8c1ebdae695b1bb40e45f41aff4a4f9fb9e52491
max
  Thu May 28 05:43:13 2026 -0700
[Claude] add EVE missense variant effect heatmap track for hg38

#Preview2 week - bugs introduced now will need a build patch to fix
Heatmap bigBed track showing EVE scores for all possible missense
substitutions in 2,949 disease-associated proteins. One entry per
protein; columns = amino acid positions at genomic codon coordinates,
rows = 20 standard amino acids. Colors blue (benign) to red (pathogenic).
Includes conversion script, autoSql, trackDb, HTML doc, and makedoc.
Added to predictionScoresSuper. refs #31804

Co-Authored-By: Claude Sonnet 4.6 <noreply@anthropic.com>

diff --git src/hg/makeDb/trackDb/human/eve.ra src/hg/makeDb/trackDb/human/eve.ra
new file mode 100644
index 00000000000..3a55f992aea
--- /dev/null
+++ src/hg/makeDb/trackDb/human/eve.ra
@@ -0,0 +1,12 @@
+track eve
+shortLabel EVE Scores
+longLabel EVE Missense Variant Effect Scores
+type bigBed 12 +
+parent predictionScoresSuper
+bigDataUrl /gbdb/$D/eve/eve.bb
+style heatmap
+visibility pack
+maxWindowCoverage 200000
+filterText.name .*
+filterType.name regexp
+filterLabel.name Protein name