+ + Genome Browser screenshot of BRCA1 exon 19 showing the alignment and heatmap tracks. +
+You can sign-up to get these announcements via our Genome-announce email list. We send around one short announcement email every two weeks.
Smaller software changes are not announced here. A summary of the three-weekly release changes can be found here. For the full list of our daily code changes head to our GitHub page. Lastly, see our credits page for acknowledgments of the data we host.
+ ++We are excited to announce the release of the MaveDB Experiment Heatmaps and +Alignment track for hg38. This release provides heatmaps of multiplexed assays of +variant effects (MAVE) from MaveDB. +Each heatmap presents the results of an experiment where many small substitutions were tested within +a gene to examine their functional consequences. Accompanying tracks display alignments of each +experiment sequence to the genome. +
++Please note that only a subset of MaveDB experiments could be displayed as heatmaps; the sequence +alignments in this track only cover those experiments.
+ + ++Hover-over each item in the heatmap to see the consequence of substituting invididual amino acids +within the genome with alternatives. Score ranges vary among experiments, but each is presented +with the highest scores in red, the lowest +scores in blue, and scores at the midpoint +between the two in silver. Higher scores +correspond to a higher enrichment level for that variant compared to others in the experiment set. +
++We would like to thank MaveDB for making this data publicly available. We would also like to thank +Jonathan Casper and Jairo Navarro for the creation and release of the Genome Browser tracks.
+New Capture long-seq (CLS) long-read lncRNAs tracks are available for hg38 and mm10. These tracks represent the results of targeted long-read RNA sequencing aimed at identifying lowly expressed lncRNAs. The data is comprised of the capture target regions, the reads, and transcript models organized in the following way: