target="_blank"
 >Enhancer identification through comparative genomics.</a> Semin Cell Dev Biol. 2007</li>
 <li>Visel et al., <a href="https://pubmed.ncbi.nlm.nih.gov/18176564/" target="_blank"
 >Ultraconservation identifies a small subset of extremely constrained developmental enhancers.</a>
  Nature Genet 2008</li>
 </ul>
 
 <p>Detailed information related to enhancer identification by ChIP-seq can be found in the
 following publications:</p>
 <ul>
 <li>Visel et al., <a href="https://pubmed.ncbi.nlm.nih.gov/19212405/" target="_blank"
 >ChIP-seq accurately predicts tissue-specific activity of enhancers.</a> Nature 2009</li>
 <li>Visel et al., <a href="https://pubmed.ncbi.nlm.nih.gov/19741700/" target="_blank"
 >Genomic views of distant-acting enhancers.</a> Nature 2009</li>
 </ul></p>
 
 <p>See the Transgenic Mouse Assay section for experimental procedures that were used to perform the
 transgenic assays: <a HREF="https://enhancer.lbl.gov/vista/manual"
-TARGET=_BLANK>Mouse Enhancer Screen Handbook and Methods</a> 
+target="_blank">Mouse Enhancer Screen Handbook and Methods</a>
 
 <p>UCSC converted the
 <a href="https://gitlab.com/egsb-mfgl/vista-data/" target="_blank">vista-data</a> bed files for
 hg38 and mm10 into bigBed format using the bedToBigBed utility. The data for mm39 was lifted over
 from mm10. The data for hg19 was lifted over from hg38.</p> 
 
 <h2>Data Access</h2>
 <p>
 VISTA Enhancers data can be explored interactively with the
 <a href="../cgi-bin/hgTables">Table Browser</a> and cross-referenced with the
 <a href="../cgi-bin/hgIntegrator">Data Integrator</a>. For programmatic access, the track can be
 accessed using the Genome Browser's <a href="/goldenPath/help/api.html">REST API</a>. ReMap
 annotations can be downloaded from the Genome Browser's
 <a href="https://hgdownload.soe.ucsc.edu/gbdb/$db/vistaEnhancers">download server</a>
 as a bigBed file. This compressed binary format can be remotely queried through
 command line utilities. Please note that some of the download files can be quite large.</p>
 
 <h2>Credits</h2>
 <p>Thanks to the Lawrence Berkeley National Laboratory for providing this data.</p>
 
 
 <h2>References</h2>
 <p>
 Kosicki M, Baltoumas FA, Kelman G, Boverhof J, Ong Y, Cook LE, Dickel DE, Pavlopoulos GA, Pennacchio
 LA, Visel A.
 <a href="https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/gkae940" target="_blank">
 VISTA Enhancer browser: an updated database of tissue-specific developmental enhancers</a>.
 <em>Nucleic Acids Res</em>. 2025 Jan 6;53(D1):D324-D330.
 PMID: <a href="https://www.ncbi.nlm.nih.gov/pubmed/39470740" target="_blank">39470740</a>; PMC: <a
 href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11701537/" target="_blank">PMC11701537</a>
 </p>
 <p>
 Visel A, Minovitsky S, Dubchak I, Pennacchio LA.
 <a href="https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/gkl822" target="_blank">
 VISTA Enhancer Browser--a database of tissue-specific human enhancers</a>.
 <em>Nucleic Acids Res</em>. 2007 Jan;35(Database issue):D88-92.
 PMID: <a href="https://www.ncbi.nlm.nih.gov/pubmed/17130149" target="_blank">17130149</a>; PMC: <a
 href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1716724/" target="_blank">PMC1716724</a>
 </p>