75640104127592366faa7478485e5a88f8144a0b
mspeir
  Thu May 14 08:44:10 2026 -0700
fixing Miklem -> Micklem, refs #37539

diff --git src/hg/makeDb/trackDb/cpgIsland.html src/hg/makeDb/trackDb/cpgIsland.html
index f044adab571..c2f6d0d2856 100644
--- src/hg/makeDb/trackDb/cpgIsland.html
+++ src/hg/makeDb/trackDb/cpgIsland.html
@@ -1,41 +1,41 @@
 <H2>Description</H2>
 <P>
 CpG islands are associated with genes, particularly housekeeping
 genes, in vertebrates.  CpG islands are typically common near
 transcription start sites, and may be associated with promoter
 regions.  Normally a C (cytosine) base followed immediately by a 
 G (guanine) base (a CpG) is rare in
 vertebrate DNA because the Cs in such an arrangement tend to be
 methylated.  This methylation helps distinguish the newly synthesized
 DNA strand from the parent strand, which aids in the final stages of
 DNA proofreading after duplication.  However, over evolutionary time
 methylated Cs tend to turn into Ts because of spontaneous
 deamination.  The result is that CpGs are relatively rare unless
 there is selective pressure to keep them or a region is not methylated
 for some reason, perhaps having to do with the regulation of gene
 expression.  CpG islands are regions where CpGs are present at
 significantly higher levels than is typical for the genome as a whole.
 </P>
 
 <H2>Methods</H2>
 <P>
 CpG islands are predicted by searching the sequence one base at a
 time, scoring each dinucleotide (+17 for CG and -1 for others) and
 identifying maximally scoring segments.  Each segment is then
 evaluated for the following criteria:
 <UL>
 <LI>GC content roughly 50% or greater 
 <LI>length greater than 200
 <LI>ratio greater than 0.6 of observed number of CG dinucleotides to the 
 expected number on the basis of the GC content of the segment 
 </UL> </P>
 <P>
 The CpG count is the number of CG dinucleotides in the island.  
 The Percentage CpG is the ratio of CpG nucleotide bases
 (twice the CpG count) to the length.  </P>
 
 <H2>Credits</H2>
 <P>
 This track was generated using a modification of a program developed by 
-G. Miklem and L. Hillier. </P>
+G. Micklem and L. Hillier. </P>