ad92b87bb799c20abccadf1f923972c1a9b6a6e7
max
  Fri Oct 17 06:39:16 2025 -0700
adding gnomad mpc track, ref #36531

diff --git src/hg/makeDb/doc/hg19.txt src/hg/makeDb/doc/hg19.txt
index f1bfe9b38f0..05fd850a879 100644
--- src/hg/makeDb/doc/hg19.txt
+++ src/hg/makeDb/doc/hg19.txt
@@ -35926,15 +35926,22 @@
 #  - a few protein-coding genes not in the assembly
 #  - pseudogenes and non-coding genes not in GENCODE or RefSeq for unknown reasons
 #  - locus_group `other' types that are not mapped.
 
 # put the files into /gbdb
 mkdir -p /gbdb/hg19/hgnc
 ln -sf $(realpath hgnc.bb search.ix search.ixx) /gbdb/hg19/hgnc/
 
 # double check
 ls -l /gbdb/hg19/hgnc/
 file  /gbdb/hg19/hgnc/*
 
 # if not already done for hg38:
 # edit trackDb/human/trackDb.ra to set filterValues.locus_type
 # from the locus_type.filter.txt file
+
+#############################################################################
+# gnomad MPC 2025-10-17 max
+cd /hive/data/genomes/hg19/bed/gnomad/mpc
+wget https://storage.googleapis.com/gcp-public-data--gnomad/release/2.1.1/regional_missense_constraint/gnomAD_v2.1.1_transcripts_with_rmc.tsv
+cat gnomAD_v2.1.1_transcripts_with_rmc.tsv | python ~/kent/src/hg/makeDb/gnomad/gnomadMpcToBed.py | sort -k1,2n > mpc.bed
+bedToBigBed mpc.bed ../../../chrom.sizes mpc.bb -as=~/kent/src/hg/makeDb/gnomad/mpc.as -type=bed9+ -tab