+JASPAR 2026 features a deep learning (DL) collection, providing a paradigm shift in modeling +and characterizing TF-DNA interactions with 1259 BPNet models trained on Homo sapiens ENCODE +chromatin immunoprecipitation followed by sequencing (ChIP-seq) datasets from 240 TFs and +interpreted to reveal predictive motif patterns for the models. The motifs associated with +the same TF were clustered to provide a summary of the binding properties, resulting in +240 primary and 113 alternative motif patterns in the DL collection. See the JASPAR 2026 publication +for more information.
+The JASPAR 2024 update expanded the JASPAR CORE collection by 20% (329 added and 72 upgraded profiles). The new profiles were introduced after manual curation, in which 26 629 TF binding motifs were curated and obtained as PFMs or discovered from ChIP-seq/-exo or DAP-seq data. 2500 profiles from JASPAR 2022 were revised to either promote them to the CORE collection, update the associated metadata, or remove them because of validation inconsistencies or poor quality. The JASPAR database stores and focuses mostly on PFMs as the model of choice for TF-DNA interactions. More information on the methods can be found in the JASPAR 2024 publication or on the JASPAR website.
JASPAR 2022 contains updated transcription factor binding sites with additional transcription factor profiles. More information on the methods can be found in the @@ -176,31 +185,32 @@ Additional resources are available directly from the JASPAR group:
The JASPAR group provides TFBS predictions for many additional species and -genomes, accessible by connection to their +genomes. The 20206 release is available as a native track on the following genomes, and additionally +on mm10 and araTha1 by connection to their Public Hub or by clicking the assembly links below:
| Species | Genome assembly versions |
| Human - Homo sapiens | hg19, hg38 |
| Mouse - Mus musculus | @@ -298,15 +308,26 @@ PMID: 29140473; PMC: PMC5753243