383da828477aad2b3c6053880a64fdbfc2a00cd9 max Thu Mar 19 02:30:41 2026 -0700 Fix varFreqs HTML issues and trexplorer citation, from AI code review 2026-03-19, refs #36642 Fix broken $db download URLs to hg38 in 14 HTML files, correct "Japanese" to "Korean" in kova.html, fix "area" typo in schema.html, fix "Finnland" to "Finland" in varFreqs.ra, normalize GREGoR capitalization, fix grammar, quote all target=_blank attributes, capitalize GitHub consistently, and fix bioRxiv citation formatting in trexplorer.html. Co-Authored-By: Claude Opus 4.6 diff --git src/hg/makeDb/trackDb/human/hrc.html src/hg/makeDb/trackDb/human/hrc.html index 1d42232fd08..6a9ac4a0a50 100644 --- src/hg/makeDb/trackDb/human/hrc.html +++ src/hg/makeDb/trackDb/human/hrc.html @@ -9,51 +9,51 @@

The contributing studies include the 1000 Genomes Project, UK10K, and many other cohorts. Since 1000 Genomes data is already available as a separate track, this track shows only the frequencies from the non-1000 Genomes samples (~30,000 individuals), resulting in 38.3 million variants after lifting from GRCh37 to GRCh38.

Data Access

The data can be explored interactively with the Table Browser or the Data Integrator. For programmatic access, our REST API can be used; the track name is hrc. For bulk download, the VCF file can be obtained from -our download server. +our download server.

The original site list file can also be downloaded from the HRC website. -Our Github repo contains a +Our GitHub repo contains a script that converts the tab-separated file to VCF and lifts it to hg38.

Methods

The HRC r1.1 site list was downloaded from the HRC website as a tab-separated file on GRCh37, converted to VCF and lifted to GRCh38 with UCSC liftOver. Only frequencies from the non-1000 Genomes samples (~30,000 of the 32,488 total) are included, since 1000 Genomes data is available separately. Of 40.4M input variants, 8,052 were unmapped by liftOver and 2.1M were present only in 1000 Genomes samples and were dropped, leaving 38.3M variants. -We provide documentation that indicates how all source files of the varFreqs track were converted in the makeDoc file of the track. -For some tracks, python scripts were necessary and are also available from Github. +We provide documentation that indicates how all source files of the varFreqs track were converted in the makeDoc file of the track. +For some tracks, python scripts were necessary and are also available from GitHub.

Credits

Thanks to the Haplotype Reference Consortium and all contributing studies for making this reference panel publicly available.

References

McCarthy S, Das S, Kretzschmar W, Delaneau O, Wood AR, Teumer A, Kang HM, Fuchsberger C, Danecek P, Sharp K et al. A reference panel of 64,976 haplotypes for genotype imputation. Nat Genet. 2016 Oct;48(10):1279-83.