f09028646c6429d692a80cc38d214e805724e7fa lrnassar Sat Jun 13 10:51:38 2026 -0700 lrSv: default all subtracks to hide except lrSvAll (pack), add lrSvAll desc page. refs #36258 Set the 15 released lrSv subtracks to "visibility hide" so the supertrack opens with only the merged overview visible; lrSvAll stays "visibility pack". Add the missing lrSvAll.html description page (Description, Display Conventions, Methods, Data Access, Credits) describing the position-merged combined track. diff --git src/hg/makeDb/trackDb/human/lrSvAll.html src/hg/makeDb/trackDb/human/lrSvAll.html new file mode 100644 index 00000000000..29ef4d56918 --- /dev/null +++ src/hg/makeDb/trackDb/human/lrSvAll.html @@ -0,0 +1,81 @@ +<h2>Description</h2> +<p> +This track combines the structural-variant (SV) callsets from the individual +subtracks of the <a href="hgTrackUi?g=lrSv">Long-read SVs</a> supertrack into a +single, position-merged overview. Each item is an SV locus seen in one or more +of the contributing long-read databases. For every merged locus the track +records which databases report it, the summed allele count across those +databases, and the range of allele frequencies observed, making it useful for +quickly seeing how widely an SV has been reported across cohorts. +</p> +<p> +This is a summary view. For cohort-specific genotypes, per-population allele +frequencies, and dataset-specific annotations, use the individual subtracks of +the supertrack. The merge includes the released long-read callsets only; +preliminary or unpublished subtracks (e.g. the Kim PD brain, 1000 Genomes +linear, and HPRC Jasmine sets) are <b>not</b> part of this merged track. +</p> + +<h2>Display Conventions and Configuration</h2> +<p> +Items are colored by SV type, matching the individual subtracks: +<ul> +<li><span style="color: rgb(200,0,0);">Deletions (DEL)</span> - red</li> +<li><span style="color: rgb(0,0,200);">Insertions (INS)</span> - blue</li> +<li><span style="color: rgb(0,160,0);">Duplications (DUP)</span> - green</li> +<li><span style="color: rgb(230,140,0);">Inversions (INV)</span> - orange</li> +<li><span style="color: rgb(140,0,200);">Complex and other multi-allele events</span> - purple</li> +</ul> +</p> +<p> +The mouseover shows the variant name, SV type, reference and insertion lengths, +the list of contributing source databases, the allele-frequency range across +those databases, and the total allele count. Filters are available for the +<b>source database</b>, <b>SV type</b>, <b>SV length</b>, <b>insertion +length</b>, <b>total allele count</b>, <b>minimum and maximum allele +frequency</b>, and the <b>number of source databases</b> reporting each locus. +The detail page lists the per-database allele counts. +</p> + +<h2>Methods</h2> +<p> +The merged track is built by the <tt>lrSvMergeAll.py</tt> script, which reads +the bigBed of each contributing subtrack (configured in +<tt>databases.tsv</tt>) and groups records that share an identical +<tt>(chromosome, start, end)</tt> position and SV type. For each merged locus +the script records the set of contributing databases (<tt>sources</tt>), the +number of those databases (<tt>sourceCount</tt>), the sum of their allele counts +(<tt>AC</tt>), and the minimum and maximum allele frequency across databases +that report one (<tt>minAF</tt>, <tt>maxAF</tt>). The per-database allele counts +are carried as additional columns. +</p> +<p> +The step-by-step build commands are recorded in the UCSC makeDoc for this track +collection: +<a href="https://github.com/ucscGenomeBrowser/kent/blob/master/src/hg/makeDb/doc/hg38/lrSv.txt" target="_blank"> +doc/hg38/lrSv.txt</a>. The merge script and autoSql schema live in +<a href="https://github.com/ucscGenomeBrowser/kent/tree/master/src/hg/makeDb/scripts/lrSv" target="_blank"> +makeDb/scripts/lrSv</a>. +</p> + +<h2>Data Access</h2> +<p> +The data can be explored interactively with the +<a href="../cgi-bin/hgTables">Table Browser</a> or the +<a href="../cgi-bin/hgIntegrator">Data Integrator</a>, and accessed +programmatically through our <a href="https://api.genome.ucsc.edu">API</a>, +track=<i>lrSvAll</i>. +</p> +<p> +The bigBed is available from +<a href="http://hgdownload.soe.ucsc.edu/gbdb/$db/lrSv/" target="_blank">our +download server</a> as <tt>lrSvAll.bb</tt>. Example: +<tt>bigBedToBed http://hgdownload.soe.ucsc.edu/gbdb/$db/lrSv/lrSvAll.bb -chrom=chr21 -start=0 -end=100000000 stdout</tt>. +</p> + +<h2>Credits</h2> +<p> +This merged view is derived entirely from the contributing long-read SV +callsets; please see the individual subtrack description pages for the data +producers and citations for each cohort. +</p>